Drugs

Question 1

Temozolomide

Answer 1

Damage DNA; crosslinking; Alkylating agent
Non-specific
PO or IV
BBB? Yes, need activation
Similar to Cyclophosphamide
Potential Side Effects: Secondary neoplasm, rapidly diving cells prone

Question 2

Vincristine

Answer 2

Interrupts mitosis; Inhibits microtubule formation
M-phase specific
IV
BBB? Yes
Similar to Paclitaxol
Side effects: Immunosuppression, hair loss, etc…

Question 3

Carmustine

Answer 3

Alkylating agent (DNA and RNA)	
Non-specific	
IV or intracranial wafer	
BBB? <50% poor	
Similar to Cyclophosphamide	
Adverse effects: Infection, meningitis

Question 4

Cyclophosphamide

Answer 4

Nitrogen mustard alkylating agent
Non-specific
PO, IV
BBB? Yes

Question 5

Doxorubicin

Answer 5

Intercalates DNA
Non-specific
IV
BBB? No

Question 6

Methotrexate

Answer 6

Inhibit nucleotide synthesis; Antifolate
S Phase Specific
PO, IV, IM, SQ, intrathecal
BBB? No

Question 7

Etoposide

Answer 7

Cytotoxic topo II inhibitor (strand breaks)
S-phase specific
IV
BBB? Yes

Question 8

Ara-C

Answer 8

Prevent DNA synthesis; Inhibit DNA synthesis enzymes; Pyrimidine

Question 9

Busulfan

Answer 9

Damage DNA; Crosslinking

Question 10

Cisplatin

Answer 10

Damage DNA; Crosslinking; Platinum

Question 11

Cyclophosphamide/ifosfamide

Answer 11

Damage DNA; Crosslinking; Alkylating agent

Question 12

Fludarabine

Answer 12

Prevent DNA synthesis; Inhibit DNA synthesis enzymes; Purine

Question 13

5-fluorouracil

Answer 13

Prevent DNA synthesis; Inhibit nucleotide synthesis; Pyrimidine

Question 14

Paclitaxel

Answer 14

Interrupts mitosis; Promotes microtubule formation

Question 15

Dexamethasone

Answer 15

Immunosuppresant
Reconstitutes the BBB by decreasing swelling
Antiemetic

Question 16

Crossing the blood brain barrier?????

Answer 16

Small Lipophilic Efflux Pump?
TMZ yes yes nope
BCNU no somewhat meh
Vincristine no yes pumped out
Amphoterecin no yes pumped out

Question 17

Adverse affects of the Gliadel wafer?

Answer 17

Can cause infection, this can be bad because immune system is weakened by dexamethasone and/or chemo drugs and body can’t fight off on it’s own…..sometimes need to treat with antifungal or antibacterial….

Question 18

Adverse affects from DNA alkylating agents?

Answer 18

Secondary neoplasms (B cells can be targeted because they divide rapidly)