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Psychopharmacology > Drugs > Flashcards

Drugs Flashcards

1
Q

Disorders for antidepressants

A 
OCD:SSRI, TCA
Panic: All
Eating disorders: SSRI, TCA, MAOI
Social Phobia: MAOI, SSRI
PTSD: SSRI, TCA
IBS: SSRI, TCA
Enuresis: TCA
Neuropathic pain: TCA
Migraines: TCAs, SSRIs, buproprion
Smoking cessation: Buproprion
Autism: SSRI
PMS(PDD): SSRI
Depressive bipolar episode: SSRI, buproprion
Insomnia: Mirtazapine, TCAs
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2
Q

TCAs

A

*SNRIs
*High side effects, lethal dose.
*Imipramine, Amytriptyline, Timipramine, Nortriptyline
Desipramine, Clomipramine, Doxepin

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3
Q

TCA SE

A
  • Anihistaminergic: Sedation
  • Antiandrenergic: Orthostasis, tachycardia, arrhythmia
  • Antimuscarinic: Dry mouth, constipation, urinary retention, blurred vision, tachycardia
  • Weight gain
  • OD lethality
  • CCC- Convulsions, cardiotoxicity, coma
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4
Q

Notriptyline

A

TCA least likely to cause orthostasis

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5
Q

Desipramine

A

Least anticholinergic, least sedating

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6
Q

Clomipramine

A

Most serotonin specific, OCD treatment

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7
Q

TCA toxicity signs

A

Widened QRS >100ms

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8
Q

TCA toxicity treatments

A

Sodium bicarb

-Na loading and alkalinization altering myocardial effects.

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9
Q

MAOI MOA etc.

A
  • Prevent inactivation of NE, Serotonin, dopamine, and tyramine
  • MAO-A serotonin deactivator
  • MAO-B NE/Epi deactivator
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10
Q

MAOIs

A

Phenelzine, Tranylcypromine, isocarboxazid

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11
Q

MAOI SE

A

Orthostasis, drowsiness, weight gain, sexual dysfunction, dry mouth, sleep dysfunction

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12
Q

Serotonin Syndrome

A

MAOI + SSRI

  • 1st lethargy, restlessness, confusion, flushing, diaphoresis, tremor, myoclonus
  • 2nd hyperthermia, hypertonicity, rhabdo, renal failure, convulsions, coma, death
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13
Q

Hypertensive crisis

A

MAOI and Tyramine rich foods/sympathomimetics

Buildup of catecholamines

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14
Q

SSRIs info

A

Anxiety, depression, OCD, PMS

  • low SE
  • No food restriction
  • No overdose
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15
Q

SSRIs

A 
Fluoxetine
Sertraline
Paroxetine
Fluvooxamine
Citalopram
Escitalopram
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16
Q

SSRI SE

A 
Sexual dysfunction
GI disturbance
Insomnia
HA
Anorexia/weightloss
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17
Q

Fluoxetine

A

Longest halflife with active metabolites- no taper needed

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18
Q

Sertraline

A

highest GI problems

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19
Q

Paroxetine

A

Most serotonin selective- Stimulant properties

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20
Q

Fluvoxamine

A

OCD only

21
Q

Citalopram

A

used in Europe first

22
Q

Escitalopram

A

Fewer SE, much more expensive

23
Q

Atypicals

A

SNRI- Effexor
NDRI-Buproprion
SARI- Trazodone depression/anxiety, sedation and boners
NASAs- refractory depression in little old ladies–> weight gain poss agranulocytosis

24
Q

Antipsychotics

A

Traditional- dopamine blockers

Atypicals- Dopamine and serotonin receptor blockers

25
Q

High potency traditional SE

A

Mainly EPSE
*Parkinsonism
*Akasthisia- anxiety and restlessness
*Dystonia- painful contractions
*hyperprolactinemia- impotence, osteoporosis
Tx: Amantadine-dopamine, benadryl antihist, benztropine antimusc

26
Q

Antidepressant categories

A

TCAs, MAOIs, SSRIs, Atypical (DNRI, SNRI etc.)

27
Q

High potency traditionals

A

Higher EPS
more NMS
*Lower antimuscarinic/antihistaminergic
Haloperidol, fluphenazine, trifluoperazine, Perphenazine, Pimozilde,

*IM forms

28
Q

Low potency traditionals

A

Chlorpromazine, Thoridazine

*More antimuscarinic, antihistaminergic, less EPS

29
Q

Low Potency traditional SE

A
  • anti HAM- sedation, orthostasis, cardiac abnormal, sexual dysfunction
  • weight gain
  • Liver enzymes
  • ophtho- chlorpromazine deposits, thoridizine iris pigment
  • derm- chlorpromazine gray skin
  • Lower seizure threshold
30
Q

Dopamine effect on prolactin and ACH

A

Inhibits both

31
Q

Tardive dyskenesia

A

> 6 mos use of neuroleptic

involuntary movements caused by ^^^ dopamine receptors and vvvv Ach

32
Q

NMS

A

FALTER
fever, autonomic instability, leukocytosis, tremor, elevated CPK, rigidity
Tx with dantroline, amantidine, bromocriptine

33
Q

Atypical Antipsychotics info

A

anti dopaminergic and serotonergic

  • fewer SE
  • rarely TD NMS, EPSE
  • treat negative sx
34
Q

Atypical Antipsychotics

A

Clozapine, risperidone, quetiapine, olanzapine, ziprasidone, aripiprazole

35
Q

Atypical SE

A

Some antiHAM

36
Q

Agranulocytosis and siezure SE

A

Clozapine (weekly blood draw)

37
Q

Hyperlipidemia, glucose intolerance, and weight gain, liver toxicity

A

Olanzipine

38
Q

Weight gain and cataracts

A

Quetiapine

39
Q

Atypicals with mania FDA approval

A

Quetiapine and Ziprasadone

40
Q

Mood stabilizers gen info

A 
Prevent mania
Potentiate refractory antidepressants
potentiate antipsychotics
enhance alcohol abstinance
Treat agressin and inpulsive behavior
*lithium, carbamazepine,Valproic acid
41
Q

Lithium

A

Mood stabalizer

  • 5-7 day onset
  • therapeutic .7-1.2
  • toxic>1.5
  • lethal>2
42
Q

Lithium SE:

A

Tremor, sedation, ataxia, thirst, mettalic taste, poyuria, edema, weight gain, gi disturbance, thyroid dysfunction, NEPHROGENIC DI

Toxi: AMI, tremors, convulsion, death

43
Q

Carbamazepine

A

blocks sodium channels

  • 5-7 day onset
  • leukopenia, aplasic anemia, agranulocytsis, hyponatremia, elevated liver enzymes, teratogen, drowsiness, skin rash, ataxia (CBC and LFT NEEDED)
44
Q

Valproic acid

A

MEch unknown, increases CNS GABA

*SE: Hepatotox, thrombocytopenia, neural tube teratogen, alopecia, hemorrhaghic pancreatitis, sedation, weight gain

45
Q

Lithium level affectors

A 
NSAIDS: V
Aspirin
Dehydration:^
Salt depravation:^
Decreased renal function:^
Diuretics
46
Q

Anxiolytic/hypnotics uses

A

Anxiety, muscle spasm, seizures, sleep disorders, alcohol withdrawl, anesthesia induction

47
Q

Benzos

A

Safety at high doses
*tolerance and dependance risks
Long acting: Chlorodiazepoxide, diazepam, flurazepam
Med Acting: Alprazolam, clonazepam, lorazepam, temazepam
Short acting: Oxazepam, triazolam

48
Q

Buspirone

A 
Alternative for anxiety disorder
Slower onset of action
anxiolytic at 5HT1A partial agonist
Does not otentiate alcohol CNS depression
Low abuse potential
49
Q

Propranolol

A

Beta blocker- ANS panic attacks, performance anxiety, palp, sweating, and tachycardia

Psychopharmacology (1 decks)

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