drugs Flashcards by Elizabeth Malik | Brainscape

Q

Cyclosporine

A

CYP3A immuno-suppressant. Stops T-cells from growing

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Felodipine

A

CYP3A Calcium-channel blocker

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Grapefruit juice

A

CYP3A inhibitor

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Ketoconazole

A

CYP3A inhibitor, Azole antifungal agent

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Rifampin

A

CYP3A Inducer, a Rifamycin

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Amitriptyline

A

CYP2D6 tricyclic antidepressant

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Clomipramine

A

CYP2D6 tricyclic antidepressant

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Desipramine

A

CYP2D6 tricyclic antidepressant

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Imipramine

A

CYP2D6 tricyclic antidepressant

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Nortryptyline

A

CYP2D6 tricyclic antidepressant

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Codeine

A

CYP2D6 opioid, can be converted to morphine

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Quinidine

A

CYP2D6 Inhibitor

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

CYP2D6

A

CYP sub-family that usually activates drugs

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Fluoxetine

A

CYP2D6 inhibitor

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Paroxetine

A

CYP2D6 inhibitor

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Warfarin

A

aka Coumadin, CYP2C19 substrate, anti-coagulant. Inhibits VKORC1 from reducing Vit K

Q

Isoniazid

A

N-acetyltransferase (NAT) enzyme, used to treat TB

Q

6-mercaptopurine

A

Destabilizes thiopurine methyltransferase (TMPT) to treat ALL (leukemia) or IBD

Q

6-thioguanine

A

Destabilizes thiopurine methyltransferase (TMPT) to treat ALL (leukemia) or IBD

Q

Sulfonamide

A

treats G6PD deficient patients

Q

Dapsone

A

treats G6PD deficient patients

Q

Azanthioprine

A

Thioprine methytransferase inhibitor, ALL (leukemia) cure by myelosuppression

Q

Imiglucerase

A

aka Cerazyme. Gaucher disease drug that is β-glucocerebrosidase analog

Q

Velaglucerase (VPRIV)

A

Gaucher disease drug that is hydrolytic lysosomal glucocerebrosidase

Q

Taliglucerase alfa

A

Gaucher disease drug that is hydrolytic lysosomal glucocerebrosidase from carrots

Q

Miglustat

A

aka Zavesca Gaucher disease drug that inhibits glucosylceramide synthase (substrate reduct. therapy)

Q

Gleevec

A

tyrosine kinase inhibitor to treat CML (leukemia)