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PSA > DRUGS > Flashcards

DRUGS Flashcards

1
Q

5 ALPHA REDUCTASE INHIBITORS
give some examples

A

finasteride
dutasteride

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2
Q

5 ALPHA REDUCTASE INHIBITORS
what are the indications?

A
  1. UTI symptoms in men with BPH
  2. male pattern baldness
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3
Q

5 ALPHA REDUCTASE INHIBITORS
what is the mechanism of action?

A

reduces prostate size by reducing dihydrotestosterone levels

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4
Q

5 ALPHA REDUCTASE INHIBITORS
what are some important adverse effects?

A
  • impotence
  • reduced libido
  • gynaecomastia and breast tenderness
  • hair growth
  • breast cancer
  • suicidal thoughts
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5
Q

5 ALPHA REDUCTASE INHIBITORS
what are some specific warnings with the medications?

A
  • women of childbearing age should not be exposed due to abnormal development of external genitalia in male foetus
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6
Q

5 ALPHA REDUCTASE INHIBITORS
what is the normal prescribed dose?

A
  • for BPH:
    - dutasteride 500 micrograms daily
    - finasteride 5mg daily
  • male pattern baldness:
    - finasteride 1mg daily
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7
Q

5 ALPHA REDUCTASE INHIBITORS
what information is important to convey to the patient?

A
  • it can take up to 6 months for symptoms to improve
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8
Q

5 ALPHA REDUCTASE INHIBITORS
what is the monitoring?

A

review in 3-6 months

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9
Q

ACETYLCHOLINERSTERASE INHIBITORS
what are the indications?

A
  1. mild to moderate alzheimers
  2. mild to moderate dementia in parkinsons
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10
Q

ACETYLCHOLINERSTERASE INHIBITORS
give some examples

A

donepezil
rivastigmine

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11
Q

ACETYLCHOLINERSTERASE INHIBITORS
what is the mechanism of action?

A

increasing availability of acetylcholine improves cognitive function

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12
Q

ACETYLCHOLINERSTERASE INHIBITORS
what are some important adverse effects?

A

GI upset
bronchospasm in asthma or COPD
peptic ulcers
bleeding
bradycardia and heart block
hallucinations
extrapyramidal symptoms
neuroleptic malignant syndrome

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13
Q

ACETYLCHOLINERSTERASE INHIBITORS
what are some warnings with this medication?

A

used in caution in people with asthma, COPD and those at risk of developing peptic ulcers

avoided in people with heart block and sick sinus syndrome

rivastigmine can worsen tremor in parkinsons

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14
Q

ACETYLCHOLINERSTERASE INHIBITORS
what are some important interactions?

A

NSAIDs and corticosteroids (increase risk of peptic ulcers)

antipsychotics (increase risk of neuroleptic malignant syndrome)

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15
Q

ACETYLCHOLINERSTERASE INHIBITORS
what are the prescribing doses?

A

should only be initiated by expert
donepezil 5mg daily
rivastigmine 1.5mg BD

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16
Q
A

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