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Ageing > Drugs > Flashcards

Drugs Flashcards

1
Q

pharmacokinetics

A

bodies action on the drug

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2
Q

pharmacodynamic

A

drugs action on the body

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3
Q

what kind of environment do acidic drugs need for absoption

A

acidic

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4
Q

what kind of environment do basic drugs need for absoption

A

basic

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5
Q

name acidic drugs

A

phenytoin
aspirin
penicillin

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6
Q

name basic drugs

A

diazepam

morphine

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7
Q

what binds to basic drugs

A

alpha 1 acid glycoprotein

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8
Q

what binds to acidic drugs

A

albumin

elderly have low albumin but high A1 AG

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9
Q

what drugs are increased in volume distribution in elderly

A

lipophilic drugs eg diazepam

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10
Q

why is there a lower volume distribution of hydrophilic drugs in elderly

A

decreased body water

eg lithium

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11
Q

what is reduced in terms of metabolism of drugs in elderly

A

decreased first pass metabolism

reduced liver function

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12
Q

what is different in elderly in terms of excretion

A

lower gfr

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13
Q

what drugs may need increased doses in elderly

A

beta blockers

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14
Q

how should dosing be done in elderly in general

A

in general need lower doses

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15
Q

examples of drugs with narrow therapeutic window

A 
warfarin
lithium
digoxin
gentamicin
vancomycin
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16
Q

common side effect of amlodipine

A

oedema

17
Q

grapefruit juice

A

statin

18
Q

metronidazole

A

alcohole

19
Q

cranberry juice

A

warfarin

20
Q

antibiotics which interacts badly with statin

A

clarithromycin

21
Q

hyperkalaemia

A

ACE

spironolactone

22
Q

deficiency that causes wernickes

A

B1 thiamine

23
Q

urinary retention in PDH

A

decongestants or anticholinergics

24
Q

lower seizure threshold

A

antipsychotics

25
Q

contraindicated in asthma

A

beta blockers

26
Q

what should you start with an opiod in elderly

A

lactulose or senna

27
Q

what interferes with thyroxine absoption

A

calcium

28
Q

contraindications for triptans

A

IHD
uncontrolled hypertension
lithium
SSRI

Ageing (2 decks)

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