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Reproductive > Drugs > Flashcards

Drugs Flashcards

1
Q

GNRH agonist names

A

Leuprolide
Gosrelin
Nafrelin

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2
Q

Moa of GNRH analogues

A

Pulsatile use increase fsh and lh
Continuous use desensitize the receptor which causes decrease lh and fsh

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3
Q

Side effects of gnrh analogues

A

Hypogonadism and decreased libido

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4
Q

Moa of desgrelix

A

Gnrh antagonist

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5
Q

Use of desgrelix

A

Used in prostate cancer

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6
Q

Name some SERMS

A

Clomiphene
Tamoxifen
Raloxifen

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7
Q

Moa of clomiphene

A

Modulates the estrogen receptor in the pituitary and inhibits the negative feedback mechanism of estrogen leading to increased fsh and lh release

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8
Q

Clomiphene used in

A

PCOS to cause ovulation

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9
Q

Side effects of clomiphene

A

Ovarian enlargement
Hot flashes
Multiple simultaneous pregnancy

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10
Q

Moa of tamoxifen

A

Antagonist of estrogen receptor in breast but agonist in uterus and bone

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11
Q

Side effect of tamoxifen

A

Increased thromboembolic events
Endometrial cancer

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12
Q

Use of tamoxifen

A

Used in ER And PR positive breast cancer
Used to prevent gynamecomastia in men undergoing prostate removal

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13
Q

Moa of raloxifen

A

Antagonist to breast and uterus and agonist to bone

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14
Q

Use of raloxifen

A

Used in osteoporosis

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15
Q

Name some aromatase inhibitors

A

Letrozole
Anastrozole
Exemastane

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16
Q

Moa of aromatase inhibitors

A

Inhibit aromatase and prevent the peripheral conversion of androgens to estrogen

17
Q

Use of aromatase inhibitors

A

ER positive breast cancer in post menopausal females

18
Q

Most effective form of contraception is

A

IUD

19
Q

In whom do we not give OCPs

A

Women more than 35 years of age who smoke
Women with cardiovascular issues
Those with migraines
Breast cancer
Liver cancer

20
Q

Danzol MOA

A

Partial agonist of androgen receptor

21
Q

Uses of danzol

A

Endometriosis and hereditary angioedema

22
Q

Side effects of danzol

A

Weight gain edema acne hirsutism

23
Q

Moa of testosterone

A

Agonist at androgen receptor

24
Q

Used in

A

Hypogonadism
Evolve secondary sexual characters

25
Q

Side effects

A

Testicular atrophy
Virilization in females
Closure of epiphyseal plates
Decrease HDL and increase LDL

26
Q

Moa of tamsulosin

A

Used in BPH decrease tone of smooth muscle help in increased urine flow

27
Q

Minoxidil MOA

A

Direct arteriolar vasodilator

28
Q

Uses of minoxidil

A

Androgenic alopecia
Malignant hypertension

Reproductive (4 decks)

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