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Psychiatry Shelf > Drugs > Flashcards

Drugs Flashcards

1
Q

Which drugs work on the mesolimbic pathway?

A

Antipsychotics

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2
Q

Which pathway is involved with extrapyramidal symptoms of drugs?

A

Nigrostriatal

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3
Q

Decreased dopamine in the tuberoinfundibular pathway causes what with boobs?

A

Gynecomastia, lactation

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4
Q

What’s the first-line treatment for narcolepsy?

A

Modafinil

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5
Q

What are 4 good maintenance treatments for bipolar?

A
  1. Lithium
  2. Valproate
  3. Lamotrigine
  4. Quetiapine
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6
Q

What are the 2 main organs that lithium affects?

A
  1. Thyroid

2. Kidneys

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7
Q

What’s a first-line monotherapy for bipolar (for patients with frequent hospitalizations or aggression etc)?

A

Lithium or valproate plus second generation antipsychotic

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8
Q

What’s the treatment for PCP intoxication?

A

Benzos

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9
Q

Which 2 antipsychotics are less likely to cause tardive dyskinesia?

A
  1. Clozapine

2. Quetiapine

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10
Q

What class of drugs can treat extrapyramidal symptoms but not TD?

A

Anticholinergics

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11
Q

What 2 drugs treat acute dystonia?

A
  1. Benztropine

2. Diphenhydramine

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12
Q

What 3 drugs treat akathisia?

A
  1. B-blocker
  2. Benzodiazepine
  3. Benztropine
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13
Q

What 2 drugs treat parkinsonism?

A
  1. Benztropine

2. Amantadine

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14
Q

What 2 drugs treat tardive dyskinesia?

A
  1. Valbenazine

2. Deutetrabenazine

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15
Q

What are the 4 adverse effects of Clozapine?

A
  1. Agranulocytosis
  2. Seizures
  3. Myocarditis
  4. Metabolic syndrome
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16
Q

What are the 2 treatments for lithium toxicity?

A
  1. IV hydration

2. Hemodialysis (if severe)

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17
Q

What do pupils look like in opioid withdrawal?

A

Dilated

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18
Q

Which 2 types of drugs can cause seizures during withdrawal?

A
  1. Alcohol

2. Benzos

19
Q

What’s the treatment for NMS after stopping the antipsychotic?

A

Restart dopamine agents; if refractory: Dantrolene or Bromo

20
Q

What kind of a drug is levodopa?

A

Dopamine precursor

21
Q

What kind of a drug is pramipexole?

A

Dopamine agonist

22
Q

Can too high of a dose of carbidopa-levodopa cause psychosis?

A

Yep

23
Q

What are 3 alternatives to amphetamines for ADHD?

A
  1. Atomoxetine
  2. Guanfacine
  3. Clonidine
24
Q

What syndrome is caused by B1 deficiency, is associated with mammillary bodies, and has anterograde amnesia and confabulations?

A

Korsakoff syndrome

25
Q

What phase of sleep do night terrors occur in?

A

N3

26
Q

What’s the pathophysiology of narcolepsy?

A

Decreased hypocretin (orexin) in lateral hypothalamus

27
Q

Antidote for benzo OD?

A

Flumazenil

28
Q

What’s the tx for cocaine OD?

A

Alpha blockers

29
Q

What kind of drug is methadone?

A

Long acting opioid agonist

30
Q

What kind of drug is buprenorphine + naloxone?

A

Partial agonist plus antagonist if injected

31
Q

What kind of drug is naltrexone?

A

Long-acting opioid antagonist used for relapse prevention

32
Q

If concerned about precipitating Wernicke-Korsakoff syndrome, what should you give immediately?

A

B1 before anything else

33
Q

What kind of drug is carbamazepine?

A

Anticonvulsive; but it can be used for schizophrenia as well

34
Q

What’s the mechanism of typical antipsychotics?

A

Block D2 receptors

35
Q

What’s the mechanism of atypical antipsychotics?

A

D2 antagonists with varied 5HT2, dopamine, and a and H1 receptor effects

36
Q

What’s the mechanism of buspirone?

A

Stimulates 5HT1A receptors

37
Q

What’s the mechanism of SSRIs?

A

Inhibit 5HT reuptake

38
Q

What’s the mechanism of SNRIs and tricyclics?

A

Inhibit 5HT and NE reuptake

39
Q

What’s the most common adverse effect of SNRIs?

A

Elevation in BP

40
Q

What class of drugs are: Selegiline, phenelzine, isocarboxyzid, and tranylcypromine?

A

MAOIs

41
Q

What’s the mechanism of buproprion?

A

Inhibits reuptake of NE and dopamine

42
Q

What’s the mechanism of mirtazapine?

A

a2 agonist

43
Q

What’s the mechanism of trazodone?

A

Blocks 5Ht2, a1, and H1 receptors; also weakly inhibits 5HT reuptake

Psychiatry Shelf (1 decks)

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