Drugs Flashcards
Aripiprazole
Atypical antipsychotic
Ranitidine
H2 R blocker
Name three first generation APs
Haloperidol
Flupentixol
Prochlorperazine
What is acute dystonic reaction.
Involuntary muscle spasms , can lead to airway obstruction
Most common with haloperidol
What side effects are most common with typical antipsychotics
Extrapyramidal side effects inc
- Parkinsonian symptoms
- tardive dyskinesia
- dystonia and dyskinesia
- akathesia (restlessness)
What is tardive dyskinesia
A common SE with 1st gen APs
Rhythmic involuntary facial movement involving face , tongue and jaw.
Potentially irreversible
Name 5 second generation APs
Olanzapine Quitiapine Clozapine Risoeridone Aripiprazole
Why do APs cause hyperprolactineamia
As dopamine inhibits prolactin . APs are D2R antagonists so there is less dopamine release therefore less inhibition of prolactin
What are the endocrine SEs of APs
Hyperprolactinemia
Hyperglycaemia
Sexual dysfunction
What are the symptoms of hyperprolactinemia
Galatorrhoea
Sexual dysfunction
Reduced bone density
Breast enlargement
What type of drug is gentamyacin
Aminoglycoside
What is a contraindication to using gentamyacin
Myasthenia Gravis
When are peak gent levels taken
1hr post dose
What would you do if peak gent levels were too high
Decrease dose
What would you do if trough gent levels were too high
Decrease frequency
What is the first drug you give in NSTEMI, what are the treatment options after this ?
Asprin
1) Angiography +PCI within 120mins
2) fibrinolysis
3) medical management with clopidogrel +cardiac rehab
Name a fibrinolytic drug
Alteplase
Desmoplase
Side effects of gent
Ototoxicity
Nephrotoxisity
What channel do loop diuretics act on - what action do they have
NKCC2
Inhibit absorption of na & cl
What thiazide diuretic would you give in 70+s
Indipamide
What is the loading dose of asprin given in NSTEMI
300mg
Name three types of anti clotting drug , their indication and an example
Anti platelet - to prevent arterial clots - asprin /clopidogrel
Anticoagulant - heparin / warfarin -DVT
Thrombolytic - fibrinolysis - alteplase / desmoplase
Name a rate limiting CCB
Verapamil
Diltiazem
Ivabradine
HCN channel blocker used in angina if BB+CCB cannot be tolerated
