Drugs Flashcards

1
Q

CYP3A

A

Substrates: Cyclosporine mechanism: genetically less important than other drug metabolism genes b/c activity continuous and unimodal

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2
Q

Ketoconazole, grapefruit juice inhibit….

A

CYP3A

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3
Q

Rifampin induces…

A

CYP3A

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4
Q

CYP2D6

A

Substrates: Tricyclic antidepressants and codeine (activates codeine->morphine)

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5
Q

Quinidine, Fluoxetine, Paroxetine inhibit…

A

CYP2D6

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6
Q

CYP2C9

A

Substrates: Warfarin

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7
Q

20% of caucasians need lower dose of ….. because they are poor metabolizers

A

Warfarin

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8
Q

NAT

A

Modifies risk of cancers though differences in acetylation of carcinogens, Important in Phase II pathway

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9
Q

Isoniazid for TB mechanism

A

Acts on NAT

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10
Q

TMPT

A

5% of kids with ALL (leukemia) poor metabolizers (absent activity)–> will KILL child (immunosuppression) if don’t test for it (functional assay)

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11
Q

6-mercaptopurine, 6-thioguanine

A

Acts on TMPT

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12
Q

G6PD

A

X-linked enzyme -Deficient individuals susceptible to hemolytic anemia after sulfa or dapsone drug exposures

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13
Q

Sulfonamide antibiotics, dapsone are substrates for…

A

G6PD

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14
Q

VKORC1

A

VKORC1 reduces vitamin K so that vitamin K can be recycled and used to make more coagulation factors

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15
Q

Warfarin acts on…

A

VKORC1

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