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Med Micro > Drugs > Flashcards

Drugs Flashcards

1
Q

Beta-Lactams

A 
antimicrobial
peptidoglycan synthesis
all bacteria
penicillins, cephalosporins
combined with clavulanic acid - competitive inhibitor of beta-lactamase
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2
Q

Glycopeptides

A

antimicrobial
peptidoglycan synthesis
all bacteria
vancomycin

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3
Q

Isoniazid

A

antimicrobial
acid fast cell wall
blocks synthesis of mycolic acid

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4
Q

Ethambutol

A

antimicrobial
acid fast cell wall
blocks arabinogalactan synthesis

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5
Q

Aminoglycosides

A

antimicrobial
protein synthesis (70S ribosome)
streptomycin, gentamicin

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6
Q

Tetracyclines

A 
antimicrobial
protein synthesis (70S ribosome)
tetracycline, doxycycline
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7
Q

Macrolides

A

antimicrobial
protein synthesis (70S ribosome)
erythromycin, azithromycin

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8
Q

Oxazolinidones

A

antimicrobial
protein synthesis (70S ribosome)
linezolid

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9
Q

Quinolones

A

antimicrobial
nucleic acid synthesis
ciprofloxacin, levofloxacin

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10
Q

Rifampins

A

antimicrobial
nucleic acid synthesis
rifabutin, rifaximin

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11
Q

Metronidazole

A

antimicrobial
nucleic acid synthesis
targets anaerobic bacteria & parasites

antiparasitic
inhibits DNA replication
nitroimidazoles

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12
Q

Clofazimine

A

antimicrobial
nucleic acid synthesis
targets mycobacterium

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13
Q

Sulfonamides

A

antimicrobial
anti-metabolites
inhibits folic acid biosynthetic pathway
bacteria capable of using exogenous thymine are intrinsically resistant

antiparasitic
inhibits folic acid biosynthesis

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14
Q

Trimethoprim

A

antimicrobial
anti-metabolites
inhibits folic acid biosynthetic pathway
blocks DHF –> THF

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15
Q

Sulfamethoxazole

A

antimicrobial
anti-metabolites
inhibits folic acid biosynthetic pathway
blocks PABA –> DHF

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16
Q

Polymyxins

A

antimicrobial
cytoplasmic membrane function inhibitor
colistin, polymyxin B

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17
Q

Bacitracin

A

antimicrobial

cytoplasmic membrane function inhibitor

18
Q

Enfuviritide

A

antiviral
blocks attachment/penetration
fusion inhibitor

19
Q

Amantadine

A

antiviral

blocks uncoating

20
Q

Rimantadine

A

antiviral

blocks uncoating

21
Q

AZT

A

antiviral
blocks nucleic acid synthesis
base analog

22
Q

Ribavirin

A

antiviral
blocks nucleic acid synthesis
inhibits nucleotide biosynthesis

23
Q

Lipopeptides

A

antimicrobial
cytoplasmic membrane function inhibitor
daptomycin

24
Q

Acyclovir

A

antiviral
blocks nucleic acid synthesis
inhibits DNA Pol

25
Q

Ganciclovir

A

antiviral
blocks nucleic acid synthesis
inhibits DNA Pol

26
Q

Nevirapine

A

antiviral
blocks nucleic acid synthesis
inhibits reverse transcriptase

27
Q

Interferon-alpha

A

antiviral

blocks protein synthesis

28
Q

Ritonavir

A

antiviral
blocks assembly
protease inhibitor

29
Q

Elvitegravir

A

antiviral
blocks assembly
integrase inhibitor

30
Q

Zanamivir

A

antiviral
blocks release
inhibits neuraminidase or hemagglutinin

31
Q

Oseltamivir

A

antiviral
blocks release
inhibits neuraminidase or hemagglutinin

32
Q

Polyenes

A

antifungal
affects integrity of plasma membrane
pore formation and ion leakage
amphoteracin B, nystatin

33
Q

Azoles

A

antifungal
inhibits plasma membrane synthesis
blocks synthesis of ergosterol
ketoconazole, fluconazole

34
Q

Echinocandins

A

antifungal
inhibits cell wall synthesis
blocks synthesis of glucan
caspofungin

35
Q

Fungal Base analogs

A

antifungal
inhibits nucleic acid synthesis
flucytosine

36
Q

Chloroquine

A

antiparasitic
inhibits DNA replication
aminoquinoline analogs group

37
Q

Pentamidine

A

antiparasitic
inhibits DNA replication
diamidines group

38
Q

Pyrimethamine

A

antiparasitic
inhibits folic acid biosynthesis
pyrimethamines group

39
Q

Paramomycin

A

antiparasitic
inhibits protein synthesis
aminoglycosides group

40
Q

Mebendazole/Albendazole

A

antiparasitic
inhibits transport
benzimidazole group

41
Q

Piperazine

A

antiparasitic
inhibits neuromuscular action
(neuro-mediator –> helminths)

42
Q

Ivermectin

A

antiparasitic
inhibits neuromuscular action
(neuro-mediator –> helminths)

Med Micro (5 decks)

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