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Psychopharmacology > Drugs > Flashcards

Drugs Flashcards

1
Q

Disorders for antidepressants

A 
OCD:SSRI, TCA
Panic: All
Eating disorders: SSRI, TCA, MAOI
Social Phobia: MAOI, SSRI
PTSD: SSRI, TCA
IBS: SSRI, TCA
Enuresis: TCA
Neuropathic pain: TCA
Migraines: TCAs, SSRIs, buproprion
Smoking cessation: Buproprion
Autism: SSRI
PMS(PDD): SSRI
Depressive bipolar episode: SSRI, buproprion
Insomnia: Mirtazapine, TCAs
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2
Q

TCAs

A

*SNRIs
*High side effects, lethal dose.
*Imipramine, Amytriptyline, Timipramine, Nortriptyline
Desipramine, Clomipramine, Doxepin

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3
Q

TCA SE

A
  • Anihistaminergic: Sedation
  • Antiandrenergic: Orthostasis, tachycardia, arrhythmia
  • Antimuscarinic: Dry mouth, constipation, urinary retention, blurred vision, tachycardia
  • Weight gain
  • OD lethality
  • CCC- Convulsions, cardiotoxicity, coma
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4
Q

Notriptyline

A

TCA least likely to cause orthostasis

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5
Q

Desipramine

A

Least anticholinergic, least sedating

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6
Q

Clomipramine

A

Most serotonin specific, OCD treatment

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7
Q

TCA toxicity signs

A

Widened QRS >100ms

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8
Q

TCA toxicity treatments

A

Sodium bicarb

-Na loading and alkalinization altering myocardial effects.

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9
Q

MAOI MOA etc.

A
  • Prevent inactivation of NE, Serotonin, dopamine, and tyramine
  • MAO-A serotonin deactivator
  • MAO-B NE/Epi deactivator
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10
Q

MAOIs

A

Phenelzine, Tranylcypromine, isocarboxazid

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11
Q

MAOI SE

A

Orthostasis, drowsiness, weight gain, sexual dysfunction, dry mouth, sleep dysfunction

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12
Q

Serotonin Syndrome

A

MAOI + SSRI

  • 1st lethargy, restlessness, confusion, flushing, diaphoresis, tremor, myoclonus
  • 2nd hyperthermia, hypertonicity, rhabdo, renal failure, convulsions, coma, death
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13
Q

Hypertensive crisis

A

MAOI and Tyramine rich foods/sympathomimetics

Buildup of catecholamines

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14
Q

SSRIs info

A

Anxiety, depression, OCD, PMS

  • low SE
  • No food restriction
  • No overdose
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15
Q

SSRIs

A 
Fluoxetine
Sertraline
Paroxetine
Fluvooxamine
Citalopram
Escitalopram
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16
Q

SSRI SE

A 
Sexual dysfunction
GI disturbance
Insomnia
HA
Anorexia/weightloss
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17
Q

Fluoxetine

A

Longest halflife with active metabolites- no taper needed

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18
Q

Sertraline

A

highest GI problems

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19
Q

Paroxetine

A

Most serotonin selective- Stimulant properties

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20
Q

Fluvoxamine

21
Q

Citalopram

A

used in Europe first

22
Q

Escitalopram

A

Fewer SE, much more expensive

23
Q

Atypicals

A

SNRI- Effexor
NDRI-Buproprion
SARI- Trazodone depression/anxiety, sedation and boners
NASAs- refractory depression in little old ladies–> weight gain poss agranulocytosis

24
Q

Antipsychotics

A

Traditional- dopamine blockers

Atypicals- Dopamine and serotonin receptor blockers

25
High potency traditional SE
Mainly EPSE *Parkinsonism *Akasthisia- anxiety and restlessness *Dystonia- painful contractions *hyperprolactinemia- impotence, osteoporosis Tx: Amantadine-dopamine, benadryl antihist, benztropine antimusc
26
Antidepressant categories
TCAs, MAOIs, SSRIs, Atypical (DNRI, SNRI etc.)
27
High potency traditionals
*Higher EPS *more NMS *Lower antimuscarinic/antihistaminergic Haloperidol*, fluphenazine*, trifluoperazine, Perphenazine, Pimozilde, *IM forms
28
Low potency traditionals
Chlorpromazine, Thoridazine | *More antimuscarinic, antihistaminergic, less EPS
29
Low Potency traditional SE
* anti HAM- sedation, orthostasis, cardiac abnormal, sexual dysfunction * weight gain * Liver enzymes * ophtho- chlorpromazine deposits, thoridizine iris pigment * derm- chlorpromazine gray skin * Lower seizure threshold
30
Dopamine effect on prolactin and ACH
Inhibits both
31
Tardive dyskenesia
>6 mos use of neuroleptic | involuntary movements caused by ^^^ dopamine receptors and vvvv Ach
32
NMS
FALTER fever, autonomic instability, leukocytosis, tremor, elevated CPK, rigidity Tx with dantroline, amantidine, bromocriptine
33
Atypical Antipsychotics info
anti dopaminergic and serotonergic * fewer SE * rarely TD NMS, EPSE * treat negative sx
34
Atypical Antipsychotics
Clozapine, risperidone, quetiapine, olanzapine, ziprasidone, aripiprazole
35
Atypical SE
Some antiHAM
36
Agranulocytosis and siezure SE
Clozapine (weekly blood draw)
37
Hyperlipidemia, glucose intolerance, and weight gain, liver toxicity
Olanzipine
38
Weight gain and cataracts
Quetiapine
39
Atypicals with mania FDA approval
Quetiapine and Ziprasadone
40
Mood stabilizers gen info
``` Prevent mania Potentiate refractory antidepressants potentiate antipsychotics enhance alcohol abstinance Treat agressin and inpulsive behavior *lithium, carbamazepine,Valproic acid ```
41
Lithium
Mood stabalizer * 5-7 day onset * therapeutic .7-1.2 * toxic>1.5 * lethal>2
42
Lithium SE:
Tremor, sedation, ataxia, thirst, mettalic taste, poyuria, edema, weight gain, gi disturbance, thyroid dysfunction, NEPHROGENIC DI Toxi: AMI, tremors, convulsion, death
43
Carbamazepine
blocks sodium channels * 5-7 day onset * leukopenia, aplasic anemia, agranulocytsis, hyponatremia, elevated liver enzymes, teratogen, drowsiness, skin rash, ataxia (CBC and LFT NEEDED)
44
Valproic acid
MEch unknown, increases CNS GABA | *SE: Hepatotox, thrombocytopenia, neural tube teratogen, alopecia, hemorrhaghic pancreatitis, sedation, weight gain
45
Lithium level affectors
``` NSAIDS: V Aspirin Dehydration:^ Salt depravation:^ Decreased renal function:^ Diuretics ```
46
Anxiolytic/hypnotics uses
Anxiety, muscle spasm, seizures, sleep disorders, alcohol withdrawl, anesthesia induction
47
Benzos
Safety at high doses *tolerance and dependance risks Long acting: Chlorodiazepoxide, diazepam, flurazepam Med Acting: Alprazolam, clonazepam, lorazepam, temazepam Short acting: Oxazepam, triazolam
48
Buspirone
``` Alternative for anxiety disorder Slower onset of action anxiolytic at 5HT1A partial agonist Does not otentiate alcohol CNS depression Low abuse potential ```
49
Propranolol
Beta blocker- ANS panic attacks, performance anxiety, palp, sweating, and tachycardia

Psychopharmacology (1 decks)

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