DRUGS

Question 1

Which antiemetic blocks the 5-HTS serotonin receptor and can cause extrapyramidal symptoms?

Answer 1

metoclopramide (another one is listed with it that is same class of drug)

Question 2

What can contribute to Dilantin toxicity in a patient with diabetes mellitus?

Answer 2

Hypoalbuminemia (as in any pt)

Question 3

Which of the following anti-epileptic drugs is the LT drug of choice for treating pts dx with convulsive status epilepticus?

Answer 3

Phenytoin

Question 4

There is a question asking ‘which of the following factors puts the patient at risk for drug toxicity

Answer 4

CrCl <30 (the correct answer)

Question 5

52 yo F is concerned with hormonal replacement therapy. What are the associated SE?

Answer 5

Gallstones, blood clots and CVA

Question 6

Hormonal replacement therapy has been shown to improve what dx?

Answer 6

Osteoporosis

Question 7

57 yo M with PMH of cardiovascular disease presents with c/o of pain in both knees that is progressively worse throughout the day. You suspect OA. What medication is contraindicated?

Answer 7

Celebrex r/t ARF, MI, and CV dz

Question 8

Dantroline sodium/Dantrium. Tx:

Answer 8

Serotonin syndrome, malignant hyperthermia, neuroleptic malignant syndrome

Question 9

Detrol LA– anticholinergic effects

Answer 9

(drying: xerostomia, constipation, dyspepsia, dry eyes, dysuria, HA

Question 10

Ginseng risk

Answer 10

increases the risk of bleeding

Question 11

Hypoalbuminemia: risk of drug toxicity

Answer 11

decreased binding → more free substance in blood

Question 12

what does Metformin cause

Answer 12

lactic acidosis

Question 13

what labs to watch with Methotrexate:

Answer 13

monitor LFTs

Question 14

Metoclopramide (Reglan) S/E

Answer 14

tardive dyskinesia, EPS

Question 15

what to monitor with NSAIDS:

Answer 15

creatinine, hyperkalemia

Question 16

Opiate naïve, how long do you monitor

Answer 16

3 hours

Question 17

PPI what to rule out

Answer 17

r/o hip fractures, increase vitamin d

Question 18

Coumadin, how do you know pts understands instructions:

Answer 18

Getting INR checked

Question 19

Renal angiogram, what med to avoid

Answer 19

no ACEi

Question 20

Tamoxifen S/E:

Answer 20

(estrogen modulator) Hot flashes, menopausal symptoms, vag dryness, hair thinning/loss, menstrual irregularities, pancytopenia, ↑risk of DVT/CVA.

Question 21

St John’s wort: what to watch for

Answer 21

decreases the effectiveness of dig, ↑r/o SSRI syndrome

Question 22

Succinylcholine:

Answer 22

(relaxes airway for RSI) r/o malignant hyperthermia. C.I.: ↑K , intubation for Methamphetamine OD

Question 23

Synthroid

Answer 23

Risk of MI. Ensure adequate treatment by checking TSH. S/E: alopecia

Question 24

TCA overdose expected EKG finding?

Answer 24

Prolonged QT

Question 25

What would you monitor post-op with serotonin HT3

Answer 25

Nausea (Zofran is a serotonin 5HT3 antagonist

Question 26

What 2 herbs are associated with relieving premenstrual symptoms?

Answer 26

Evening primrose and black cohosh

Question 27

Elderly pt takes an herbal root to help fight colds, however has a history of renal insufficiency. Which medication could exacerbate his diagnosis?

Answer 27

Echinacea causing nephrotoxicity