Drugs

Question 0

Complication of intramuscular pethidine

Answer 0

Reduce CTG variability

Question 1

What does suxamethonium do?

Answer 1

1. Rapid acting muscle relaxant
2. Mimics acetylcholine at NMJ but undergoes hydrolysis much more slowly than acetylcholine - depolarisation is therefore prolonged which results in neuromuscular blockade

Question 2

Chloral hydrate

Answer 2

Sedating premedication - used in paediatrics

Can be given orally

Question 3

Atropine

Answer 3

Administered to infants and neonates prior to anaesthesia and surgery to reduce risk of inducing bradycardia

Question 4

Lidocaine

Answer 4

1. Class 1b anti arrhythmic drug
2. Reversibly blocks activated sodium channels
3. Addition of adrenaline causes vasoconstriction and slows down absorption

Question 5

Bupivacaine

Answer 5

More lipophilic than lidocaine and so has a longer duration of action

Question 6

Thiopentone sodium

Answer 6

IV induction agent

SE: marked hypotension, anaphylaxis, bronchospasm

Question 7

Halothane

Answer 7

Volatile inhalational anaesthetic
Well tolerated and non irritant
1/30000- severe hepatotoxicity 50% mortality
Can be responsible for malignant hyperthermia (1/150000) AD-IV dantrolene sodium