Drugs

Question 1

Hydroxyzine

Answer 1

Antihistamine used for GAD

H1 and 5-HT2a antagonist

Adverse effects due to anti-histamine, anti-cholinergic, and anti-dopaminergic properties

Question 2

Quetiaprine

Answer 2

Atypical antipsychotic with 5-HT2A activity used for GAD

SE include anti muscarinic, alpha-adrenergic, and dopamine receptors

Question 3

Midazolam

Answer 3

Benzo with very quick onset of action and short half life that can be used as sedation prior to surgery

Question 4

Suvorexant

Answer 4

Antagonist at OX1 and OX2 to decrease sleep latency and increase sleep periods

Risk of abuse and dependence

Question 5

Histone deacetylase inhibitors

Answer 5

Potential anti-depressant based on the idea that acetylation promotes transcription, so removing acetyl groups inhibits transcription

Decreased depressive symptoms with transcription