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Drug Monographs > Drugs > Flashcards

Drugs Flashcards

1
Q

Accrufer

ferric maltol

A

purpose: Treatment of iron deficiency anemia in adults unresponsive or intolerant to other oral iron preparations

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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2
Q

Adheroza

trastuzumab

A

purpose: Biosimilar to Herceptin

MOA:

sig:
monitoring ade:
monitoring efficacy:
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3
Q

Apretude

cabotegravir

A

purpose: Injectable antiretroviral (with optional oral lead-in) for HIV pre-exposure prophylaxis

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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4
Q

Armlupeg

pegfilgrastim

A

purpose: Biosimilar to Neulasta

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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5
Q

Ayvakyt

avapritinib

A

purpose: Tyrosine kinase inhibitor for advanced systemic mastocytosis

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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6
Q

Awiqli

insulin icodec

A

purpose: Long-acting, once-weekly insulin for adults with diabetes

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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7
Q

Cabtreo

clindamycin phosphate / adapalene / benzoyl peroxide

A

purpose: Gel for treatment of acne in patients ≥ 12 years of age

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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8
Q

Capvaxive

pneumococcal 21-valent conjugate vaccine

A

purpose: Vaccine for prevention of invasive pneumococcal disease in adults

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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9
Q

Casgevy

exagamglogene autotemcel

A

purpose: Gene-edited therapy for sickle cell disease with recurrent vaso-occlusive crises, and transfusion-dependent β-thalassemia

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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10
Q

Clorotekal

chloroprocaine hydrochloride B.

A

purpose: spinal anesthetic for surgical procedures in adults

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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11
Q

Combogesic IV

acetaminophen / ibuprofen

A

purpose: Analgesic for short-term management of pain or as an adjunct to opioid analgesics

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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12
Q

Comirnaty

COVID-19 mRNA vaccine, Omicron KP.2 variant

A

purpose: Vaccine for active immunization against COVID-19

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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13
Q

Ebglyss

lebrikizumab

A

purpose: Interleukin inhibitor monoclonal antibody for moderate-to-severe atopic dermatitis

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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14
Q

Eylea HD

aflibercept

A

purpose: New higher-strength (8 mg/0.07 mL) solution (compared to Eylea)

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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15
Q

Ferinject

ferric carboxymaltose

A

purpose: Treatment of iron deficiency anemia

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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16
Q

Fruzaqla

fruquintinib

A

purpose: Tyrosine kinase inhibitor for treatment of metastatic colorectal cancer

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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17
Q

Fruzaqla

fruquintinib

A

purpose: Tyrosine kinase inhibitor for treatment of metastatic colorectal cancer

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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18
Q

Imdelltra

tarlatamab

A

purpose: T-cell engager for extensive stage small cell lung cancer

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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19
Q

Ixchiq

chikungunya vaccine

A

purpose: Live, attenuated vaccine for prevention of disease caused by chikungunya virus in adults

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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20
Q

Jubbonti

denosumab

A

purpose: Biosimilar to Prolia

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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21
Q

Miebo

perfluorohexyloctane

A

purpose: Solution for treatment of dry eye disease

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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22
Q

Mounjaro KwikPen

tirzepatide injection

A

purpose: New multidose prefilled pen in various strengths

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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23
Q

Myalepta

metreleptin

A

purpose: Recombinant human leptin analog for treating complications of leptin deficiency in lipodystrophy

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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24
Q

Niopeg

pegfilgrastim

A

purpose: Biosimilar to Neulasta

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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25
Q

Nordimet

methotrexate

A

purpose: Single-use prefilled pens in various strengths for rheumatoid arthritis and psoriasis/psoriatic arthritis

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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26
Q

Nuvaxovid

COVID-19 vaccine, recombinant protein, adjuvanted, Omicron JN.1 variant

A

purpose: Vaccine for active immunization against COVID-19

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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27
Q

Olumiant

baricitinib

A

purpose: New 4 mg tablet for treatment of adults with severe alopecia areata

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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28
Q

Okedi

risperidone

A

purpose: Extended-release injectable suspension with two-syringe mixing system, given every 4 weeks

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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29
Q

Opzelura

ruxolitinib

A

purpose: JAK inhibitor cream for nonsegmental vitiligo, and mild to moderate atopic dermatitis

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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30
Q

Plenvu

polyethylene glycol 3350 / sodium ascorbate / sodium sulfate anhydrous / ascorbic acid / sodium chloride / potassium chloride

A

purpose: Powder for oral solution; an osmotic laxative colonoscopy preparation solution for adults

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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31
Q

Pyzchiva / Pyzchiva I.V

ustekinumab

A

purpose: Biosimilar to Stelara / Stelara I.V.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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32
Q

Rybelsus

semaglutide, optimized formulation

A

purpose: New tablet formulation with an absorption enhancer (1.5 mg, 4 mg and 9 mg strengths)

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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33
Q

Spikevax

COVID-19 mRNA vaccine, Omicron KP.2 variant

A

purpose: Active immunization against COVID-19

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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34
Q

Steqeyma / Steqeyma I.V

ustekinumab

A

purpose: Biosimilar to Stelara / Stelara I.V.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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35
Q

Talvey

talquetamab

A

purpose: Antineoplastic monoclonal antibody for relapsed or refractory multiple myeloma

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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36
Q

Tecentriq SC

atezolizumab

A

purpose: New SC format for patients who wish to transition from an IV to SC dosage form

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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37
Q

Tibsovo

ivosidenib

A

purpose: Mutant IDH1 enzyme inhibitor for acute myeloid leukemia or metastatic cholangiocarcinoma

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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38
Q

Truqap

capivasertib

A

purpose: AKT (serine/threonine kinase) inhibitor for HR+, HER2-negative locally advanced or metastatic breast cancer

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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39
Q

Tyenne

tocilizumab

A

purpose: A biosimilar to Actemra

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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40
Q

Velsipity

etrasimod

A

purpose: Sphingosine 1-phosphate receptor modulator for adults with moderately to severely active ulcerative colitis

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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41
Q

Voranigo

vorasidenib

A

purpose: IDH1 / IDH2 enzyme inhibitor for Grade 2a astrocytoma or oligodendroglioma

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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42
Q

Voydeya

danicopan

A

purpose: Complement inhibitor; add-on therapy in paroxysmal nocturnal hemoglobinuria

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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43
Q

Wainua

eplontersen

A

purpose: Antisense oligonucleotide for hereditary transthyretin-mediated amyloidosis

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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44
Q

Winrevair

sotatercept

A

purpose: Activin signalling inhibitor for treatment of pulmonary arterial hypertension

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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45
Q

Wyost

denosumab

A

purpose: Biosimilar to Xgeva

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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46
Q

Xenpozyme

olipudase alfa

A

purpose: Enzyme replacement therapy for long-term treatment of non-CNS manifestations of acid sphingomyelinase deficiency

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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47
Q

Zilbrysq

zilucoplan

A

purpose: Complement C5 inhibitor for generalized myasthenia gravis

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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48
Q

Ayvakyt

avapritinib

A

purpose: for advanced systemic mastocytosis

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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49
Q

Casgevy

exagamglogene autotemcel

A

purpose: a gene-edited therapy for sickle cell disease and transfusion-dependent β-thalassemia

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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50
Q

Opzelura

ruxolitinib

A

purpose: a topical JAK inhibitor cream for vitiligo and mild/moderate atopic dermatitis

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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51
Q

Rybelsus

semaglutide

A

purpose: optimized formulation with an absorption enhancer

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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52
Q

Tyenne

tocilizumab

A

purpose: a biosimilar to Actemra

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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53
Q

Uplizna

Inebilizumab

A

purpose: Neuromyelitis optica spectrum disorder

MOA: Immunosuppressants

sig:
monitoring ade:
monitoring efficacy:
interactions:

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54
Q

Velsipity

Etrasimod

A

purpose: Ulcerative colitis

MOA: L04 Immunosuppressants

sig:
monitoring ade:
monitoring efficacy:
interactions:

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55
Q

Sibboran.

Landiolol hydrochloride

A

purpose: short-term reduction of ventricular rate in patients with supraventricular tachycardia including atrial fibrillation and atrial flutter in perioperative, postoperative, or other acute circumstances.

MOA: Beta blocking agents

sig:
monitoring ade:
monitoring efficacy:
interactions:

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56
Q

Xenpozyme

Olipudase alfa

A

purpose: Acid sphingomyelinase deficiency (historically known as Niemann-Pick disease)

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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57
Q

Ferinject.

ferric carboxymaltose

A

purpose: the treatment of iron deficiency anemia (IDA) in adult and pediatric patients 1 year of age and older when oral iron preparations are not tolerated or are ineffective.

the treatment of iron deficiency (ID) in adult patients with heart failure and New York Heart Association (NYHA) class II/III to improve exercise capacity

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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58
Q

Beqvez.

Fidanacogene elaparvovec

A

purpose: moderately severe to severe hemophilia B (congenital Factor IX [FIX] deficiency)

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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59
Q

Arexvy.

Respiratory syncytial virus prefusion F protein (RSVPreF3)

A

purpose: prevention of lower respiratory tract disease (LRTD) caused by respiratory syncytial virus (RSV) in adults 60 years of age and older.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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60
Q

Comirnaty Omicron XBB.1.5.

Raxtozinameran

A

purpose: active immunization against coronavirus disease 2019 (COVID‑19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) in individuals 6 months of age and older.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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61
Q

Livmarli.

Maralixibat (supplied as maralixibat chloride)

A

purpose: cholestatic pruritus in patients with Alagille syndrome (ALGS)

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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62
Q

Ondexxya

Andexanet alfa

A

purpose: rapid reversal of anticoagulation due to life‑threatening or uncontrolled bleeding related to rivaroxaban or apixaban

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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63
Q

Sogroya

Somapacitan

A

purpose: the long-term treatment of pediatric patients who have growth failure due to an inadequate secretion of endogenous growth hormone (growth hormone deficiency).

the replacement of endogenous growth hormone in adults with growth hormone deficiency.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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64
Q

Spikevax XBB.1.5

Andusomeran

A

purpose: active immunization against coronavirus disease 2019 (COVID‑19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) virus in individuals 6 months of age and older

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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65
Q

Imcivree

Setmelanotide

A

purpose: Bardet-Biedl syndrome (BBS), or

Genetically confirmed biallelic pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency due to variants interpreted as pathogenic, likely pathogenic, or of uncertain significance.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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66
Q

Omvoh

Mirikizumab

A

purpose: Ulcerative colitis is a chronic inflammatory disease of the rectum and colon

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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67
Q

Prehevbrio.

Hepatitis B Surface Antigen

A

purpose: active immunization against infection caused by all known subtypes of hepatitis B virus in adults 18 years of age and older

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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68
Q

Verquvo.

Vericiguat

A

purpose: symptomatic chronic heart failure in adult patients with reduced ejection fraction who are stabilized after a recent heart failure decompensation event requiring hospitalization and/or intravenous diuretic therapy

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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69
Q

Xcopri.

Cenobamate

A

purpose: adjunctive therapy in the management of partial-onset seizures in adults with epilepsy who are not satisfactorily controlled with conventional therapy

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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70
Q

Onakta.

Tirbanibulin

A

purpose: non-hyperkeratotic, non-hypertrophic actinic keratosis (Olsen grade 1) on the face or scalp in adults.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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71
Q

Quviviq.

Daridorexant

A

purpose: insomnia, characterized by difficulties with sleep onset and/or sleep maintenance

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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72
Q

Winlevi.

Clascoterone

A

purpose: acne vulgaris in patients 12 years of age and older

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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73
Q

Beyfortus.

Nirsevimab

A

purpose:
Neonates and infants during their first RSV season.

Children up to 24 months of age who remain vulnerable to severe RSV disease through their second RSV season, which may include but is not limited to children with:

Chronic lung disease of prematurity (CLD)

Hemodynamically significant congenital heart disease (CHD)

Immunocompromised states

Down syndrome

Cystic fibrosis

Neuromuscular disease

Congenital airway anomalies.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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74
Q

Locametz.

Kit for the preparation of gallium (68Ga) gozetotide solution for injection

A

purpose:
radioactive diagnostic agent indicated for positron emission tomography (PET) of prostate-specific membrane antigen (PSMA)-positive lesions in men with prostate cancer:

with suspected metastasis who are candidates for initial definitive therapy.

with suspected recurrence based on elevated serum prostate-specific antigen (PSA) level.

for identification of patients with progressive metastatic castration-resistant prostate cancer (mCRPC), for whom PSMA-targeted therapy is indicated.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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75
Q

Spevigo.

Spesolimab

A

purpose: flares in adult patients with generalized pustular psoriasis (GPP)

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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76
Q

Qulipta.

Atogepant

A

purpose: prevention of episodic migraine (<15 migraine days per month) in adults

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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77
Q

Alhemo.

Concizumab

A

purpose: adolescent and adult patients (12 years of age or older) with hemophilia B (congenital factor IX [FIX] deficiency) who have FIX inhibitors and require routine prophylaxis to prevent or reduce the frequency of bleeding episodes

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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78
Q

Carvykti.

Ciltacabtagene autoleucel

A

purpose: adult patients with multiple myeloma, who have received at least three prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 antibody, and who are refractory to their last treatment

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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79
Q

Columvi.

Glofitamab

A

purpose: adult patients with relapsed or refractory diffuse large B-cell lymphoma, not otherwise specified, diffuse large B-cell lymphoma arising from follicular lymphoma, or primary mediastinal B-cell lymphoma, who have received two or more lines of systemic therapy and are ineligible to receive or cannot receive CAR T-cell therapy or have previously received CAR T-cell therapy

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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80
Q

Vegzelma.

Bevacizumab

A

purpose: metastatic colorectal cancer; locally advanced, metastatic, or recurrent non-small cell lung cancer (NSCLC); platinum-sensitive recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer; platinum-resistant recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer; and malignant glioma (World Health Organization grade IV) - glioblastoma.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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81
Q

Empaveli.

Pegcetacoplan

A

purpose: adult patients with paroxysmal nocturnal hemoglobinuria (PNH) who have an inadequate response to, or are intolerant of, a complement component 5 (C5) inhibitor

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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82
Q

Camzyos.

Mavacamten

A

purpose: symptomatic obstructive hypertrophic cardiomyopathy of New York Heart Association (NYHA) Class II-III in adult patients

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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83
Q

Mounjaro.

Tirzepatide

A

purpose:
Once-weekly administration as an adjunct to diet and exercise to improve glycemic control for the treatment of adult patients with type 2 diabetes mellitus (T2DM).

As monotherapy when metformin is inappropriate due to contraindication or intolerance.
In combination with:
metformin, or
metformin and a sulfonylurea, or
metformin and a sodium-glucose cotransporter 2 inhibitor (SGLT2i), or
basal insulin with or without metformin.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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84
Q

Kengrexal.

Cangrelor

A

purpose: reducing the risk of thrombotic cardiovascular events (periprocedural myocardial infarction [MI], repeat coronary revascularization, and stent thrombosis [ST]) in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI) who have not been treated with an oral P2Y12 platelet inhibitor and are not being given a glycoprotein IIb/IIIa inhibitor

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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85
Q

Sunlenca.

Lenacapavir

A

purpose: Treatment of human immunodeficiency virus type 1 (HIV-1) infection in heavily treatment‑experienced adults with multidrug resistant (MDR) HIV-1 infection failing their current antiretroviral regimen due to resistance, intolerance, or safety considerations

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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86
Q

Ubrelvy.

Ubrogepant

A

purpose: acute treatment of migraine with or without aura in adults.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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87
Q

Elonox/Elonox HP.

Enoxaparin sodium

A

purpose: prevention of venous thromboembolic disease, treatment of deep vein thrombosis, treatment of unstable angina and non-Q-wave myocardial infarction concurrently with acetylsalicylic acid, and treatment of acute ST-segment elevation myocardial infarction.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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88
Q

Ervebo.

Ebola Zaire Vaccine (rVSVΔG-ZEBOV-GP, live)

A

purpose: active immunization of individuals 18 years of age or older to protect against Ebola Virus Disease (EVD) caused by Zaire Ebola virus (ZEBOV).

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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89
Q

Sotyktu.

Deucravacitinib

A

purpose: adult patients with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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90
Q

Sunlenca.

Lenacapavir

A

purpose: treatment of human immunodeficiency virus type 1 (HIV-1) infection in heavily treatment‑experienced adults with multidrug resistant (MDR) HIV-1 infection failing their current antiretroviral regimen due to resistance, intolerance, or safety considerations

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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91
Q

Illuccix.

Kit for the preparation of gallium (68Ga) gozetotide for intravenous injection

A

purpose: positron emission tomography (PET) of prostate-specific membrane antigen (PSMA)-positive lesions in men with prostate cancer:

with suspected metastasis who are suitable for initial definitive therapy.
with suspected recurrence with elevated serum prostate-specific antigen (PSA) level.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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92
Q

Kerendia.

Finerenone

A

purpose: adjunct to standard of care therapy in adults with chronic kidney disease (CKD) and type 2 diabetes (T2D) to reduce the risk of:

end-stage kidney disease and a sustained decrease in estimated glomerular filtration rate,
cardiovascular death, non‑fatal myocardial infarction and hospitalization for heart failure.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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93
Q

Livtencity.

Maribavir

A

purpose: adults with post-transplant cytomegalovirus (CMV) infection/disease who are refractory (with or without genotypic resistance) to one or more prior antiviral therapies.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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94
Q

Rymti.

Etanercept

A

purpose: Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, and plaque psoriasis in adult and pediatric patients.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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95
Q

Cibinqo.

Abrocitinib

A

purpose: patients 12 years and older with refractory moderate to severe atopic dermatitis, including the relief of pruritus, who have had an inadequate response to other systemic drugs (e.g., steroid or biologic), or for whom these treatments are not advisable

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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96
Q

Myxredlin.

Insulin (human)

A

purpose: patients with diabetes mellitus who require insulin by intravenous administration for the control of hyperglycemia.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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97
Q

Pluvicto.

Lutetium (177Lu) vipivotide tetraxetan

A

purpose: adult patients with prostate‑specific membrane antigen (PSMA)‑positive metastatic castration-resistant prostate cancer (mCRPC) who have received at least one androgen receptor pathway inhibitor (ARPI) and taxane‑based chemotherapy

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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98
Q

Welireg.

Belzutifan

A

purpose: adult patients with von Hippel-Lindau (VHL) disease who require therapy for associated non-metastatic renal cell carcinoma (RCC), not requiring immediate surgery. Efficacy in patients with VHL disease-associated RCC was based on objective response rate and duration of response in a single-arm study

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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99
Q

Tezspire.

Tezepelumab

A

purpose: adults and adolescents aged 12 years and older with severe asthma

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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100
Q

Albrioza.

Sodium phenylbutyrate and ursodoxicoltaurine

A

purpose: patients with amyotrophic lateral sclerosis (ALS)

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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101
Q

Korsuva.

Difelikefalin (supplied as difelikefalin acetate)

A

purpose: moderate to severe pruritus associated with chronic kidney disease in adult patients on hemodialysis (HD)

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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102
Q

Koselugo.

Selumetinib (supplied as selumetinib sulfate)

A

purpose: pediatric patients aged 2 years and above with neurofibromatosis type 1 who have symptomatic, inoperable plexiform neurofibromas

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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103
Q

Orladeyo.

Berotralstat (supplied as berotralstat hydrochloride)

A

purpose: routine prevention of attacks of hereditary angioedema (HAE) in adults and pediatric patients 12 years of age and older.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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104
Q

Poteligeo.

Mogamulizumab

A

purpose: adult patients with relapsed or refractory mycosis fungoides or Sézary syndrome after at least one prior systemic therapy

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

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105
Q

Xpovio.

Selinexor

A

purpose: adult patients with multiple myeloma who have received at least one prior therapy.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

106
Q

Bimzelx.

Bimekizumab

A

purpose: moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

107
Q

Kimmtrak.

Tebentafusp

A

purpose: human leukocyte antigen (HLA)-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

108
Q

Scemblix.

Asciminib (supplied as asciminib hydrochloride)

A

purpose: adult patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP) previously treated with two or more tyrosine kinase inhibitors.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

109
Q

Breyanzi.

Lisocabtagene maraleucel

A

purpose: adult patients with relapsed or refractory (R/R) large B-cell lymphoma after two or more lines of systemic therapy, including: diffuse large B-cell lymphoma (DLBCL) not otherwise specified; primary mediastinal large B-cell lymphoma (PMBCL); high grade B-cell lymphoma; and DLBCL arising from follicular lymphoma.
MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

110
Q

Byooviz.

Ranibizumab

A

purpose: neovascular (wet) age-related macular degeneration;
visual impairment due to diabetic macular edema;
visual impairment due to macular edema secondary to retinal vein occlusion;
visual impairment due to choroidal neovascularization secondary to pathologic myopia;
visual impairment due to choroidal neovascularization secondary to ocular conditions other than age-related macular degeneration or pathologic myopia, including but not limited to angioid streaks, post- inflammatory retinochoroidopathy, central serous chorioretinopathy or idiopathic chorioretinopathy.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

111
Q

Prevnar 20.

Pneumococcal 20-valent conjugate vaccine (diphtheria cross-reactive material 197 [CRM197] protein)

A

purpose: prevention of pneumonia and invasive pneumococcal disease (including sepsis, meningitis, bacteremic pneumonia, pleural empyema and bacteremia) caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in adults 18 years of age and older.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

112
Q

Semglee.

Insulin glargine

A

purpose: for once-daily subcutaneous administration in the treatment of patients over 17 years of age with Type 1 (T1DM) or Type 2 (T2DM) diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia.
in the treatment of pediatric patients (over 6 years old) with Type 1 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

113
Q

Vabysmo.

Faricimab

A

purpose: neovascular (wet) age-related macular degeneration (AMD) and diabetic macular edema (DME)

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

114
Q

Tabrecta.

Capmatinib

A

purpose: adult patients with locally advanced unresectable or metastatic non‑small cell lung cancer (NSCLC) harbouring mesenchymal‑epithelial transition (MET) exon 14 (METex14) skipping alterations

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

115
Q

Vraylar.

Cariprazine

A

purpose: Schizophrenia

Vraylar (cariprazine) is indicated for:

the treatment of schizophrenia in adults.

Bipolar I disorder

Bipolar Mania: acute management of manic or mixed episodes associated with bipolar I disorder in adults, and
Bipolar Depression: acute management of depressive episodes associated with bipolar I disorder in adults.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

116
Q

Tavneos.

Avacopan

A

purpose: adjunctive treatment of adult patients with severe active anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (granulomatosis with polyangiitis [GPA] and microscopic polyangiitis [MPA]) in combination with standard background therapy including glucocorticoids

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

117
Q

Palynziq.

Pegvaliase

A

purpose: reduction of blood phenylalanine concentrations in patients with phenylketonuria (PKU) aged 16 years and older who blood phenylalanine levels greater than 600 micromol/L

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

118
Q

Rholistiq.

Belumosudil

A

purpose: adult and pediatric patients 12 years and older with chronic graft-versus-host disease (GVHD) after failure of at least two prior lines of systemic therapy

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

119
Q

Rybrevant.

Amivantamab

A

purpose: adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) exon 20 insertion mutations whose disease has progressed on or after platinum-based chemotherapy.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

120
Q

Evusheld.

Tixagevimab and Cilgavimab

A

purpose: pre-exposure prophylaxis of coronavirus disease 2019 (COVID-19) in adults and adolescents (12 years of age and older weighing at least 40 kg), who have not had a known recent exposure to an individual infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and:

who are immune compromised and unlikely to mount an adequate immune response to COVID-19 vaccination; or
for whom COVID-19 vaccination is not recommended.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

121
Q

HyQvia.

Normal immunoglobulin (human) and recombinant human hyaluronidase

A

purpose: replacement therapy for primary humoral immunodeficiency and secondary humoral immunodeficiency in adult patients.

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

122
Q

Ontruzant.

Trastuzumab

A

purpose: human epidermal growth factor receptor 2 (HER2)-positive early breast cancer, metastatic breast cancer, and metastatic gastric cancer

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

123
Q

Oxlumo.

Lumasiran

A

purpose: primary hyperoxaluria type 1 (PH1) to lower urinary oxalate levels in pediatric and adult patients

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

124
Q

Rholistiq.

Belumosudil

A

purpose: adult and pediatric patients 12 years and older with chronic graft-versus-host disease (GVHD) after failure of at least two prior lines of systemic therapy

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

125
Q

Rybrevant.

Amivantamab

A

purpose: adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) exon 20 insertion mutations whose disease has progressed on or after platinum-based chemotherapy

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

126
Q

Sohonos.

Palovarotene

A

purpose: reduction of the formation of heterotopic ossification in adults and children aged 8 years and above for females and 10 years and above for males with fibrodysplasia (myositis) ossificans progressiva

MOA:

sig:
monitoring ade:
monitoring efficacy:
interactions:

127
Q
A

purpose:

MOA:

sig:
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monitoring efficacy:
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128
Q
A

purpose:

MOA:

sig:
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129
Q
A

purpose:

MOA:

sig:
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130
Q
A

purpose:

MOA:

sig:
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131
Q
A

purpose:

MOA:

sig:
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monitoring efficacy:
interactions:

132
Q
A

purpose:

MOA:

sig:
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132
Q
A

purpose:

MOA:

sig:
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133
Q
A

purpose:

MOA:

sig:
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133
Q
A

purpose:

MOA:

sig:
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134
Q
A

purpose:

MOA:

sig:
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135
Q
A

purpose:

MOA:

sig:
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136
Q
A

purpose:

MOA:

sig:
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137
Q
A

purpose:

MOA:

sig:
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138
Q
A

purpose:

MOA:

sig:
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139
Q
A

purpose:

MOA:

sig:
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140
Q
A

purpose:

MOA:

sig:
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141
Q
A

purpose:

MOA:

sig:
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141
Q
A

purpose:

MOA:

sig:
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142
Q
A

purpose:

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sig:
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142
Q
A

purpose:

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143
Q
A

purpose:

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144
Q
A

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145
Q
A

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145
Q
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145
Q
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146
Q
A

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147
Q
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148
Q
A

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149
Q
A

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150
Q
A

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151
Q
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152
Q
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153
Q
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154
Q
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155
Q
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156
Q
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157
Q
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158
Q
A

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159
Q
A

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160
Q
A

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161
Q
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162
Q
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163
Q
A

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164
Q
A

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165
Q
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166
Q
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167
Q
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168
Q
A

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169
Q
A

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170
Q
A

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171
Q
A

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172
Q
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173
Q
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174
Q
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175
Q
A

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176
Q
A

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Drug Monographs (3 decks)

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