Drugs

Question 1

Competitive oxytocin antagonist? Main use?

Answer 1

Atosiban. Inhibits contractions

Question 2

Define tocolytics

Answer 2

Decrease uterine tone (e.g. atosiban)

Question 3

Main use of oxytocics?

Answer 3

Synthetic oxytocin’s

Increase the force of uterine contractions

Question 4

Explain use of bromocriptine.

Answer 4

It is a dopamine agonist which suppresses prolactin secretion

Question 5

Compare bromocriptine and haloperidol

Answer 5

Bromocriptine = dopamine agonist that inhibits prolactin 
Haloperidol = dopamine antagonist that promotes prolactin

Question 6

Explain use of somatotropin

Answer 6

Recombinant hGH

Used for growth defects and abused in sport

Question 7

Compare mecasermin and somatotropin

Answer 7

Similar effect.
Somatotropin = recombinant hGH
Mecasermin = recombinant hIGF1

Question 8

Name the drug that is recombinant IGF1

Answer 8

Mecasermin

Question 9

Name a somatostatin agonist used to inhibit GH excess

Answer 9

Octreotride

Question 10

What benefit does tetrabenazine have in Huntington’s disease?

Answer 10

Treats chorea

Question 11

How does tetrabenazine treat chorea?

Answer 11

• dopamine competitive antagonist

- blocks actions of VMATs

Question 12

Why would benzatropine, a MACh antagonist, be helpful in Parkinson’s?

Answer 12

Reduces ACh (excitatory neurotransmitter)

Question 13

Explain the use of cholinesterase inhibitors in Alzheimer’s

Answer 13

Increases the concentration of ACh in the synaptic cleft which improves memory, attention and mood

Question 14

Name main drug used in ALS

Answer 14

Riluzole

Question 15

Does riluzole increase or decrease excitatory neurotransmitters?

Answer 15

Decreases

Question 16

Alendronate and risdronate are examples of…

Answer 16

Second generation biophosphonates

Question 17

How do you recognise a biphosphonate?

Answer 17

Suffix -onate

Question 18

Raloxifene (used in osteoporosis) is an example of which class of drug?

Answer 18

SERM - selective oestrogen receptor modulator

Question 19

Prednisolone and dexamethasone are examples of…

Answer 19

Synthetic glucocorticoids

Question 20

How does oxytocin stimulate milk ejection?

Answer 20

Binds to myoepithelial cell. Activates PLC as second messenger which splits into IP3 and DAG. IP3 binds to SR and causes release of calcium. Calcium binds to troponin which allows actin ant myosin cross bridging to form. This causes contraction of the muscle and ejection of the milk down the duct.

Question 21

Name synthetic T4

Answer 21

Levothyroxine

Question 22

Name synthetic T3

Answer 22

Liothyronine

Question 23

Mesalamine is also known as…

Answer 23

Mesalizine

Question 24

What is sulfasalazine

Answer 24

Conjugated mesalamine

Question 25

Prednisone and budesonide are examples of which class of drugs

Answer 25

Glucorticoids

Question 26

Mercaptopurine is an immunosuppressant used for which condition?

Answer 26

Severe IBD

Question 27

Name a monoclonal antibody used for IBD

Answer 27

Infliximab
Adalimumab
Golimumab

Question 28

Monoclonal antibodies are contraindicated in which patients?

Answer 28

Those with a history of TB, fungal infections, hep B

Because these diseases can resurface while on these drugs

Question 29

Dose of MTX for Crohn’s?

Answer 29

15-20mg / week