Drugs Acting On RAAS

Question 1

RAAS Concept

Answer 1

Angiotensinogen –> Angiotensin I –> Angiotensin II –> AT1 Receptor

Question 2

Functions of Angiotensin II

Answer 2

Rapid Pressor:
   direct vasoconstriction
   increased peripheral NE
Slow Pressor:
   Increased Na reabsorption
   Release of Aldosterone from kidneys
Vascular and Cardiac Hypertrophy and       Remodeling

Question 3

ACE Inhibitor: Indications

Answer 3

Hypertension
Cardiac Failure (decrease systemic constriction)
MI
Chronic Renal Failure (decrease remodeling)
Diabetic Neuropathy (inhibit remodeling)

Question 4

ACE Inhibitor: Side Effects

Answer 4

Hypotension
Cough (nonproductive, due to bradykinin, substance P accumulation)
Hyperkalemia (in combo with K supplement, sparing diuretics, renal insufficiency)
Acute Renal Failure
Fetopathic Potential
Maculopapular rash
Angioneurotic Oedema (Bradykinin)

Question 5

ACE Inhibitor: Drug Interactions

Answer 5

Antacids: decrease bioavailability due to increase pH

K+ sparing diuretics: exacerbation of hyperkalemia

Question 6

ACE Inhibitor: Drug List

Answer 6

Captopril
Enalapril
Ramipril
Lisinopril
Fosinopril

Question 7

Non Peptide AT1 Receptor Antagonist

Mechanism of Action and Why Use
Effects

Answer 7

Use: no cough and angioedema
Can’t be orally administered

Competitive Inhibitor

Same Effects as ACE Inhibitor + uricosuric effects

Question 8

Non Peptide AT1 Receptor Antagonist

Side Effects

Answer 8

Hypotension
Hyperkalemia
Fetopathic Potential

Question 9

Non Peptide AT1 Receptor Antagonist

Drug List

Answer 9

Losartan
Valsartan
Irbesartan
Candesartan

Question 10

Renin Inhibitor

Mechanism

Answer 10

Inhibit conversion of angiotensinogen to Angiotensin I

Orally active

Question 11

Renin Inhibitor Side Effects

Answer 11

Hypotension

Hyperkalemia

Question 12

Renin Inhibitor

Drug List

Answer 12

Aliskiren