Drugs

Question 1

In epilepsy, there is too much neuronal stimulation of ____and_____

Answer 1

Glutamate and Asparate

Question 2

Phenytoin treats all types of seizures except

Answer 2

Absence

Question 3

Which drug treats only absence seizures?

Answer 3

Ethosuximide

Question 4

Ethosuximide MOA:

Answer 4

Inhibits T-type calcium channels

Question 5

Adverse effect of ethosuximide

Answer 5

Blood dyscrasias

Question 6

Phenobarbital treats which type of seizures?

Answer 6

Tonic-Clonic (Grand Mal)

Question 7

Which drugs treats only focal seizures?

Answer 7

Topiramate

Question 8

Phenytoin MOA:

Answer 8

Na Ch inactivation decreases calcium influx

Question 9

Carbamazepine MOA:

Answer 9

Na Ch inactivation decreases NMDA receptors

Question 10

Valproic Acid MOA:

Answer 10

Inhibits Na ch and T-type calcium in thalamus increasing GABA

Question 11

This drug causes Fetal Hydantoin Syndrome in the fetus.

Answer 11

Phenytoin

Question 12

Drug of choice in trigeminal neuralgia.

Answer 12

Carbamazepine

Question 13

Phenytoin adverse effects (5)

Answer 13

Gingival hyperplasia 
Hirsutism 
Rickets
Folate megaloblastic anemia
SLE-like rxn

Question 14

Valproic Acid may cause ______ which may be fatal

Answer 14

Pancreatitis

Question 15

3 adjuncts to anti-epileptics

Answer 15

Lamotrigine
Gabapentin
Pregabalin

Question 16

Lamotrigine MOA:

Answer 16

Inhibits glutamate release and blocks Na ch

Question 17

Reason to withdraw lamotrigine administration

Answer 17

Stevens-Johnson syndrome rash

Question 18

Drugs of choice for status epilepticus

Answer 18

Lorazepam, diazepam, phenytoin, Phenobarbital IV

Question 19

Phenytoin had what order kinetics?

Answer 19

Zero

Question 20

Phenobarbital is contraindicated in patients with a history of

Answer 20

Porphyria

Question 21

Diazepam/lorazepam MOA:

Answer 21

Increase frequency of chloride channel opening

Question 22

Stiripentol MOA:

Answer 22

Increase GABA in brain and inhibits lactate dehydrogenase

Question 23

Drugs of choice in Severe myoclonic epilepsy of infancy

Answer 23

Stiripentol, clobazam, valproate

Question 24

If you take a benzodiazepine with an anti-epileptic drug you should take

Answer 24

Flumazenil

Question 25

Drug of choice for febrile seizures

Answer 25

Diazepam rectal