Drugs Flashcards
1
Q
(PEG-)Interferon
A
- HCV
- acts via JAK/STAT -> stimulating innate immunity
2
Q
Ribavirin
A
- HCV, Influenza
- nucleoside analouge
- substrate competition in guanine synthesis
- incorporation into growing RNA
3
Q
-previr
A
- HCV
- NS3/4A protease-inhibitor
4
Q
-asvir
A
- HCV
- NS5A protease-inhibitor
5
Q
-buvir
A
- HCV
- NS5B polymerase-inhibitor
6
Q
Sofosbuvir
A
- HCV
- nucleoside inhibitor
7
Q
Dasabuvir
A
- HCV
- non-nucleoside inhibitor
8
Q
rVSV ZEBOV-GP
A
- Ebola vaccine
- recombinant GP in VSV
9
Q
Zabdeno & Mvabea
A
- Ebola vaccine
- two dose regimen
10
Q
Tetrandine
A
- Ebola
- entry inhibitor (two-pore channel 2)
- targeting host
11
Q
Compound 2e
A
- Ebola
- entry inhibitor (GP-related) -> inhibition of Cathepsin B cleavage
- targets host
12
Q
ZMapp
A
- Ebola
- combination of 3 humanised mAB
13
Q
mAB 114
A
- Ebola
- mAB
14
Q
REGN-EB3
A
- Ebola
- 3 human mAB
15
Q
Nilotinib & Imatinib
A
- Ebola
- assembly and maturation inhibitor
- inhibition of thyrosine kinase -> less virus budding
- targets host
16
Q
Remdesivir
A
- Corona, Ebola
- adenosine analog
- stalls RdRp after 3 more nucleotides
17
Q
Anakinra
A
- Corona
- immune modulation
- IL-1 receptor blocker -> anti inflammatory
18
Q
Nirmetralvir
A
- Corona
- protease inhibitor
19
Q
Paxlovid
A
- Corona
- combination of Nirmetralvir and Ritonavir
- protease inhibitor with slower breakdown
20
Q
Varivax
A
- herpes (VZV)
- attenuated vaccine against chickenpox (OKA strain)
21
Q
Shingrix
A
- herpes (VZV)
- recombinant VZV GP E
22
Q
Acyclovir
A
- herpes (α)
- polymerase inhibitor
- purine analog (G)
- missing 3‘-OH
23
Q
Ganciclovir
A
- herpes (α, β)
- polymerase inhibitor
- purine analog
- side effects
24
Q
Penciclovir
A
- herpes (α)
- polymerase inhibitor
- purine analog
- longer half-life
25
Q
Famciclovir
A
prodrug of Penciclovir
- herpes (α)
- polymerase inhibitor
- purine analog
26
Q
Codofovir
A
- herpes (α)
- polymerase inhibitor
- pyrimidine analog
- side effects
27
Q
Brivudin
A
- herpes (α)
- polymerase inhibitor
- pyrimidine analog
28
Q
Foscarnet
A
- herpes (α)
- polymerase inhibitor
- non-nucleoside inhibitor -> allosteric
29
Q
Letermovir
A
- herpes (HCMV)
- HCMV terminase inhibitor
30
Q
Maribavir
A
- herpes
- assembly inhibitor
31
Q
Pritelivir
A
- herpes (HSV)
- helicase/primase inhibitor
32
Q
Amenamevir
A
- herpes (HSV, VZV)
- helicase/primase inhibitor
33
Q
Amantadine
A
- Influenza
- M2 proton channel inhibitor
34
Q
Favipiravir
A
- broad-spectrum antiviral (Influenza, Ebola, Lassa, Noro)
- nucleoside analog
35
Q
Baloxavir
A
- Influenza
- inhibitor of cap-snatching endonuclease (polymerase inhibitor)
36
Q
Oseltamivir
A
- Influenza -> Tamiflu
- neuraminidase inhibitor
37
Q
Zanamivir
A
- Influenza -> Relenza
- neuraminidase inhibitor
38
Q
NRTIs
A
- Zidovudine
- Stavudine
- Zalcitabine
- Didanosine
- Emtricitabine
- Lamivudine
- Abacavir
- Delavirdine
39
Q
NNRTIs
A
- Nevirapine
- Efavirenz
- Rilpivirine
- Etrvirine
40
Q
INSTIs
A
- HIV integrase strand transfer inhibitor
- -gravir
41
Q
HIV protease inhibitors (PI)
A
- -navir
42
Q
Maraviroc
A
- HIV
- entry inhibitor (CCR5 antagonist)
- severe side effects
43
Q
Enfuvirtide
A
- HIV
- entry inhibitor (fusion)
