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Neuropharmacology > Drugs > Flashcards

Drugs Flashcards

1
Q

How do benzos work?

A

Enhance GABAa

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2
Q

Clonazepam

A

Benzo used in epilepsy

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3
Q

Vigabatrin

A

Inhibits GABA transiminase

EPILEPSY

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4
Q

Tiagabine

A

GABA re-uptake inhibitor

EPILEPSY

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5
Q

Phenytoin

A

Inhibits VG Na+ Channels
Binds to inactive state, inner pore of NaV1.2. Only blocking firing neurons.

EPILEPSY

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6
Q

Volproate

A

Inhibits Na channels
Indirectly inhibits GABA transiminase

EPILEPSY

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7
Q

Alprazolam

A

Benzo

ANXIETY

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8
Q

Busiprone

A

5-HT1a partial agonist
Coupled to Gi

ANXIETY

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9
Q

Pregabalin

A

GABA analogue

ANXIETY

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10
Q

Bromocriptine

A

DA agonist

PARKINSON’S

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11
Q

Entacapone

A

COMT inhibtor
COMT breaks down DA

PARKINSON’S

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12
Q

Benztropine

A

Muscarinic Receptor Blocker

PARKINSON’S

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13
Q

Donepezil, Galantamine, Rivastigmine

A

AChE inhibitors
Rivastingmine non-selective

ALZHEIMER’S

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14
Q

Memantine

A

NDMA antagonist

ALZHEIMER’S

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15
Q

Setraline

A

SSRI

DEPRESSION

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16
Q

Phenelzine

A

MAOI

DEPRESSION

17
Q

Clomipramine

A

TCA

DEPRESSION

18
Q

Haloperidol

A

Typical antipsychotic. D2 antagonist

SCHIZOPHRENIA

19
Q

Clozapine

A

Atypical antipsychotic. Non-selective for D1/D2

SCHIZOPHRENIA

20
Q

Temazepam

A

Benzo for insomnia

SLEEP DISORDERS

21
Q

Zopiclone, Zolpidem

A

GABAa enhancer

SLEEP DISORDER

22
Q

Promethazine

A

Antihistamine
Inhibits H1 receptors (inhibiting Gq)

SLEEP DISORDERS

23
Q

Modafinil

A

Narcolepsy

Unknown MOA

SLEEP DISORDERS

24
Q

Pizotifin

A

5-HT2 antagonists
Prevent 5-HT and NO release

MIGRAINE

25
Q

Sumitriptan

A

5-HT1 agonists
Prevent NO –> prevent vasodilation

MIGRAINE

26
Q

Ergotamine

A

activates 5-HT1 receptors

MIGRAINE

27
Q

Topiramate

A

Block VGCC
Inc. action of GABAa
Inhibit AMPA

MIGRAINE

Neuropharmacology (1 decks)

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