Drugs Flashcards
1
Q
What drugs, from the lecture, have active metabolites?
A
Morphine, codeine (prodrug), propanolol, diazepam
2
Q
Which drugs are taken through 1st pass metabolism more than 65% in the lungs?
A
Propanolol, meperidine, lidocaine, fentanyl, alfentanil, sufentanil
3
Q
How do you calculate rate of metabolism?
A
ROM = CO(C inflow - C outflow)
4
Q
Which drugs, from the lecture, induce histamine release?
A
Morphine, atracurium, mivacurium, protamine
5
Q
Which drugs, from the lecture, are strong inhibitors of CYP450 enzymes?
A
CCBs, erythromycin, fentanyl, cimetidine, antifungals
