Drugs Flashcards
MOA of adrenaline: alpha 1
Stimulates smooth muscle contractions, vasoconstriction & stimulates BGL
MOA of adrenaline: beta 1
Increase cardiac contractility, increase in HR, increase in speed of electrical conduction
MOA of adrenaline: Beta 2
Skeletal muscle vasodilation, bronchodilation, reduced histamine release
Indication for adrenaline
Anaphylaxis, severe asthma, stridor, epistaxis, trauma
MOA of GTN: GTN effect of preload
Reduces Venus return (preload) which reduces ventricular filling & CA output which reduces 02 demand
MOA of GTN: GTN effect of afterload
Causes Arterial dilation which reduces peripheral resistance (afterload). Makes it easier for L ventriculs to eject blood= decreasing O2 demand
Indication for GTN
MI, CPO, autonomic dysflexsia, Control of hypertension, STEMI
MOA of ipratropium
Antagonises (Blocks) acetylcholine receptors, causing vagel inhibition which results in bronchodilation
Indication for ipratropium
Bronchospasm: asthma or COPD or airway/smoke burns
MOA of salbutamol
Stimulates beta 2 receptors= decreases the calcium concentration within the cells and results in smooth muscle relaxation and bronchodilation
Indication for salbutamol
Bronchospasm: asthma or COPD or smoke/airway burns
Release syndrome
Known or suspected hyperkalaemia with ECG changes
MOA of prednisone/prednisolene
Corticosteroids with anti-inflammatory & immune suppressant actions= inhibits the production of prostaglandins & leukocytes & immune response
Indication for prednisone
Bronchospasm: asthma or COPD
Croup, rash, minor allergy with rash
MOA of loratadine
Blocks peripheral histamine receptors=antihistamine
Indication for Loratadine
Minor allergic reaction confined to skin
Or prominent itch associated with anaphylaxis with all other symptoms resolved
MOA of tramadol
Multiple actions: stimulates opiate receptors
Inhibits the reup take of noreadrenaline & seratoin=inhibit pain transmission in the spinal cord
Indication of tramadol
Moderate to severe pain
Especially if not giving opiates
MOA of glucagon
Stimulates glycogenolysis within the liver= the breakdown of glycogen into glucose
Indication for glucagon
Hypoglycaemia when pt can’t shallow
