Drugs Flashcards
GNRH agonist names
Leuprolide
Gosrelin
Nafrelin
Moa of GNRH analogues
Pulsatile use increase fsh and lh
Continuous use desensitize the receptor which causes decrease lh and fsh
Side effects of gnrh analogues
Hypogonadism and decreased libido
Moa of desgrelix
Gnrh antagonist
Use of desgrelix
Used in prostate cancer
Name some SERMS
Clomiphene
Tamoxifen
Raloxifen
Moa of clomiphene
Modulates the estrogen receptor in the pituitary and inhibits the negative feedback mechanism of estrogen leading to increased fsh and lh release
Clomiphene used in
PCOS to cause ovulation
Side effects of clomiphene
Ovarian enlargement
Hot flashes
Multiple simultaneous pregnancy
Moa of tamoxifen
Antagonist of estrogen receptor in breast but agonist in uterus and bone
Side effect of tamoxifen
Increased thromboembolic events
Endometrial cancer
Use of tamoxifen
Used in ER And PR positive breast cancer
Used to prevent gynamecomastia in men undergoing prostate removal
Moa of raloxifen
Antagonist to breast and uterus and agonist to bone
Use of raloxifen
Used in osteoporosis
Name some aromatase inhibitors
Letrozole
Anastrozole
Exemastane
Moa of aromatase inhibitors
Inhibit aromatase and prevent the peripheral conversion of androgens to estrogen
Use of aromatase inhibitors
ER positive breast cancer in post menopausal females
Most effective form of contraception is
IUD
In whom do we not give OCPs
Women more than 35 years of age who smoke
Women with cardiovascular issues
Those with migraines
Breast cancer
Liver cancer
Danzol MOA
Partial agonist of androgen receptor
Uses of danzol
Endometriosis and hereditary angioedema
Side effects of danzol
Weight gain edema acne hirsutism
Moa of testosterone
Agonist at androgen receptor
Used in
Hypogonadism
Evolve secondary sexual characters
