Drugs Flashcards

1
Q

what is a drug?

A

a drug is any chemical substance which when taken into the body, alters one or more physical or psychological function

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2
Q

what are psychoactive drugs?

A

drugs which interfere with the Nervous system, and cause changes in mental state and behaviour.

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3
Q

what are examples of psychoactive drugs?

A
  • cannabis
  • nicotine
  • LSD
  • Heroin
  • Alcohol
  • ecstacy
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4
Q

what is the misuse of drugs act 1971?

A

the possession and supply of certain drugs legal

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5
Q

What are the 3 classes of controlled drugs?

A
  • CLASS A, B AND C
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6
Q

CLASS A drug examples

A
  • Heroin
  • magic mushrooms
  • cocaine
  • LSD
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7
Q

CLASS B drug examples

A
  • Speed
  • Ritalin
  • Cannabis
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8
Q

CLASS C drug examples

A
  • Valium
  • Rohypinol
  • Anabolics
  • Steroids
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9
Q

why are drugs misused?

A

because of the euphoric effects

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10
Q

what is a designer drug?

A

A drug with the same properties and effects as known hallucinogen or narcotic but either an altered structure.
Therefore not subject to restrictions against illegal substances

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11
Q

what are the classifications of drugs by effects, and an example?

A
  • Tranquilizers: Temazepam
  • Stimulants: caffeine, nicotine
  • Hallucinogen: LSD
  • Depressants: Heroin, Alcohol
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12
Q

What do psychoactive drugs to?

A

act as, or interferes with neurotransmitters. E.G. ACh or Enkephaline

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13
Q

what is ACh?

A

neurotransmitter which nicotine binds to the ACh Receptors

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14
Q

what are Enkephalins?

A

inhibit the action of the neurones associated with pain, heroin binds to the encephalin receptors between sensory nerve and relay neurone

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15
Q

how does Enkephalin work?

A

pain receptors –> sensory nerve –> relay neurone –> brain

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16
Q

what does noradrenaline do?

A

Increases HR, arousal and wakefulness. Amphetamines act here

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17
Q

why are the causes of drug misuse?

A
  • taken in hazardous circumstances
  • likely to cause harm
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18
Q

what can drugs be used for?

A
  • experimental (1st time use)
  • recreational (controlled, can be regular, non-addictive)
  • dependent (addictive)
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19
Q

what are the symptoms of physical dependence?

A
  • drug is necessary for metabolism
  • continued use necessary to prevent physical withdrawal symptoms
  • the person must then continue to use the drug in order to feel normal
20
Q

what are the symptoms/ reasons for psychological dependence?

A
  • compulsion to use drug for euphoric or pain relieving effects
  • used a social prop
  • decreases stress
  • no physical; effects of withdrawal
21
Q

abstinence symptoms

A

collectively withdrawal symptoms

22
Q

describe the effects of heroin on the nervous system?

A
  • reduces pain acts as analgesic binds to receptors in synapses on post-synaptic membranes
  • inhibits neurones responsible for pain
    leading to loss of feeling
  • euphoria with use - more receptors made and so physical dependence
  • secretion of digested juices reduced -leading to loss of appetite
  • peristalsis reduced/ constipation
  • stimulates reward/ pleasure pathways
  • pathway associated with dopamine;
  • loss of consciousness;
  • Heroin is a depressant and an opiate
  • Binds to enkephalin receptors
  • Reduces activity of the NS
  • Including respiratory and cardiac centres (can be fatal)
  • Loss of consciousness
23
Q

what is drug tolerance?

A

When a person’s reaction to a drug decreases and an increased dose is required to achieve the same effect.

24
Q

Explain how drug tolerance to heroin may develop
?

A
  • Increase in the number of enkephalin receptors
  • Increased metabolism of the drug
  • Inhibits production of natural enkephalins
  • Therefore need to increase dose to achieve the same effect.
25
Explain how drug tolerance to nicotine may develop
?
- Nicotine mimics the action of acetylcholine - Binds to Ach receptors - Increase the no of ACh receptors - Smokers therefore need to smoke more cigarettes to achieve the same effect.
26
Why can alcohol become a compulsive pleasure?
it stimulates the production of enkephalins in the brain.
27
what is alcohol, how is it metabolised?
A small molecule Metabolised by the liver: Ethanol --> ethanal --> ethanoate
27
how is alcohol broken down?
Catalysed by enzymes, which will work faster in response to presence of alcohol. The alcohol is respired faster and the ethanoate can enter the Krebs Cycle.
28
draw a diagram to show the metabolism of alcohol in liver cells?
29
Outline what happens to alcohol after it has been absorbed into the blood.
Alcohol easily passes through cell membranes and is metabolised by the liver * Ethanol is converted into ethanal by the enzyme ethanol dehydrogenase Ethanal is converted into acetate by the enzyme ethanal dehydrogenase NAD is the H carrier Acetate is converted into acetyl CoA and enters the Krebs cycle Or is converted into FA’s by the smooth ER
30
Explain how the liver metabolises alcohol?
- Ethanol is converted into ethanal by the enzyme ethanol dehydrogenase - Ethanal is converted into acetate by the enzyme ethanal dehydrogenase - NAD is the H carrier - Acetate is converted into acetyl CoA and enters the Krebs cycle - Or is converted into FA’s by the smooth ER
31
What is the long term impact of alcohol on the liver?
- fatty liver - liver cells (hepatocytes) destroyed - cirrhosis/scar tissue - cancer - inflammation - hepatitis
32
what is the effect of alcohol on the brain?
alcohol quickly affects the central nervous system the behavioural effects depend on the blood alcohol content
33
how many units can the liver metabolise per hour?
8g alcohol - 1 unit
34
what is the symptoms of 1-2 units of alcohol?
- increased confidence - social restraint
35
what is the symptoms of 4-5 units of alcohol?
- impaired judgements - loss of inhibition
36
what is the symptoms of 6-7 units of alcohol?
- impaired co-ordination - slurred speech - slow reaction times
37
what is the symptoms of 8-9 units of alcohol?
- loss of voluntary activity - blurred vision - heightened emotions
38
what is the symptoms of >10 units of alcohol?
- total loss of co-ordination - surgical anaesthesia
39
what are the social consequences on family due to heavy alcohol consumption?
- domestic violence - child abuse - teenage drinking - unwanted pregnancy - unemployment - homelessness
40
what are the social consequences on crime due to heavy alcohol consumption?
- vandalism - road accidents - murder - petty crime - sexual crimes
41
what are the social consequences on costs due to heavy alcohol consumption?
- legal costs - ambulance/fire service - NHS costs - rehabilitation - revenue to gov. for sale of alcohol
42
what are the long term effects of alcohol on the CNS?
- Inhibits release of ADH – therefore - less water is reabsorbed – dehydration - Shrinkage of brain cells - Hypoxia – reduction in oxygen supply - Hypoglycaemia - Less E for nerve cells - Impaired motor control - Loss of short term memory
43
long term affects of alcohol in Peripheral Nervous system?
- Alcohol provides E, therefore often poor diet, reduced vitamins - Low Vit B1 - degeneration of sensory nerves - Related to feeling cold /pains / numbness - degeneration of motor nerves related to muscle weakness/wasting - damage to autonomic nerves related to incontinence/ impotence/ blurred vision = POLYNEUROPATHY
44
What is polyneuropathy?
simultaneous malfunction of many peripheral nerves throughout the body.