Drugs

Question 1

metoclopramide

Answer 1

D2 receptor antagonist
- uses: mainly nausea, GORD, gastroparesis, combined with analgesia
- ❌: acute dystonia, diarrhoea, hyperprolactinaemia, parkinsonism
- ⚠️: bowel obstruction, young adults + children due to risk of oculogyric crisis

Question 2

what are the actions of metoclopramide

Answer 2

• dopamine antagosnist
• agonist effect on peripheral 5HT3
• antagonistic effect on muscarinic receptors to promote gastric emptying

Question 3

what are absolute contraindications of lap surgery

Answer 3

• haemodynamic instability
• raised ICP
• acute intestinal obstrucion
• uncorrected coagulopathy

Question 4

what monoclonal antibody is prescribed in C.diff infections and why

Answer 4

bezlotoxumab - binds to toxin B of bacterium