Drugs Flashcards
Vorinostat
inhibits HCAD
Gleevec
Bcr-abl tyrosine kinase inhibitor
Chronic myelogenous leukemia (CML)
Bortezomib (Velcade)
proteasome inhibitor multiple myeloma (MM)
Crixivan
inhibits HIV protease
Captopril
inhibits ACE
Bevacizumab (Avastin)
anti-VEGF
tumor treatment
Infliximab (Remicade)
anti-TNFalpha
rheumatoid arthritis, interstitial bowel disease
Rituximab (Rituxan)
anti-CD20
B cell lymphoma, lupus, other autoimmune
DDI
inhibit reverse transcriptase (HIV replication)
AZT
inhibit reverse transcriptase (HIV replication)
cisplatin
alkylating agent; chemotherapeutic
actinomycin D
interfere with DNA by intercalation
Doxorubin (Adriamycin)
blocks DNA replication by intercalation
Puromycin
Nt analog that mimics tRNA acceptor region → termination of translation
Acylovir
Targets viral DNA polymerase → inhib. DNA replication
-herpes simplex virus; varicella zoster virus
Quinolones
target bacterial DNA gyrase
Tamoxifen
breast cancer therapy
Antagonizes estrogen by binding ER and preventing recruitment of HATs; sometimes recruits co-repressors in certain cell types
Cyclosporin
FK506
immunosuppressants inhibits cyclophillin (= activator of calcineurin)
Aspirin
Inhibits phosphorylation and degradation of IκB = prevents NFκB translocation to nucleus and inhibit. Inflamm cytokine transcription
Rapamycin
4E-BPs dephosphorylated, bind 4E → inhibit translation
targets mTor
Streptomycin, erythromycin, tetracycline, chloramphenicol
Target ribosome = target translation
Ritonavir
inhibits HIV protease (competitive inhibitor)
Methotrexate
Target = dihydrofolate reductase (key enzyme in nucleotide synthesis); mimics tetrahydrofolate; competitive inhibitor
Common cancer drug
Penicillin
Irreversibly inhibits component of bacterial wall synthesis
→ binds in glycopeptide transpeptidase → no peptidoglycan formation
Alpha-amantin
binds bridge helix; prevents translocation
Rifampicin
binds bacterial RNA polymerase and blocks the RNA exit channel
