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Psych Clerkship > Drugs > Flashcards

Drugs Flashcards

1
Q

CYP450 inducers

A

smoking
carbamazepine
barbiturates
st. john’s wart

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2
Q

CYP450 inhibitors

A 
fluvoxamine
fluoxetine
paroxetine
duloxetine
sertraline
(all SSRIs except duloxetine)
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3
Q

Fluoxetine

A 
SSRI
longest halflife (weekly dosing available)
-->no need to taper
safe in pregnancy + kids
common sleep changes and anxiety
can elevate antipsychotic levels
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4
Q

Sertraline

A

SSRI
highest risk for GI disturbance
very few interactions
common sleep changes

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5
Q

Paroxetine

A

SSRI
highly protein bound –> DDIs
more anti-chol effects
short halflife –> withdrawal

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6
Q

Fluvoxamine

A

SSRI
only for use in OCD
N/V common
lots of DDIs

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7
Q

Citalopram

A

SSRI
fewest DDIs
fewer sexual AEs

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8
Q

Escitalopram

A

SSRI
enantiomer of citalopram
expensive

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9
Q

Venlafaxine

A

SNRI
Tx of depression, anxiety d/o, ADHD
can cause HTN

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10
Q

Duloxetine

A

SNRI
Tx of depression and neuropathic pain
can cause liver AEs

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11
Q

Bupropion

A

NDRI
NO sexual side effects
increases risk of seizures
CI in seizure or eating d/o and patients on MAOI

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12
Q

Trazodone

A

Serotonin receptor antagonists and agonists

  • refractory MDD or depression with anxiety/insomnia
  • no sex AEs
  • no effect on REM sleep
  • can cause orthostatic hypoTN, priapism, sadation
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13
Q

Nefazodone

A

Serotonin receptor antagonists and agonists

  • refractory MDD or depression with anxiety/insomnia
  • no sex AEs
  • no effect on REM sleep
  • can cause orthostatic hypoTN, priapism, sedation
  • BBW for liver failure
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14
Q

Mirtazapine

A

alpha2-receptor antagonist

  • tx of refractory major depression
  • use in patients that need weight gain
  • Can cause sedation
  • no sex AEs
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15
Q

Amitriptyline

A

TCA (tertiary amine)

- Tx of chronic pain, migraine, insomnia

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16
Q

Imipramine

A

TCA (tertiary amine)

- Tx of enuresis and panic d/o

17
Q

Clomipramine

A

TCA (tertiary amine)

- Tx of OCD

18
Q

Doxepin

A

TCA (tertiary amine)

- Tx of chronic pain, insomnia

19
Q

Nortriptyline

A

TCA (secondary amine)

  • least likely to cause orthostatic hypoTN
  • tx of chronic pain
20
Q

Desipramine

A

TCA (secondary amine)

  • least sedating
  • least antichol
21
Q

Amoxapine

A

Tetracyclic antidepressant

  • may cause EPS
  • side effect profile similar to typical antipsych
22
Q

Maprotiline

A

tetracyclic antidepressant

- high rates of seizure, arrhythmia, fatal OD

23
Q

3 Cs of tricyclics

A

cardiotoxicity
convulsions
coma

24
Q

Phenelzine

A

MAOI

25
Q

Tranylcypromine

A

MAOI

26
Q

Isocarboxazid

A

MAOI

27
Q

OCD

A

SSRI (fluvoxamine)

TCAs (clomipramine)

28
Q

Panic d/o

A

SSRIs, TCAs (imipramine), MAOI

29
Q

Eating d/o

A

SSRI (high doses), TCAs, MAOIs

30
Q

Dysthymia

A

SSRI

31
Q

Social phobia

A

SSRIs, TCAs, MAOIs

32
Q

GAD

A

SSRIs, SNRIs (venlafaxine

Psych Clerkship (1 decks)

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