Drugs

Question 0

Omeprazole inhibits what liver enzyme?

Answer 0

CYP2C19

Question 1

Omeprazole is a __?

Answer 1

PPI

Question 2

Omeprazole’s major drug interaction is with what other drug? What is that drug used for?

Answer 2

Clopidogrel (used to inhibit clotting[for MI risk pts])

Question 3

Iansoprazole is a __?

Answer 3

PPI

Question 4

Pantoprazole is a ___?

Answer 4

PPI

Question 5

Rabeprazole is a ___?

Answer 5

PPI

Question 6

Eseprazole is a ___?

Answer 6

PPI

Question 7

Dexlansoprazole is a ___?

Answer 7

PPI

Question 8

PPI MOA?

Answer 8

Suicide inhibition (covalent biding to) H+/K+ ATPase on the luminal membrane of parietal cells

Question 9

Antimicrobial therapy for treatment of H. Pylori induced ulcers?

Answer 9

PPI+amoxicillin+clarithromycin

Question 10

How many times a day do you take a PPI? Why?

Answer 10

Once- suicide inhibitor

Question 11

Cetidine is a ___?

Answer 11

H2 r antagonist

Question 12

Ranitidine is a ___?

Answer 12

H2 r antagonist

Question 13

Famotidine is a ___?

Answer 13

H2 r antagonist

Question 14

Nizatidine is a ___?

Answer 14

H2 r antagonist

Question 15

Where are H2 r antagonists absorbed?

Answer 15

I’m the SI

Question 16

How are H2 r antagonists eliminated?

Answer 16

Renal excretion

Question 17

What does renal impairment require in terms of H2 r antagonist therapy?

Answer 17

Dose reduction

Question 18

Which H2 r antagonist has most extensive side effects?

Answer 18

Cimitidine

Question 19

Are antimuscarinics useful for isolated acid reduction?

Answer 19

They are rarely used due to side effects

Question 20

Sucralfate is a

Answer 20

Mucosal binding agent that binds preferentially to the ulcer, and has no acid-neutralizing effects

Question 21

Subgallate is a

Answer 21

Mucosal protective agent with weak acid neutralizing capacity

Question 22

Subcitrate is a

Answer 22

Mucosal protective agent with weak acid neutralizing capacity

Question 23

Subnitrate is a

Answer 23

Mucosal protective agent with weak acid neutralizing capacity

Question 24

Subsalicylate is a

Answer 24

Mucosal protective agent with weak acid neutralizing capacity

Question 25

What do mucosal protective agents do?

Answer 25

Increase mucous secretion, thus coating ulcer, also cause detachment of H. Pylori

Question 26

Sucralfate side effects?

Answer 26

Dry mouth, constipation

Question 27

Sucralfate interferes with what drugs?

Answer 27

Tetracycline, phenytoin, digoxin, and cimetidine

Question 28

Misprostol is a

Answer 28

Mucosal protective agent

Question 29

Misprostol is used how often for ulcers? Why?

Answer 29

Rarely, due to side effects. Works as a PGE1 analogue, and there are tons of receptors for dat crap. Only good for NSAID-induced ulcers, and we don’t even really use it for that.

Question 30

Antacid MOA?

Answer 30

Bases neutralize acid in stomach, increase pH.

Question 31

Antacid effectiveness compared to H2 r blockers?

Answer 31

About the same

Question 32

Antacid side effects?

Answer 32

Alkaluria–> Kidney stones
Maybe Na+ content too high for CHF pts
Lots of drug interaction effects

Question 33

Sodium Bicarbonate is a

Answer 33

An antacid

Question 34

Calcium carbonate is a

Answer 34

An antacid

Question 35

Calcium carbonate causes

Answer 35

Hypercalcemia and rebound HCl secretion

Question 36

Milk of magnesia is a

Answer 36

An antacid

Question 37

Milk of magnesia causes

Answer 37

Blood Mg increase, osmotic effects, increased intestinal motility

Question 38

Aluminum compounds cause

Answer 38

Constipation

Question 39

What two antacids may be mixed to counter side effects?

Answer 39

Magnesium and aluminum