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Renal Endocrine > Drugs > Flashcards

Drugs Flashcards

1
Q

furosemide

A

Treatment for: diuretic
Class: loop diuretic
Site of action: thick ascending limb of LOH
MOA: NKCC inhibitor

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2
Q

bumetanide

A

Treatment for: diuretic
Class: loop diuretic
Site of action: thick ascending limb of LOH
MOA: NKCC inhibitor

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3
Q

ethancrynic acid

A

Treatment for: diuretic
Class: loop diuretic
Site of action: thick ascending limb of LOH
MOA: NKCC inhibitor

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4
Q

cholorothiazide

A

Treatment for: diuretic
Class: thiazide type
Site of action: distal tubule
MOA: Na/Cl transporter inhibitor.

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5
Q

benzothiadiazine

A

Treatment for: diuretic
Class: thiazide type
Site of action: distal tubule
MOA: Na/Cl transporter inhibitor.

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6
Q

metolazone

A

Treatment for: diuretic
Class: thiazide type
Site of action: distal tubule
MOA: Na/Cl transporter inhibitor.

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7
Q

spironolactone

A

Treatment for: diuretic
Class: K+ sparing
Site of action: collecting ducts
MOA: antagonist of aldosterone

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8
Q

amiloride

A

Treatment for: diuretic
Class: K+ sparing
Site of action: collecting ducts
MOA: antagonist of ENaC

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9
Q

triamtirene

A

Treatment for: diuretic
Class: K+ sparing
Site of action: collecting ducts
MOA: antagonist of ENaC

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10
Q

acetazolamide

A

Treatment for: diuretic
Class: carbonic anhydrase inhibitor
Site of action: proximal tubule
MOA: inhibits carbonic anhydrase, thus reducing H2CO3 within the cells and consequently HCO3-/Na transporter reabsorption

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11
Q

methazolamide

A

Treatment for: diuretic
Class: carbonic anhydrase inhibitor
Site of action: proximal tubule
MOA: inhibits carbonic anhydrase, thus reducing H2CO3 within the cells and consequently HCO3-/Na transporter reabsorption

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12
Q

mannitol

A

Treatment for: diuretic
Class: osmotic diuretic
Site of action: all tubule segments
MOA: creates an osmotic gradient for water to flow out of the cell.

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13
Q

metformin

A

Treatment for: diabetes
Class: Biguanid
MOA: gluconeogenesis inhibitor
Side effects: possible lactic acidosis

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14
Q

novolog/humalog

A

Treatment for: diabetes
Class: insulin analog
MOA: stimulates uptake of glucose into cells. short acting.

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15
Q

lantus

A

Treatment for: diabetes
Class: insulin analog
MOA: stimulates uptake of glucose into cells. long acting.

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16
Q

glipizide

A

Treatment for: diabetes
Class: Sulfonylureas
MOA: K-channel blocker in pancreas. stimulates insulin release from beta cells

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17
Q

glimepiride

A

Treatment for: diabetes
Class: Sulfonylureas
MOA: K-channel blocker in pancreas. stimulates insulin release from beta cells

18
Q

sitagliptin (januvia)

A

Treatment for: diabetes
MOA: glucagon suppressor. stimulates insulin release by blocking glucagon
Class: DPP4 inhibitor

19
Q

acarbose

A

Treatment for: diabetes
MOA: slows down glucose absorption. glucosidase inhibitor.
Side effects: flatulence and diarrhea

20
Q

gliflozin

A

Treatment for: diabetes

MOA: SGLT2 inhibitor. blocks renal glucose uptake in the proximal tubule

21
Q

Pioglitazone

A

Treatment for: diabetes
Class: thiazolidines
MOA: increases insulin sensitivity. activates PPARs to increase sensitivity to insulin in muscle/fat.
Side effects: hepatitis or liver failure

22
Q

levothyroxine

A

Treatment for: hypothyroidism
Class: T4 analog
MOA: replaces T4, converted to T3 within the body
Side effects: palpitation, bone tissue loss

23
Q

methimazole

A

Treatment for: hyperthyroidism
Class: Thioamide
MOA: thyroperoxidase inhibitor. blocks synthesis to T3/T4

24
Q

propylthiouracil

A

Treatment for: hyperthyroidism
Class: Thioamide
MOA: thyroperoxidase inhibitor. blocks synthesis to T3/T4

25
Q

Probenecid

A

Treatment for: gout

MOA: inhibitor of proximal tubule uric acid reabsorption

26
Q

prednisolone

A

Treatment for: non-toxic thyroiditis
Class: corticosteroid
MOA: immunosuppressant

27
Q

pegvisomant

A

Treatment for: acromegaly/gigantism
Class: GHR inhibitor
MOA: blocks GH receptor activaiton

28
Q

bromocriptine

A

Treatment for: pituitary tumors and prolactinomas
Class: ergoline
MOA: activated DOPA receptors to down-regulate pituitary activity

29
Q

hydrocortisone

A

Treatment for: Addison’s Disease
Class: corticosteroid
MOA: acts as a cortisol analogue. immunosuppressant

30
Q

allopurinol

A

Treatment for: gout

MOA: suicide inhibitor of xanthine oxidase

31
Q

lispro

A

Treatment for: diabetes
Class: insulin analog
MOA: stimulates uptake of glucose into cells. short acting.

32
Q

aspart

A

Treatment for: diabetes
Class: insulin analog
MOA: stimulates uptake of glucose into cells. short acting.

33
Q

glulisine

A

Treatment for: diabetes
Class: insulin analog
MOA: stimulates uptake of glucose into cells. short acting.

34
Q

glargine

A

Treatment for: diabetes
Class: insulin analog
MOA: stimulates uptake of glucose into cells. long acting.

35
Q

determir

A

Treatment for: diabetes
Class: insulin analog
MOA: stimulates uptake of glucose into cells. long acting.

36
Q

rosiglitazone

A

Treatment for: diabetes
Class: thiazolidines
MOA: increases insulin sensitivity. activates PPARs to increase sensitivity to insulin in muscle/fat.
Side effects: hepatitis or liver failure

37
Q

glyburide

A

Treatment for: diabetes
Class: Sulfonylureas
MOA: K-channel blocker in pancreas. stimulates insulin release from beta cells

38
Q

miglitol

A

Treatment for: diabetes
MOA: slows down glucose absorption. glucosidase inhibitor.
Side effects: flatulence and diarrhea

39
Q

GLP-1

A

Treatment for: diabetes
MOA: stimulates biosynthesis of insulin
Class: incretin

40
Q

Octreotide

A

somatostatin analogue

41
Q

bromocriptine

A

dopamine agonist

Renal Endocrine (2 decks)

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