Drugs Flashcards
Atrovastatin Lipitor dosage
High intensity, 40 to 80 mg
Moderate intensity, 10 to 20 mg
Rosuvastatin Crestor dosage
High intensity, 20 to 40 mg
Moderate intensity, 5 to 10
No low intensity
Simvastatin Zocor
No high intensity
Moderate intensity, 20 to 40
Low intensity, 10
Lovastatin Mevacor
No high intensity
Moderate intensity, 40 to 80 mg
Low intensity, 20
Pravastatin, Pravachol
No high intensity
Moderate intensity, 40 to 80 mg
Low intensity, 10 to 20 mg
Fluvastatin Lescol
No high intensity
Moderate intensity, 80 mg
Low intensity, 20 to 40 mg
Pitavaststin livalo
No high intensity
Moderate intensity one to 4 mg
No low intensity
Zetia dose
Only cholesterol absorption inhibitor on the market
10 mg daily go down go down now
Zetia action
Acts at the brush border of the small intestines and inhibits the absorption of cholesterol decreasing delivery of intestinal cholesterol to the liver. This causes a reduction in hepatic cholesterol stores, and an increase in clearance of cholesterol from the blood.
Zetia contraindications
Hypersensitive to components of the medicine, pregnancy, liver disease if used with satin
Bile acid resins drugs
Questran welchol
How does questran and welchol action
Decreases cholesterol absorption through the exogenous pathway decreases LDL cholesterol levels 15 to 30% increase HDL levels approximately 3%
Forms an insoluble complex is secreted in the feces
May increase triglyceride levels up to 15%??
Questran welchol
Questran welchol, contraindications
Fasting triglyceride levels greater than or equal to 300
Questran welchol side effects
G.I. related, abdominal pain, gas bloating, heartburn constipation
When should Questran and welchol
Be taken
Take with food at largest meal 1 to 4 times a day
It is available as a powder, granules and tablets. It can be mixed with hot water, applesauce, but not carbonated drinks thyroid meds, anabiotic’s vitamins, be taken separately to prevent interaction in decreasing bioavailability.
Niacin, what is it?
Naturally occurring the vitamin can improve cholesterol levels when use it does is 100 to 300 times the recommended daily vitamin allowance
Niacin action
Decreases VLDL synthesis in the liver inhibits Lipo lysis in adipose tissue and increases lipoprotein lipase activity
Niacin dosage
At least 1.5 g niacin daily titrated gradually.
Niacin contraindications
Hepatic dysfunction, severe, hypertension, persistent, hyperglycemia, acute gout, new onset, a fib, or cute peptic ulcers
Niacin side effects
Flushing itching take 325 mg of aspirin 30 minutes prior G.I. 
What labs you draw a niacin
Draw LFTs at six and 12 weeks and dose change to monitor
Does niacin work?
Niacin therapy does not lead to significant reduction in total or case, specific mortality, or recurrent cardiovascular events among people with or at risk of atherosclerotic cardiovascular disease a.k.a. it doesn’t work
What are Fibric acid derivatives?
Gemfibeozil loped ,fenofibrates tricor , fenofibric acid trilipix
What are fibric acid derivatives?
A class of lipid, lowering drugs, mainly affect, triglyceride and HDL cholesterol levels
Fibric  acid derivatives action
Simulation of lipoprotein lipase, which enhances the breakdown of the LDL to LDL cholesterol
Fibric dosage
Gemfibrozil given in 600 mg doses twice daily with breakfast and dinner
TriCor 145 mg daily, mixed hyperlipidemia
Tri core 48 to 145 mg hypertriglyceridemia
Fibric acid derivatives contraindications
Gallstone satanic renal dysfunction
Fibric acid derivative side effects
G.I., myopathy, when combined with statins, niacin
Monitor at six and 12 weeks and periodically there after
Do not give these with statins
What are prescription fish oils?
Lovaza, vascepa
What is lovaza
Omega-3 ethyl esters
Decrease TG increase LDL
Dose is 4 mg four capsules per day
Can be taken with statins
What is Vascepa
Lcosapent ethyl
Decrease TG less then LOVAZA
4 g four capsules per day
What two options can treat high triglyceride levels over 500 mg
LOVAZA, VASCEPA
What are adenosine triphosphate citrate lyase inhibitors
They are the newest class of LDL cholesterol in medication on the market
It is an enzyme of HMG-coa reductase in the cholesterol synthesis pathway
Inhibition of HCl reduces cholesterol biosynthesis in the liver and subsequently decreases LDL cholesterol by a regulation of LDL receptors ……. It increases LDL receptors in the liver so that the liver breaks down more fat.
Medication for Familia homozygous hyper cholesterolemia
MIPOMERSEN, LOMITAPID (severe liver, toxicity side effects)
ALRROCUMAB (PRALUENT) and EVOLOCUNAB(Repatha) are monoclonal antibodies at target PCSK9
These medication’s are usually sub queue
How high is a patient’s LDL with homozygous hyper cholesterolemia
LDL cholesterol levels greater than 600 at an early age
What medication’s are used for combination therapy for hyperlipidemia
Lovastatin/niacin (Advicor)
Simvastatin/niacin (Simcor)
Combining sentence with a cholesterol absorption, inhibitor as benefits and reducing LDL cholesterol and ASCVD events
What medication can bile acid resins be used with?
Statins niacin Fibric acid derivatives to enhance LDL cholesterol lowering
Atherosclerotic, cardiovascular disease, risk, enhancing factors
Chronic kidney disease, family, history of premature, inflammatory diseases, metabolic syndrome, persistent, elevated cholesterol, LDL greater than 160 non-HDL 190, 219, south, Asian ancestry, preeclampsia or premature menopause before age 40, elevated biomarkers HSCRP greater than two
