Drugs Flashcards
CYP3A
Substrates: Cyclosporine mechanism: genetically less important than other drug metabolism genes b/c activity continuous and unimodal
Ketoconazole, grapefruit juice inhibit….
CYP3A
Rifampin induces…
CYP3A
CYP2D6
Substrates: Tricyclic antidepressants and codeine (activates codeine->morphine)
Quinidine, Fluoxetine, Paroxetine inhibit…
CYP2D6
CYP2C9
Substrates: Warfarin
20% of caucasians need lower dose of ….. because they are poor metabolizers
Warfarin
NAT
Modifies risk of cancers though differences in acetylation of carcinogens, Important in Phase II pathway
Isoniazid for TB mechanism
Acts on NAT
TMPT
5% of kids with ALL (leukemia) poor metabolizers (absent activity)–> will KILL child (immunosuppression) if don’t test for it (functional assay)
6-mercaptopurine, 6-thioguanine
Acts on TMPT
G6PD
X-linked enzyme -Deficient individuals susceptible to hemolytic anemia after sulfa or dapsone drug exposures
Sulfonamide antibiotics, dapsone are substrates for…
G6PD
VKORC1
VKORC1 reduces vitamin K so that vitamin K can be recycled and used to make more coagulation factors
Warfarin acts on…
VKORC1