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PDA Drugs > Drugs > Flashcards

Drugs Flashcards

1
Q

Irbesartan/Acapro

A

Antihypertensive
Lowers diastolic blood pressure
Shows graded response

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2
Q

Procainamide/Pronestyl

A

Suppresses arrythmias

Show quantal response

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3
Q

Digoxin/Lanoxin

A

Cardiac glycosides
Blocks Na+/K+ ATPase for heart failure patients
Drug that blocks active trasnport system

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4
Q

Cocaine

A

blocks reuptake of dopamine at dopaminergic nerve

Blocks active transport system

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5
Q

Cyclosporin

A

Blocks drug efflux pump P-glycoprotein

Blocks active transport system

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6
Q

Colchicine

A

Gout
Binds tubulin and prevents microtuble polymerization
Effects structural proteins

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7
Q

Lithium

A

Antidepressant
Interferes with breakdown of IP
Termination of IP3 signal

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8
Q

Isoprotereronol

A

Beta agonist

Show internalization of receptors

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9
Q

Trastuzumab/Herceptin

A

Monoclonal antibody

Binds HER2 and inhibits to induce tumor regression in metastatic breast tumors

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10
Q

Ceutximab/Erbitux

Panitumumab/Vectibix

A

Monoclonal antibody
Used in metastatic colon cancer
Target EGF receptor

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11
Q

Gefitnib/Iressa

Erlotib/Tarceva

A

Tyrosine kinase inhibitors
Block ATP bind site on kinase
All for oral administration by they are less specific than antibodies

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12
Q

Curare derivatives

A

Anesthesia to cause muscle relaxation

Example of nicotinic receptor

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13
Q

CNS drugs

A

Target the ganglion for antihypertensive effect

Example of nicotinic receptor

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14
Q

Varenicline/Chantax

A

Smoking cessation
Targets CNS nicotinic receptors
Example of nicotinic receptor drug

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15
Q

Benzodiazepine agonist

A

Binds GABA-A receptor and enhance effect (sedation anziolysis

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16
Q

Benodiazepine antagonists

A

Blocks the benzodiasepine agonists

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17
Q

Benzodiasepine inverse agonist

A

Negative allosteric modulator inhibits GABA effect causing anxiety and seizures

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18
Q

Lidocaine

A

Antiarryhthmic

NA channel blocking agent

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19
Q

Amlodipine

A

antihypertensive
Ca channel antagonists
Decrease muscular tone

20
Q

Anti-diabetic
Sulfonylurea
Meglitinide

A

Block potassium channel and depolarization result in insulin secretion
Type II only

21
Q

Diazoxide/Hyperstat

A

Severe hypertension

Stimulate K channel

22
Q

Dexamethason

A

Synthetic glucocorticoid
Anti-inflammatory agent
Ligand binding domain is responsible for nuclear translocation

23
Q

Predisone

A

Glycorticoid

transplant rejection

24
Q

Spironolactone

A

Mineralocorticoid

Antagonist used in liver disease

25
Q

Tamoxifen/Nolvadex

A

Estrogen antagonist

Blocks the binding groove of the co-activator in nuclear receptor/breast cancer

26
Q

Mifepristone

A

Estrogen antagonist

Used for abortions

27
Q

Thiazolidinedione

A

Used in type II diabetes act on PPAR-gama to sensitize cell to insulin

28
Q

Ritonavir/Norvir

A

HIV Protease

29
Q

Asprin

A

Anti-inflammatory

COX inhibitor

30
Q

Penicillin

A

Antibotic

Bacterial glycopeptide

31
Q

Vinorelbine

A

Target microtubules to inhibit STAT 3 phosphorylation in breast cancer

32
Q

Curcumin

A

Pancreatic cancer

33
Q

Cyclopamide

A

Hedgehog pathway blocker

Poor pharmacokinetics and tolerability

34
Q

Vismodegib/Erivedge

A

Selective hedgehog pathway inhibitor used in advanced carcinomal/lower Gli

35
Q

Pravastin

A

Suppresses INF gamma

Decreasing STAT 1 activation

36
Q

Berbamine

A

Inhibits STAT1,4 and 6

37
Q

Pimozide

A

Neuroleptic drug

Inhibits STAT5phosporylation and suppresses STAT5 to cause apoptosis

38
Q

Drugs for STAT 3

A

ASOs, capsaicin, vinorelbine and paclitaxel

39
Q

Drugs act on GABA A Receptor

A

Barbiturates, Loreclezole, steroids, BZ and PTX

40
Q

Drugs block channel proteins

A

Local anesthetics, antipilectics

antiarrhythmic drugs

41
Q

Insulin

A

PKB, MAP kinase PI3 kinase

42
Q

cAMP

A

PKA
cAMP-dependent protein kinase
PKA/cAPK phosphorylates Ser/THr side chains

43
Q

cGMP

A

PKG

Opens cation channels in rods

44
Q

DAG

A

PKC

45
Q

IP3

A

Ca channels in ER

PDA Drugs (1 decks)

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