Drug Transporters

Question 1

What are ABC proteins?

Answer 1

• ATP-binding cassette
• efflux transporters
• use energy

Question 2

What are SLC proteins?

Answer 2

• Solute-linked carrier
• influx transporters
• Does not use energy

Question 3

Examples of ABC efflux transporters

Answer 3

PgP
Breast Cancer Resistance Proteins (BCRP)
MRP

Question 4

Explain saturation of intestinal efflux transporters

Answer 4

• The impact of the efflux transporter i significant when the concentration of substrate is LOW.
• When the efflux transporters are saturated the effect of them is likely to be negligable.
• Therefore impact of P-gP more pronounced for drugs which have a very slow dissolution rate or poor inherent passive diffusion.

Question 5

Examples of SLC influx transporters

Answer 5

OATP (Organic Anion Transporting Protein)