DRUGS Flashcards
Which antiemetic blocks the 5-HTS serotonin receptor and can cause extrapyramidal symptoms?
metoclopramide (another one is listed with it that is same class of drug)
What can contribute to Dilantin toxicity in a patient with diabetes mellitus?
Hypoalbuminemia (as in any pt)
Which of the following anti-epileptic drugs is the LT drug of choice for treating pts dx with convulsive status epilepticus?
Phenytoin
There is a question asking ‘which of the following factors puts the patient at risk for drug toxicity
CrCl <30 (the correct answer)
52 yo F is concerned with hormonal replacement therapy. What are the associated SE?
Gallstones, blood clots and CVA
Hormonal replacement therapy has been shown to improve what dx?
Osteoporosis
57 yo M with PMH of cardiovascular disease presents with c/o of pain in both knees that is progressively worse throughout the day. You suspect OA. What medication is contraindicated?
Celebrex r/t ARF, MI, and CV dz
Dantroline sodium/Dantrium. Tx:
Serotonin syndrome, malignant hyperthermia, neuroleptic malignant syndrome
Detrol LA– anticholinergic effects
(drying: xerostomia, constipation, dyspepsia, dry eyes, dysuria, HA
Ginseng risk
increases the risk of bleeding
Hypoalbuminemia: risk of drug toxicity
decreased binding → more free substance in blood
what does Metformin cause
lactic acidosis
what labs to watch with Methotrexate:
monitor LFTs
Metoclopramide (Reglan) S/E
tardive dyskinesia, EPS
what to monitor with NSAIDS:
creatinine, hyperkalemia
Opiate naïve, how long do you monitor
3 hours
PPI what to rule out
r/o hip fractures, increase vitamin d
Coumadin, how do you know pts understands instructions:
Getting INR checked
Renal angiogram, what med to avoid
no ACEi
Tamoxifen S/E:
(estrogen modulator) Hot flashes, menopausal symptoms, vag dryness, hair thinning/loss, menstrual irregularities, pancytopenia, ↑risk of DVT/CVA.
St John’s wort: what to watch for
decreases the effectiveness of dig, ↑r/o SSRI syndrome
Succinylcholine:
(relaxes airway for RSI) r/o malignant hyperthermia. C.I.: ↑K , intubation for Methamphetamine OD
Synthroid
Risk of MI. Ensure adequate treatment by checking TSH. S/E: alopecia
TCA overdose expected EKG finding?
Prolonged QT
What would you monitor post-op with serotonin HT3
Nausea (Zofran is a serotonin 5HT3 antagonist
What 2 herbs are associated with relieving premenstrual symptoms?
Evening primrose and black cohosh
Elderly pt takes an herbal root to help fight colds, however has a history of renal insufficiency. Which medication could exacerbate his diagnosis?
Echinacea causing nephrotoxicity
