Drugs Flashcards
Phalloidin
Death cap mushroom toxin bonds Actin filament and stabilizes it to prevent depolymerization
Cytochalasin
Fungal toxin that binds to AF and blocks polymerization
Latruncilin
Toxin in sponges that binds actin monomers to prevent polymerization
Mitotic inhibitors
Target microtubules and inhibit growth orrrr shrinkage of MT by freezing cells in mitosis so that they die eventually
Includes taxanes and vinca alkaloids
Taxanes
Mitotic inhibitors
Stabilize MT by preventing MT from shrinking
Ex- paclitaxel
Paclitaxel
Mitotic inhibitors
Stabilize MT by preventing MT from shrinking
A taxane
Vinca alkaloids
MT depolymerizers
Inhibit assembly of MT
Ex: vinblastine and vincristine
Vinblastine
Vinca alkaloids
Vincristine
Vinca alkaloid
Sulfonyl urea class of drugs
Inhibits ATP sensitive K+ channels that causes depolarization and increase in insulin release from beta cells
Rifampin
Inhibits transcription initiation in prokaryotes
Binds beta*** subunit of rna pol
Changes confirmation of RNA pol and RNA synthesis can not be initiated
Used to treat tuberculosis, leprosy, legionnaires disease
No effect on hosts cells since it doesn’t bind to eukaryotic rna pol
Fidaxomicin
Blocks initial separation of DNA strands by rna pol
Acts on sigma subunit if rna approved for treatment of c diff infection
Chloramphenicol
Bind 50S portion of ribosome and inhibits formation of peptide bond
Erythromycin
Binds 50s subunit, prevents translocation - movement of ribosome along mRNA
Tetracycline
Interfere with attachment of tRNA to mRNA ribosome complex
