Drugs

Question 1

Pharmacodynamics

Answer 1

drug’s effects on the body systems

Question 2

Pharmacokinetics

Answer 2

body’s handling of the drug

Question 3

4 stages of pharmacokinetics

Answer 3

absorption, distribution, metabolism, excretion

Question 4

CVS drugs stopped morning of operation

Answer 4

ACEi, ARBs, Loop diuretics, Potassium sparing diuretics

Question 5

CVS drugs stopped 48hrs preop

Answer 5

NOACs - rivaroxaban, apixaban, edoxaban

+ Dabigatran (anti thrombin)

Question 6

when is edoxaban stopped 72 hrs preop

Answer 6

if eGFR 15-50

Question 7

when is dabigatran stopped 4 days preop

Answer 7

if abdo/pelvic/lower limb/neuro surgery

Question 8

3 pillars of anaesthesia

Answer 8

hypnosis, analgesia, paralysis

Question 9

paralysis drugs

Answer 9

NM blocking agents - suxamethonium, recouronium

Question 10

depolarizing NMB drug

Answer 10

suxamethonium

Question 11

non depolarizing NMB drug

Answer 11

Rocuronium

Question 12

which NMB used for RSI

Answer 12

suxamethonium

Question 13

what will you see happen to pt when. given suxamethonium

Answer 13

twitches for around 30-60 seconds

Question 14

NMB very quick onset and short action

Answer 14

suxamethonium so used for RSI to reduce risk of aspiration prior to securing the airway with endotracheal tube at intubation

Question 15

takes 3-10mins to work, offset 20-45mins

Answer 15

rocuronium

Question 16

when is suxamethonium contraindicated

Answer 16

penetrating eye injuries or acute narrow angle glaucoma, as suxamethonium increases intra-ocular pressure.
Burns and trauma pts (hyperkalaemia)

Question 17

potential complications of suxamethonium use

Answer 17

malignant hypertension, hyperkalaemia

Question 18

why is suxamethonium contraindicated in burns/trauma pts

Answer 18

hyperkalaemia