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Rheum > Drugs > Flashcards

Drugs Flashcards

1
Q

methotrexate

A

DMARD 2.5 mg tab, max 10 tab.

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2
Q

sulfasalazine

A

DMARD azulfidine

0.5g-1g PO divided daily, max 4g daily

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3
Q

plaquenil

A

DMARD hydroxychloroquine
200mg tabs daily
max 400mg daily

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4
Q

arava

A

DMARD leflunomide

max 20 mg daily

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5
Q

imuran

A

DMARD azathioprine
1mg/kg daily (can divide BID)
max 2.5mg daily

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6
Q

enbrel

A

TNF Inhibitor
Etanercept
SQ weekly

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7
Q

Humira

A

TNF Inhibitor
Adalimumab
SQ every 2 weeks
can increase to weekly

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8
Q

Simponi

A

TNF Inhibitor
Golimumab
SQ monthly

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9
Q

Simponi Aria

A

TNF Inhibitor
Golumumab
- RA indication only
IV 2mg/kg at 0, 4, then every 8 weeks (first one, one month later, then every 2 months)

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10
Q

Cimzia

A

TNF Inhibitor

Certolizumab pegol

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11
Q

Remicade

A

TNF Inhibitor
Infliximab
IV 3mg/kg at 0,2,6 weeks then every 4-8 weeks,
max 10mg/kg every 4-8 weeks

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12
Q

Actemra

A 
Tocilizumab
IL - 6 antagonist
IV 8mg/kg q4 weeks
Start: IV 4mg/kg with max 800mg or SQ 162 mg weekly
if weight <100kg start q 2 weeks.
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13
Q

kinaret

A

anakinra
IL 1 antagonist
SQ 100mg daily

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14
Q

Ritxan

A

Rituximab
B cell antagonist
IV 1000mg every 2 weeks in 2 doses, repeat every 16-24 weeks.
give with solumedrol and zyrtec to combat infusion rxn.

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15
Q

Zeljanz

A

tofacitinib
JAK antagonist
5mg BID PO or 11mg daily

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16
Q

Orencia

A

abatacept
decreases immature T cell activation
weight based dosing
-IV <60kg: 500mg on weeks 0, 2, 4; then every 4 weeks
-IV 60-100kg: 750mg on weeks 0, 2, 4; then every 4 weeks
-IV 100kg: 1000mg on weeks 0, 2, 4; then every 4 weeks
-SQ 125mg weekly after loading dose according to the above IV guidelines

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17
Q

Fosamax

A

alendronate
inhibits osteoclast bone resorption
70mg weekly PO

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18
Q

Actonel

A

Risedronate
inhibits osteoclast bone resorption
35mg weekly PO

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19
Q

Boniva

A

Ibandronate
Inhibits osteoclast bone resorption
150mg monthly PO

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20
Q

Evista

A

Raloxifene
SERM = estrogen agonist, prevents bone loss
60mg daily PO

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21
Q

Prolia

A

denosumab
Binds to RANKL to prevent osteoclast formation
SQ 60mg every 6 months

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22
Q

gabapentin

A

neurontin
binds to alpha2 delta 1 subunit on calcium channels in the brain to decrease excitatory neurotransmitter responsible for pain perception (nocioception)
PO 300-1200 TID, max 3600 daily
taper for d/c

23
Q

lyrica

A

pregabalin
PO 75mg BID
max 450mg

24
Q

topamax

A

topiramate
blocks sodium channels, glutamate, and cabonic anhydrase. enhances GABA,
25mg BID PO
max 100mg BID

25
Q

cymbalta

A

duloxetine
SNRI, mild inhibits DOPA reuptake,
30mg daily x 1 week, then max 60mg daily
taper for d/c

26
Q

savella

A

milnacipran
potent SNRI for only fibro
12.5mg x 1 day, 12.5 BID x 2 days then 25 mg BID x 4 days, 50 mg BID.
Max 200mg

27
Q

flexeril

A

cyclobenzaprine

5-10mg TID PO

28
Q

robaxin

A

methocarbamol
1000mg QID,
max 8000mg daily

29
Q

Skelaxin

A

metaxalone

800mg PO TID/QID

30
Q

Zanaflex

A

tizanidine
2mg q6-8hrs PRN
max 36mg

31
Q

meloxicam

A

mobic
PO 7.5mg daily
max 15

32
Q

feldene

A

piroxicam

20 mg daily

33
Q

clinoril

A

sulindac

150-200mg BID, max 400mg

34
Q

Lodine

A

etodolac

300-500mg BID, max 1000

35
Q

ketoprofen

A

PO 75mg TID, max 300mg daily

36
Q

advil

A

ibuprofen
300-800mg TID/QID
max 3200

37
Q

nalfon

A

fenoprofen
300-800mg TID/QID
max 3200

38
Q

nabumetone

A

1000-2000mg daily or BID, max 2000mg

39
Q

celebrex

A

celecoxib

inhibits cox 2

40
Q

arthrotec

A

diclofenac/misoprostol

diclofenac-inhibits cox 1+2

misoprostol - synthetic prostaglandin E1 analog replaces the protective prostaglandis consumed by DMARDS

41
Q

RA and PsA TNF inhibitors

A 
Enbrel-etanercept
Humira-adalimumab
cimzia-certolizumab pegol
remicade-infliximab
simponi-golimumab
42
Q

otezla

A 
PsA - apremilast
PDE4 antagonist
start 
10mg 1 in am x 1 day, 
10mg BID x 1 day,
10mg qam, 
20mg qpm x 1 day, 
20mg BID x 1 day, 
20mg qam, 
30mg BID
43
Q

cosentyx

A 
PsA, psoriasis, AS - secukinamab
IL 17 antagonist
SQ every 4 weeks, 
if plaque psoriasis - 300weekly
with or without loading dose
44
Q

stelara

A

ustekinumab
IL23 antagonist
SQ 45mg 0,4 then every 12 weeks (3 mos)

45
Q

Lupus meds

A

PLQ, MTX
imuran-azathioprine
atabrine-quinacrine
Benlysta-Belimumab

46
Q

atabrine

A

quinacrine
anti-protozoal
25mg up to 100mg

47
Q

benlysta

A

Belimumab

IV

48
Q

aleve

A

naproxen

49
Q

colcrys

A

colchicine

mitigare

50
Q

zylprim

A

allopurinol

51
Q

uloric

A

febuxostat

52
Q

probenicid

A

promotes uric acid excretion

53
Q

krystexxa

A

pegloticase

Rheum (5 decks)

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