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Antimicrobial Therapy and Prophylaxis (2023) > Drugs > Flashcards

Drugs Flashcards

1
Q

(PEG-)Interferon

A
  • HCV
  • acts via JAK/STAT -> stimulating innate immunity
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2
Q

Ribavirin

A
  • HCV, Influenza
  • nucleoside analouge
    • substrate competition in guanine synthesis
    • incorporation into growing RNA
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3
Q

-previr

A
  • HCV
  • NS3/4A protease-inhibitor
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4
Q

-asvir

A
  • HCV
  • NS5A protease-inhibitor
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5
Q

-buvir

A
  • HCV
  • NS5B polymerase-inhibitor
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6
Q

Sofosbuvir

A
  • HCV
  • nucleoside inhibitor
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7
Q

Dasabuvir

A
  • HCV
  • non-nucleoside inhibitor
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8
Q

rVSV ZEBOV-GP

A
  • Ebola vaccine
  • recombinant GP in VSV
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9
Q

Zabdeno & Mvabea

A
  • Ebola vaccine
  • two dose regimen
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10
Q

Tetrandine

A
  • Ebola
  • entry inhibitor (two-pore channel 2)
  • targeting host
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11
Q

Compound 2e

A
  • Ebola
  • entry inhibitor (GP-related) -> inhibition of Cathepsin B cleavage
  • targets host
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12
Q

ZMapp

A
  • Ebola
  • combination of 3 humanised mAB
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13
Q

mAB 114

A
  • Ebola
  • mAB
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14
Q

REGN-EB3

A
  • Ebola
  • 3 human mAB
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15
Q

Nilotinib & Imatinib

A
  • Ebola
  • assembly and maturation inhibitor
  • inhibition of thyrosine kinase -> less virus budding
  • targets host
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16
Q

Remdesivir

A
  • Corona, Ebola
  • adenosine analog
  • stalls RdRp after 3 more nucleotides
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17
Q

Anakinra

A
  • Corona
  • immune modulation
  • IL-1 receptor blocker -> anti inflammatory
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18
Q

Nirmetralvir

A
  • Corona
  • protease inhibitor
19
Q

Paxlovid

A
  • Corona
  • combination of Nirmetralvir and Ritonavir
  • protease inhibitor with slower breakdown
20
Q

Varivax

A
  • herpes (VZV)
  • attenuated vaccine against chickenpox (OKA strain)
21
Q

Shingrix

A
  • herpes (VZV)
  • recombinant VZV GP E
22
Q

Acyclovir

A
  • herpes (α)
  • polymerase inhibitor
  • purine analog (G)
    • missing 3‘-OH
23
Q

Ganciclovir

A
  • herpes (α, β)
  • polymerase inhibitor
  • purine analog
  • side effects
24
Q

Penciclovir

A
  • herpes (α)
  • polymerase inhibitor
  • purine analog
  • longer half-life
25
Q

Famciclovir

A

prodrug of Penciclovir
- herpes (α)
- polymerase inhibitor
- purine analog

26
Q

Codofovir

A
  • herpes (α)
  • polymerase inhibitor
  • pyrimidine analog
  • side effects
27
Q

Brivudin

A
  • herpes (α)
  • polymerase inhibitor
  • pyrimidine analog
28
Q

Foscarnet

A
  • herpes (α)
  • polymerase inhibitor
  • non-nucleoside inhibitor -> allosteric
29
Q

Letermovir

A
  • herpes (HCMV)
  • HCMV terminase inhibitor
30
Q

Maribavir

A
  • herpes
  • assembly inhibitor
31
Q

Pritelivir

A
  • herpes (HSV)
  • helicase/primase inhibitor
32
Q

Amenamevir

A
  • herpes (HSV, VZV)
  • helicase/primase inhibitor
33
Q

Amantadine

A
  • Influenza
  • M2 proton channel inhibitor
34
Q

Favipiravir

A
  • broad-spectrum antiviral (Influenza, Ebola, Lassa, Noro)
  • nucleoside analog
35
Q

Baloxavir

A
  • Influenza
  • inhibitor of cap-snatching endonuclease (polymerase inhibitor)
36
Q

Oseltamivir

A
  • Influenza -> Tamiflu
  • neuraminidase inhibitor
37
Q

Zanamivir

A
  • Influenza -> Relenza
  • neuraminidase inhibitor
38
Q

NRTIs

A
  • Zidovudine
  • Stavudine
  • Zalcitabine
  • Didanosine
  • Emtricitabine
  • Lamivudine
  • Abacavir
  • Delavirdine
39
Q

NNRTIs

A
  • Nevirapine
  • Efavirenz
  • Rilpivirine
  • Etrvirine
40
Q

INSTIs

A
  • HIV integrase strand transfer inhibitor
  • -gravir
41
Q

HIV protease inhibitors (PI)

A
  • -navir
42
Q

Maraviroc

A
  • HIV
  • entry inhibitor (CCR5 antagonist)
  • severe side effects
43
Q

Enfuvirtide

A
  • HIV
  • entry inhibitor (fusion)

Antimicrobial Therapy and Prophylaxis (2023) (13 decks)

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