Drugs

Question 1

Warfarin

Answer 1

Coumadin (VKA)

• INR goal: 2-3

Question 2

Pradaxa

• Frequency

Answer 2

Dabigatran

• # 1 Rec by ACCP. No lab monitoring. No dietary considerations.
• BID

Question 3

Xarelto

• Frequency

Answer 3

Rivaroxaban

• No lab monitoring
• No dietary consideration
• QD

Question 4

What is the MOA of:

• Class I
• Class II:
• Class III:
• Class IV:

Answer 4

• Class I: Na channe blocker
• Class II: Beta blockers
• Class III: K channel blockers
• Class IV: Ca++ Channel blockers

Question 5

Drugs belong to Class IA:

Answer 5

QDAP

• Quinidine
• Disopyramide
• Amiodarone
• Procainamide
  => Atrial & V. arrhythmias

Question 6

Drugs belong to Class IB

Answer 6

PM L

• Phenytoin
• Lidocaine
• Mexiletine
  => V. arrhythmias

Question 7

Drugs belong to class IC

Answer 7

PMF

• Propafenone
• Moricizine
• Flecainide
  => V. Arrhythmias

Question 8

Drugs belong to class III

Answer 8

DAD IS

• Ibutilide
• Amiodarone
• Sotalol
• Dofetilide
• Dronedarone: Multaq

Question 9

Drugs belong to class II

Answer 9

BB: rate control

• Esmolol (Brevebloc): short t1/2 => easily reverse
• Propranolol (inderal): 1mg IV; lipid soluble, not B1 selective
• Labetalol
• B1-selective: AMEBBA (Atenolol, Metroprolol, Esmolol, Bisoprolol, Betaxolol, Acebutolol

Question 10

Antidote for BB

Answer 10

Glucagon

Question 11

Quinidine

• Indication:
• Therapeutic level:
• ADEs

Answer 11

• Quinidine sulfate 83% & Quinidine gluconate 62%
• I: arrhythmias (PO), life threatening malaria (IV)
• Level: 2-5 mcg/mL
• QT prolongation, diarrhea, ringing in the ear, thrombocytopenia

Question 12

Norpace

• Indication:
• ADEs

Answer 12

Disopyramide phosphate

• I: ventricular arrhythmia. Use only in life threatening. Incr mortality in non-life threaten
• ADEs: severe anticholinergic, hypoTN, GI

Question 13

Pronestyl

• Active metabolite
• Level
• ADEs

Answer 13

Procainamide

• N-acetylprocainamide: NAPA
• Level: 4-10 mcg/mL
• ADEs: Lupus like syndrome, hypoTN, bradycardia, agranulocytosis, diarrhea

Question 14

Xylocaine

• Route
• SE

Answer 14

Lidocaine

• 1-5 mcg/mL
• Can only give IM/IV due to poor PO BA
• ADEs: SZ, lightheaded

Question 15

Mexiletine is give PO or IV or IM

Answer 15

PO

Question 16

Rythmol

Answer 16

Propafenone

Question 17

Tambocor

Answer 17

Flecainide

Question 18

Corvert

Answer 18

Ibutilide

Question 19

Cordarone/Pacerone

• Brand:
• Indication:

Answer 19

Amiodarone

• I: Life threatening V. arrhythmia
• Unapproved: Refractory a.fib

Question 20

Amiodarone HCl premixed injection

Answer 20

Nexterone

Question 21

Multaq

Answer 21

Dronedarone

Question 22

Betapace

Betapace AF

Answer 22

Sotalol

=> do not substitute each other

Question 23

Tikosyn

Answer 23

Dofetilide

Question 24

What is Dofetilide (Tykosyn) restriction?

Answer 24

• Available only to hospital & cardiologist who have received Tilosyn education program
• Pharmacist must be registered w/ TIPS (Tkosyn in Pharmacy System)
• Rx must stamped w/ TIPS system, and initiated and dated by pharmacist

Question 25

Adenocard

• T1/2

Answer 25

Adenosine

• T1/2: 10 sec

Question 26

Mg is use for?

Answer 26

Torsades de pointes

Question 27

VF/Pulseless VT Tx Algorithm

Answer 27

• Shock(360J) =>Drug =>Shock=>Drug
• VAsopressin or Epi
• Amiodarone
• Lidocaine
• Mg
• Procainamide
• Bicarbonate

Question 28

Tx of Pulseless Electrical Activity (PEA) or Asytole (Flat line)

Answer 28

• Epinephrine

- Atropine: DOC for symptomatic bradycardia

Question 29

Treatment of symptomatic bradycardia

Answer 29

1. Atropine:
2. Dopamine:
3. Epi: