Drugs Flashcards

1
Q

PPI

A

Contraindicated with atazanavir and rilpiverine as both require low gastric pH

Antacids and H2 blockers ok but take at different time - less long lasting effect

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2
Q

Antacids

A

Need to be timed away from integrases due to chelation of II

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3
Q

Dabigatran

A

Coadministration with ritonivir and cobicistat increases dabigatran exposure and therefore increases bleeding risk
can give with ritonivir with close monitoring
Cannot give with cobicistat

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4
Q

Metformim

A

Increased exposure with DTG
Risk is lactic acidosis
Close monitor and consider adjusting dose with DTG. Close monitoring with BIC only if renal impairment.

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5
Q

IM carbotegravir/rilpivirine

A

Exposure reduced by strong enzyme inducers eg rifampicin

Avoids other DDI eg. Antacids

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6
Q

Corticosteroids

A

Avoid with boosters
Risk of Cushing syndrome increased even if not taking steroid orally

Beclometasone safest

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7
Q

Clopidogrel

A

Not with boosters - 44% HIV patients not achieving platelet inhibition

Prasugel is ok

If must have clopidogrel change ARVs

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8
Q

Injectable?

A
Carbotegravir with rilpivirine
Aqueous particle suspension
Monthly use
Cabenuva
ATLAS and FLAIR trial
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9
Q

Micro needle patch

A

7 days exposure achieved from 1 patch with rilpivirine

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10
Q

Apixaban

A

Induced by ETR

EDOXABAN SAFER

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11
Q

DOACs

A

Not with PIs - increase exposure
Not with NNRTI - decrease exposure (Doravirine safe)

INSTI safe

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