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10. Asthmas > Drugs > Flashcards

Drugs Flashcards

1
Q

Drug classes use for short term management

A
  • Short acting beta-agonist (min)

- PO/IV corticosteroids (hours)

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2
Q

Drugs belong to SABA

  • Agents
  • MOA
  • ADEs
A
  • Albuterol
  • Fenoterol
  • Levalbuterol
  • MOA: activates adenylate cyclase which increase cAMP (antagonism of bronchoconstriction)
  • ADEs: palpitation, tachycardia, tremor, light-headedness, nervousness, HA and nausea
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3
Q

Xopenex

  • Class:
  • Dose/age
  • Expiration
    • Open up foil
    • Open up but leave in foil
A

Lavalbuterol

  • Form: HFA, Neb
  • Class: SABA
  • > 12 y.o: 0.63 mg TID
  • 6-12 y.o: 0.31 mg TID
  • Open up foil: good for 1 wk
  • Open up but leave in foil: good for 2 weeks

Xopenex HFA MDI

  • Class: SABA
  • Dose: 2inh (90mcg) q4-6h or 1 inh q4h
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4
Q
  • 1st line for persistent asthma:

- ADEs of inhaled corticosteroids

A
  • Corticorsteroid is 1st line for persistent asthma in adults and children. It have high anti-inflammatory effects

ADEs

  • Oral candidiasis, dysphonia, cough
  • To prevent: use spacer device and rinse mouth after
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5
Q

Aerospan

  • Form
  • Age limited:
A

Flunisolide

  • Form: HFA
  • Age limited: >/= 6 y.o
  • Come with built in space => no need to rec a spacer
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6
Q

Veramyst

  • Indication
A

Fluticasone furoate

  • Indication: allergic rhinitis, allergic conjunctivitis
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7
Q

Flonase

  • Indication
A

Fluticasone propionate

  • Indication: Allergic rhinitis
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8
Q

Dymista

  • Indication
A

Fluticasone + Azelastine

  • Indication: Allergic rhinitis
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9
Q

Alvesco

  • Age
  • Indication
A

Ciclesonide - Prodrug

  • Age: for greater than 12 y.o
  • Indication: Asthma
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10
Q

Omnaris

  • Dose
  • Indication
  • Ketoconazole
A

Ciclesonide

  • Omnaris: 2 spray per nostril QD
  • Indication: Allergic rhinitis
    => Ketoconazole increase systemic [ ] may lead to adrenal suppression
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11
Q

NasalCrom OTC

A

Cromolyn Nasal Sol’n

  • Class: Mast cell stabilizer
  • Indication: allergic rhinitis
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12
Q

Opticrom

  • Indication
A

Cromolyn

  • Indication: allergic conjuctivitis for year round rhinitis
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13
Q

Servent diskus

  • Class
A

Salmeterol DPI

Class: LABA

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14
Q

Foradil

  • Form:
  • Indication
  • Storage
A

Formoterol

  • Form: DPI
  • Prevention of exercise induced: 1 puff 10 min prior to exercise
  • Refrigerate the dry powder cap => dose BID
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15
Q

**Advair

  • Dose:
  • Exp after opened foil
A

Salmeterol + Fluticasone

  • Form: Diskus and HFA
  • After foil open: food for 1 month
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16
Q

**Symbycort

  • Form:
  • Indication
  • Exp after opened foil wrap
  • Age of use:
A

Formoterol + Budesonide: MDI

  • Asthmas & COPD maintenance
  • 2 puffs BID
  • The foil wrap protects if from moisture: after open is only good for 90 days
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17
Q

Dulera

  • Form
A

Formoterol + Mometasone:

  • Form: MDI
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18
Q

Singulair

  • Class
  • Indication
  • Frequency
A

Montelukast

  • Anti Leukotriences. Preceptor antagonist
  • Indication: allergy, asthma, exercise induce asthma
  • Frequency: QPM
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19
Q

Accolate

  • Class
  • Indicaiton
  • Adm
A

Zafirlukast

  • Anti-Leukotriences
  • Indication: ppx/tx of chronic asthma
  • Adm: BID on empty stomach (accolate = eat later)
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20
Q

Zyflo CR

  • Class
  • Indication
  • And
  • Monitor
A

Zileuton

  • Anti Leukotriences
  • Indicaiton: ppx/tx of chronic asthma
  • Adm: BID with Foods
  • Monitor: LFTs
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21
Q

Xolair

  • ADE:
  • Monitor:
  • Indication
  • Frequency
A

Omalizumab

  • Malignancies; anaphylaxis
  • Monitor: IgE and Eosinophril
  • Indication: allergic asthma, chronic idiopathic urticaria. Not for acute asthma
  • Frequency: 2-4 weeks SC
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22
Q

Inhaler w/ Lactose

A
  • Pulmicort Flexhaler
  • Serevent diskus
  • Flovent diskus
  • Asmanex
  • Advair Diskus
  • Foradil
  • Spiriva
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23
Q

Tornalate

  • Class
  • Indication
A

Bitolterol

  • Class B2 - Agonist
  • Indication: for preterm labor
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24
Q

Metaprel
ProMeta

  • Class
  • Indication
A

Metaproterenol

  • Class: beta-2 agonist
  • Indication: bronchoconstriction
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25
Q

Brethine

  • Indication
  • SE risk:
A

Terbutaline

  • Class: beta-2 agonist
  • Indication: suppress contraction
  • ORAL: should not use for preterm tx: risk of cardiac problem. Have not shown to be effective
  • Injectable: should NOT use > 2-3 days for suppressing contraction due to serious maternal heart problems & death
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26
Q

Common agents use to treat Preterm Labor

A
  • Magnesium sulfate (MgSO4)
  • Indomethacin
  • Nifedipine
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27
Q

Makena

  • Dose
  • Indication
A

Hydroxyprogesterone caproate

  • Dose: IM once a week from 16th to 37th week of pregnancy
  • Indication: preterm pregnancy
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28
Q

Drugs use for prevention of exercise induced bronchoconstriction

A
  • LABA
  • Salmetrol
  • Formoterol: 1 puff 10 min prior to exercise
  • Montelukast
  • Cromolyn (Instal)
  • Singulair: 10mg PO 2H before exercise
29
Q

Open foil expiration date:

  • Xopenex Nebulizer
  • Servent Diskus
  • Advair
  • Formoterol (Foradil) DPI:
  • Symbicort (budesonide & formoterol)
  • Combivent Respimat
  • Tudorza Pressair (Aclidinium):
  • Brovana (arformoterol neb)
A
  • Xopenex Nebulizer: Open up foil plastic good for 1 week & opened foil but left inside good for 2 weeks
  • Servent Diskus: 6 weeks
  • Advair: 1 months
  • Formoterol (Foradil) DPI: 4 months from date of dispense (same as for Pradexa)
  • Symbicort (budesonide & formoterol): after open, only good for 90 days
  • Combivent Respimat: Write discard date on the label of the inhaler 3 months from the date the cartridge is inserted or when put on pharmacy label
  • Tudorza Pressair (Aclidinium): discard when 60 counter goes to 0 or 45 days after open or taking it out of the sealed pouch
  • Brovana (arformoterol neb): up to 6 weeks at RT
30
Q

Which DPI can be dose QPM once daily or BID

A
  • Asmanex - Mometasone
31
Q

Strength for the following meds:

  • Advair:
  • Symbicort
A
  • Advair: 100/50; 250/50; 500/50 (Steroid change but LABA stays same)
  • Symbicort: 80 mcg/4.5mcg; 160 mcg/4.5 mcg
32
Q

In asthma and COPD med, all medications are in mcg excepto two med, which are they:

A
  • Theophyllin

- Xolair

33
Q

Ventolin

  • Brand/Form
  • Dose
A

Albuterol

  • Form: HFA
  • Dose: 1-2 puffs Q4-6H prn
34
Q

Proventil

  • Generic/Form
  • Dose
A

Albuterol

  • Form: HFA
  • Dose: 1-2 puffs Q4-6H prn
35
Q

ProAir

  • Generic/Form
  • Dose
A

Albuterol

  • Form: HFA
  • Dose: 1-2 puffs Q4-6H prn
36
Q

AccuNeb

  • Generic/Form
A

Albuterol

  • Form: Neb Sol’n
37
Q

VoSpire

Generic/Dose

A

Albuterol Tab

  • Dose: 4-8 mg PO Q12H Max 16mg Q12H
38
Q

Albuterol Tab

  • Form
A
  • MDI
  • Syrup 2mg/5mL
  • IR: 2, 4 mg tab
  • ER: 4, 8 mg
39
Q

QVAR

  • Form
  • Dose
  • Space:
A

Beclomethasone HFA

Adult dose:

  • 40mcg 1-4 puffs BID
  • 80 mcg 1-2 puffs BID

5-11 years
- 40 mcg: 1-2 puffs BID

  • No need spacer b/c the particle is small & will deposit into the lung
40
Q

Beconase AQ

  • Indication:
  • Frequency
A

Beclomethasone

  • Indication: allergy rhinitis
  • Frequency: BID
41
Q

Qnasl

  • Indication:
  • Frequency
A

Beclomethasone

  • Indication: Allergy rhinitis
  • Frequency: 2 spray into each nostril QD
  • For 12 y.o or older
  • Prime 4x
42
Q

Pulmicord Flexhalder

  • Form
  • How to use it
A

Budesonide

  • Form: Dry powder => no need a spacer or shake
  • Inhale quick forceful inspiration
43
Q

Pulmicort Respules

  • Form
  • Age limited
A

Budesonide

  • Form: Nebulizer
  • Age: as young as 12 mo old
44
Q

Rhinocort

  • Indication
A

Budesonide

  • Allergic rhinitis
45
Q

Entocort EC

  • Indication
  • Dose
  • Avoid
A

Budesonide

  • Indication: Crohn’s Disease
  • Dose: 9mg PO QD
  • Avoid: grapefruit juice
46
Q

Uceris

  • Indication
  • Dose
  • Avoid
A

Budesonide

  • Indication: ulcerative colitis
  • Dose: 9mg PO QD in AM
  • Avoid: grapefruit juice
47
Q

Asmanex Twisthaler

  • Generic/form
A

Mometasone

  • Form: dry powder
48
Q

Nasonex

  • Indication
  • Dose
A

Mometasone

  • Indication: allergic rhinitis
  • Dose: 2 prays in each nostril daily
49
Q

Elocon

  • Form
A

Mometasone

  • Form: topical apply QD
50
Q

Flovent

  • Form
A

Fluticasone

  • Form: MDI
51
Q

Flovent Rotadisk

  • Form
A

Fluticasone

  • Form: DPI
52
Q

Advair

A

Salmeterol + Flovent Rotadisk

53
Q

Arnuity Ellipta

  • Form
  • Frequency
  • Age
A

Fluticasone

  • Form: DPI QD
  • Age: > 12 y.o
54
Q

Zetonna

  • Dose
  • Indication
  • Ketoconazole
A

Ciclesonide

  • Zetonna: 1 spray/nostril QD
  • Indication: Allergic rhinitis
    => Ketoconazole increase systemic [ ] may lead to adrenal suppression
55
Q

Flo-Pred

A

Prednisolone

56
Q

Millipred

A

Prednisolone

57
Q

Prelone

A

Prednisolone

  • Contain EtOH
58
Q

Pediapred

A

Prednisolone

59
Q

Orapred

A

Prednisolone ODT

60
Q

Veripred 20

A

Prednisolone

61
Q

Corticosteroid equivalent

A
  • Cortisone 25mg
  • Hydrocortisone 20mg
  • Prednisolone 5mg
  • Prednisone 5mg
  • Methylprednisolone 4mg
  • Triamcinolone 4mg
  • Dexamethasone 0.75mg
62
Q

Alocril

A

Nedocromil

  • I: allergic conjunctivitis
63
Q

Elixophyllin

  • Form
  • MOA
  • Dose
A

Theophylline - methylxanthines

  • Form: Elixir = disulfram rxn
  • MOA: Increase cAMP & cGMP
  • Dose: 300-400mg/d. Max 900mg/d
    Swallow as a whole w/ full glass of water. Do not crush
64
Q

Theo-24

A

Theophylline - methylxanthines

65
Q

Theochron ER-12H

A

Theophylline - methylxanthines

66
Q

Theophylline - methylxanthines

Adult level:
Children level:

A

Adult level: 5-15 mcg/mL

Children level: 5-10 mcg/mL

67
Q

Theophylline - Aminophylline conversion

A

Theophylline = 80% of aminophylline dose

68
Q

Nasocort

A

Triamcinolone

10. Asthmas (1 decks)

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