Drugs Flashcards
Pharmacodynamics
drug’s effects on the body systems
Pharmacokinetics
body’s handling of the drug
4 stages of pharmacokinetics
absorption, distribution, metabolism, excretion
CVS drugs stopped morning of operation
ACEi, ARBs, Loop diuretics, Potassium sparing diuretics
CVS drugs stopped 48hrs preop
NOACs - rivaroxaban, apixaban, edoxaban
+ Dabigatran (anti thrombin)
when is edoxaban stopped 72 hrs preop
if eGFR 15-50
when is dabigatran stopped 4 days preop
if abdo/pelvic/lower limb/neuro surgery
3 pillars of anaesthesia
hypnosis, analgesia, paralysis
paralysis drugs
NM blocking agents - suxamethonium, recouronium
depolarizing NMB drug
suxamethonium
non depolarizing NMB drug
Rocuronium
which NMB used for RSI
suxamethonium
what will you see happen to pt when. given suxamethonium
twitches for around 30-60 seconds
NMB very quick onset and short action
suxamethonium so used for RSI to reduce risk of aspiration prior to securing the airway with endotracheal tube at intubation
takes 3-10mins to work, offset 20-45mins
rocuronium
when is suxamethonium contraindicated
penetrating eye injuries or acute narrow angle glaucoma, as suxamethonium increases intra-ocular pressure.
Burns and trauma pts (hyperkalaemia)
potential complications of suxamethonium use
malignant hypertension, hyperkalaemia
why is suxamethonium contraindicated in burns/trauma pts
hyperkalaemia
