Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

M2M > Drugs > Flashcards

Drugs Flashcards

1
Q

Vorinostat

A

inhibits HCAD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Gleevec

A

Bcr-abl tyrosine kinase inhibitor

Chronic myelogenous leukemia (CML)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Bortezomib (Velcade)

A 
proteasome inhibitor 
multiple myeloma (MM)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Crixivan

A

inhibits HIV protease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Captopril

A

inhibits ACE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Bevacizumab (Avastin)

A

anti-VEGF

tumor treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Infliximab (Remicade)

A

anti-TNFalpha

rheumatoid arthritis, interstitial bowel disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Rituximab (Rituxan)

A

anti-CD20

B cell lymphoma, lupus, other autoimmune

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

DDI

A

inhibit reverse transcriptase (HIV replication)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

AZT

A

inhibit reverse transcriptase (HIV replication)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

cisplatin

A

alkylating agent; chemotherapeutic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

actinomycin D

A

interfere with DNA by intercalation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Doxorubin (Adriamycin)

A

blocks DNA replication by intercalation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Puromycin

A

Nt analog that mimics tRNA acceptor region → termination of translation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Acylovir

A

Targets viral DNA polymerase → inhib. DNA replication

-herpes simplex virus; varicella zoster virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Quinolones

A

target bacterial DNA gyrase

17
Q

Tamoxifen

A

breast cancer therapy
Antagonizes estrogen by binding ER and preventing recruitment of HATs; sometimes recruits co-repressors in certain cell types

18
Q

Cyclosporin

FK506

A 
immunosuppressants
inhibits cyclophillin (= activator of calcineurin)
19
Q

Aspirin

A

Inhibits phosphorylation and degradation of IκB = prevents NFκB translocation to nucleus and inhibit. Inflamm cytokine transcription

20
Q

Rapamycin

A

4E-BPs dephosphorylated, bind 4E → inhibit translation

targets mTor

21
Q

Streptomycin, erythromycin, tetracycline, chloramphenicol

A

Target ribosome = target translation

22
Q

Ritonavir

A

inhibits HIV protease (competitive inhibitor)

23
Q

Methotrexate

A

Target = dihydrofolate reductase (key enzyme in nucleotide synthesis); mimics tetrahydrofolate; competitive inhibitor
Common cancer drug

24
Q

Penicillin

A

Irreversibly inhibits component of bacterial wall synthesis

→ binds in glycopeptide transpeptidase → no peptidoglycan formation

25
Q

Alpha-amantin

A

binds bridge helix; prevents translocation

26
Q

Rifampicin

A

binds bacterial RNA polymerase and blocks the RNA exit channel

M2M (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions