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CVPR Test 2 > Drugs > Flashcards

Drugs Flashcards

1
Q

Heparin:

  • Drug type?
  • M of A?
  • Onset?
  • Absorption?
  • Elimination?
  • Lab Test?
  • Adverse effects?
  • Pregnancy?
  • DDI’s?
  • Overdose treatment?
  • Uses?
A
  • Unfractionated
  • Binds AT3 –> inactivates 2a and 10a
  • Rapid
  • IV/SC (Parenteral)
  • Dose dependent reticuloendothelial system
  • PTT
  • Bleeding/ thrombocytopenia
  • Safe
  • NSAIDs
  • Protamine
  • UA/ACS/ venous thromboembolism
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2
Q

Enoxaparin:

  • Drug type?
  • M of A?
  • Onset?
  • Absorption?
  • Elimination?
  • Lab Test?
  • Adverse effects?
  • Pregnancy?
  • DDI’s?
  • Overdose treatment?
  • Uses?
A
  • Low molecular weight
  • Binds AT3 –> inactivates 10a
  • 3-5 hours
  • IV/SC (Parenteral)
  • Renal clearance
  • Not needed
  • Bleeding/ thrombocytopenia
  • Safe
  • NSAIDs
  • Protamine
  • ACS/ venous thromboembolism/ UA
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3
Q

Warfarin:

  • M of A?
  • Onset?
  • Absorption?
  • Elimination?
  • Lab Test?
  • Adverse effects?
  • Pregnancy?
  • DDI’s?
  • Overdose treatment?
  • Uses?
A
  • Inhibits liver synthesis of vit k dep factors (2,7,9,10)
  • Delayed
  • Oral
  • Hepatic (CYP2C9)
  • INR
  • Bleeding/ skin necrosis
  • Not safe
  • NSAIDs; Inducers = Less effect
  • Phytonadione
  • A-fib/ venous thromboembolism (propholaxis)
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4
Q

Dabigatran:

  • Drug type?
  • M of A?
  • Onset?
  • Absorption?
  • Elimination?
  • Lab Test?
  • Adverse effects?
  • Pregnancy?
  • DDI’s?
  • Overdose treatment?
  • Uses?
A
  • Direct 2a inhibitor
  • 1-3 hours
  • Oral prodrug
  • Renal
  • Not monitored
  • Bleeding/ gastritis
  • Category C
  • Decreased effect with glycoprotein inducers
  • None
  • A fib
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5
Q

Rivaroxaban:

  • Drug type?
  • M of A?
  • Onset?
  • Absorption?
  • Elimination?
  • Lab Test?
  • Adverse effects?
  • Pregnancy?
  • DDI’s?
  • Overdose treatment?
  • Uses?
A
  • Direct 10a inhibitor
  • 2-4 hours
  • Oral
  • Hepatic
  • Not monitored
  • Bleeding
  • Category C
  • Decreased effect with glycoprotein inducers
  • None
  • A fib
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6
Q

Aspirin:

  • M of A?
  • Onset?
  • Absorption?
  • Elimination?
  • Adverse Effects?
  • Safety?
  • DDI’s?
  • Uses?
A
  • Low dose = selective inhibition of platelet COX-1 irreversible
  • Rapid
  • Oral
  • Hepatic
  • Gastric upset/ bleeding
  • Pregnancy C/D
  • Bleeding with anticoagulants
  • Acute MI-instable angina; PCI; MI prevention
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7
Q

Clopidogrel:

  • M of A?
  • Onset?
  • Absorption?
  • Elimination?
  • Adverse Effects?
  • Safety?
  • DDI’s?
  • Uses?
A
  • Inhibit plt ADP receptor; irreversible
  • 2-5 hours
  • Oral Prodrug
  • Activated by CYP/ renal elim
  • Bleeding; dyspepsia; gastritis
  • Pregnancy B
  • Bleeding with anticoagulants
  • Acute MI-instable angina; PCI
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8
Q

Abeiximab:

  • M of A?
  • Onset?
  • Absorption?
  • Elimination?
  • Adverse Effects?
  • Safety?
  • Uses?
A
  • Blocks plt G2b/3a receptor
  • Rapid
  • Parentral infusion
  • renal
  • Bleeding
  • Category C
  • PCI
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9
Q

Eptifibatide:

  • M of A?
  • Onset?
  • Absorption?
  • Elimination?
  • Adverse Effects?
  • Safety?
  • DDI’s?
  • Uses?
A
  • Blocks plt G2b/3a receptor
  • Rapid
  • Parentral infusion
  • renal
  • Bleeding
  • Category C
  • PCI
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10
Q

Tirofiban:

  • M of A?
  • Onset?
  • Absorption?
  • Elimination?
  • Adverse Effects?
  • Safety?
  • DDI’s?
  • Uses?
A
  • Blocks plt G2b/3a receptor
  • Rapid
  • Parentral infusion
  • renal
  • Bleeding
  • Category C
  • PCI
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11
Q
  • Teplase/ ase drugs

- Adverse Effects

A
  • Plasminogen –> plasmin

- Bleeding

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12
Q

Nifedipine

  • Drug type?
  • M of A?
  • Myocardial O2 Supply effect?
  • Myocardial O2 Demand effect?
  • Elimination?
  • AR?
A
  • Calcium channel blocker
  • Don’t know
  • Increase coronary flow
  • Decrease SP (most), Decrease inotropy, increase HR
  • CYP450
  • Hypotension, HA, peripheral edema
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13
Q

Diltiazam

  • Drug type?
  • M of A?
  • Myocardial O2 Supply effect?
  • Myocardial O2 Demand effect?
  • Elimination?
  • AR?
A
  • Calcium blocker
  • Decrease conduction in SA/AV and myocytes
  • Increase
  • Decrease HR (a lot), decrease inotropy and SP
  • CYP450
  • Hypo, brady, peripheral edema
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14
Q

Verapamil

  • Drug type?
  • M of A?
  • Myocardial O2 Supply effect?
  • Myocardial O2 Demand effect?
  • Absorption?
  • Elimination?
  • AR?
  • Notes?
A
  • Calcium blocker
  • Decrease conduction in SA/AV and myocytes
  • Increase
  • Decrease HR, SP, Inotropy
  • CYP450
  • Hypo, brady, CHF
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15
Q

Nitroglycerin

  • Drug type?
  • M of A?
  • Myocardial O2 Supply effect?
  • Myocardial O2 Demand effect?
  • Absorption?
  • AR?
A
  • Nitrate
  • NO –> cGMP –> vasodil
  • Increase
  • Increase HR, Decrease SP, Decrease LV volume a lot
  • IV/SL/TD
  • Orthostatic hypo/ tolerance
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16
Q

Oral Nitrates

  • Drug type?
  • M of A?
  • Myocardial O2 Supply effect?
  • Myocardial O2 Demand effect?
  • Absorption?
  • Elimination?
  • AR?
  • Notes?
A
  • Nitrate
  • NO –> cGMP –> vasodil
  • Increase
  • Increase HR, Decrease SP, Decrease LV volume a lot
  • PO
  • Orthostatic hypo/ tolerance
17
Q

Metroprolol

  • Drug type?
  • Effect?
  • Vasodilator?
A
  • Beta blocker
  • Decrease HR, inotropy, SP, increases LV volume
  • No
18
Q

Atenolol

  • Drug type?
  • Effect?
  • Vasodilator?
A
  • Beta blocker
  • Decrease HR, inotropy, SP, increases LV volume
  • No

CVPR Test 2 (1 decks)

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