Drugs Flashcards
1
Q
Nitisinone
A
AKA orafidin, used to treat type I tyrosinemia.
It reduces the synthesis of deleterious tyrosine metabolites by inhibiting pheylketone dioxygenase in Tyr degradation (2nd enzyme out of 5)
2
Q
What drugs inhibit Complex I of the ETC (aka NADH-CoQ reductase)?
A
METFORMIN, Rotenone, Amytal
3
Q
What durg inhibits Complex III of ETC?
A
Antimycin A
Complex III aka cytochrome c reductase
4
Q
What drug inhibits Complex IV of ETC?
A
Cyanide and Carbon Monoxide
Complex IV Aka cytochrome c oxidase
5
Q
What does the drug 2,4-dinitrophenol do?
A
It is a weight loss drug that’s so intense it can cause death
6
Q
What are oliogmycin and atractyloside used for?
A
Oligomycin: inhibits ATP synthase (not used clinically)
Atracyloside: inhibits ATP/ADP translocase
