Drugs

Question 0

Methylphenidate

Answer 0

Ritalin

A stimulant

MOA: Blocks reuptake of transmitter into pre-synaptic terminal

Question 1

Citalopram

Answer 1

SSRI: one of the most common anti- depressants

Brand Name: Celexa

Question 2

Lithium

Answer 2

Used for treating bipolar disorder

Protective against suicide

Question 3

Carbamazepine

Answer 3

Anti- seizure medication

Lots of side effects and drug interactions

Question 4

Sertraline

Answer 4

Also known as Zoloft: SSRI antidepressant

Question 5

Cisplatin

Answer 5

Chemotherapy

Class: Direct DNA damaging: cross linkers

MOA: Loss of chloride ion results in unstable molecule that reacts with DNA and leads to cell cycle arrest and apoptosis

Question 6

Catecholamine

Answer 6

Organic compound derived from tyrosine featuring a benzene ring, 2 hydroxyls and amine

Ex: epinephrine, norepinephrine, and dopamine

Question 7

Amphetamine

Answer 7

A psycho-stimulant also known as 1- phenylpropan-2-amine

MOA: Increases release of neurotransmitters and blocks reuptake. Works on dopamine, norepinephrine , and serotonin

It’s derivatives include: crystal meth, and MDMA(ecstasy)

Question 8

Lorazepam

Answer 8

Used to treat anxiety, anxiety with depression, and insomnia. A benzodiazepine.

Medium duration but easier on the liver-> med abuse potential

Question 9

Imipramine

Answer 9

TCA antidepressant

Blocks reuptake (uptake 1= NET) of serotonin and norepinephrine

Question 10

Selegaline

Answer 10

Inhibits MAO-b ( blocks degradation of dopamine). Used in Parkinson’s

Question 11

Carbidopa

Answer 11

Inhibits L-AAD in periphery to maximize dopa delivery to brain. Used in Parkinson’s

Question 12

Disulfiram

Answer 12

Inhibits ALDH. Results in horrible hangover. Used to treat alcohol dependence

Shows promise in treating cocaine dependence ( raises DA, lowers NE)

Question 13

Naltrexone

Answer 13

Opiate antagonist. Used for preventing alcohol relapse (only for specific mu receptor genotype- moa unclear) and heroin

Question 14

Buprenorphine

Answer 14

Partial opiate agonist. Used for detox. Should be taken orally. Can be abused if IV use

Question 15

Suboxone

Answer 15

Buprenorphine( partial opiate agonist) and Naloxone (opiate antagonist)

Antagonist only active if IV use. Meant to prevent abuse of buprenorphine

Question 16

Bupropion 5-R

Answer 16

Originally marketed as anti-depressant. Now used for aiding in smoking cessation. More effective than nicotine substitution. Has dopaminergic properties

Question 17

Varenicline

Answer 17

Used for smoking cessation. Partial agonist at a4b2 nicotinic cholinergic receptor. Relieves craving without reward.

Very effective but side effect profile includes higher risk of CV and depression and nausea

Question 18

Topiramate

Answer 18

Anticonvulsant which is very effective in treating alcohol dependency. Has a high side effect profile because interacts with lots of Neuro transmitters

Shows promise for treating cocaine dependency (blocks ampa, increases GABA a transmission)