Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Sedation > Drugs > Flashcards

Drugs Flashcards

1
Q

GABAa receptor MOA

A

chloride flux into cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

drugs that augment GABAergic neurotransmission

A

propofol and barbs and benzo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

binding sit of benzo receptor (what receptor do benzos enhance)

A

GABAa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

competitive antagonist of BNZ receptor

A

flumazenil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

agonists of GPCR system reduce activity of what?

A

adenyl cyclase –> cause dephosphorylation of ion channels –> activates K channels and hyperpolarization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

opioids and central alpha-2 receptors are examples of what receptor class?

A

GPCR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

central alpha 2 receptor agonists (2)

A

clonidine and dexmedetomidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

opioid (mew1/2) receptor agonists

A

fentanyl, morphine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Ketamine blocks what receptor?

A

NMDA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

midazolam dosing

A

0.05-0.1mg/kg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

midazolam onset

A

<60sec

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

midazolam repeat dose

A

0.05-0.1mg/kg

q3-5min

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

midazolam duration

A

15-30min

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

AE midazolam

A

antegrade amnesia, disinhibition, DIZZINESS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

central alpha-2 agonists affect what channels?

A

potassium channels - K efflux out of cell and membrane hyperpolarization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

CI to dexmedetomidine use

A

BP instability, bradycardia, (i.e. volume depleted)

SA/AV node block, digoxin therapy

17
Q

Dexmedetomidine dosing bolus

A

0.5-2 (1-3) mcg/kg over 5-10min

18
Q

demedetomidine infusion dose?

max infusion rate?

A

1-2mcg/kg/hr (max 100mcg/hr)

19
Q

propofol does NOT have what property (i.e. anxiolytic, amnestic, hypnotic, anesthetic)

A

analgesic

20
Q

AE of propofol

A

respiratory depression (dose dependent decrease in ventilatory response to CO2 –> decrease VT decrease)

21
Q

propofol dosing and interval frequency

A

1-2mg/kg q1min (repeat dose 0.5-1mg/kg)

22
Q

propofol duration

A

5-10min

23
Q

fentanyl peak effect

A

4-5min

24
Q

fentanyl dose

A

1-2mcg/kg infused slowly

25
Q

AE of fentanyl if pushed fast

A

chest wall rigidity

26
Q

fentanyl duration

A

30 min

27
Q

Ketamine properties at lowest doses v. highest doses (i.e. anxiolytic, amnestic, hypnotic, anesthetic)

A

lowest doses - anxiolysis and analgesia
mid doses - antegrade amnesia
highest - dissociative sedation

28
Q

ketamine physiologic effects

A

increased HR, BP, CO (good for hypovolemic patients)

29
Q

CI of ketamine

A

increased intraocular pressure, Increased ICP (i.e. incracranial mass), HTN, psych

30
Q

what drug causes visual hallucinations, emergence agitation

A

ketamine

31
Q

use antisialogogue with what drug?

A

ketamine

32
Q

ketamine dose 1st v. subsequent

A 
#1 = 0.5-1 (1-2) mg/kg
#2 = (1/2 first dose) 0.5 mg/kg
33
Q

20% of patients have ___ side effect with ketamine?

A

nausea/emesis

34
Q

ketamine onset

A

<60s

35
Q

peak of ketamine

A

1-2min

36
Q

peak versed

A

2-3min

Sedation (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions