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Study Group Pharmacology > Drug Toxicities > Flashcards

Drug Toxicities Flashcards

1
Q

Aplastic anemia

A

Can’t Make New Blood Cells Properly: Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil

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2
Q

Atropine-like Side Effects

A

Tricyclics

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3
Q

Dilated cardiomyopathy

A

Doxorubicin, Daunorubicin

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4
Q

Cinchonism

A

quinidine, quinine

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5
Q

Coronary steal phenomenon

A

dipyridamole

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6
Q

Corneal micro deposits

A

amiodarone, chlorpromazine

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7
Q

Cough

A

ACE inhibitors

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8
Q

Diabetes insipidus

A

lithium, demeclocycline

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9
Q

difsulfiram-like effect

A

metronidazole, sulfonylureas 1st generation

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10
Q

Extrapyramidal side effects

A

Antipsychotics (HIGH potency - Haloperidol; LOW potency - Chlorpromazine, Thioridazine)

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11
Q

Fanconi’s Syndrome - disease of proximal renal tubules –> glucose, amino acids, uric acid, phosphate, bicarbonate passed into urine and not reabsorbed

A
  • expired tetracycline
  • HIV drug regimen with tenofovir and didanosine
  • lead poisoning
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12
Q

Focal to massive hepatic necrosis

A

“Liver HAVAc”: Halothane, Amanita phalloides (death cap), Valproic acid, Acetaminophen

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13
Q

gingival hyperplasia

A

Very Pink Chunky Nums (gums):

Verapimil, Phenytoin, Cyclosporine, Nifedipine

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14
Q

grey baby syndrome

A

chloramphenicol

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15
Q

gynecomastia

A

cimetidine, azoles, spironolactone, digitalis, estrogen&testosterone, isoniazid and ethionamide, clomiphene, phenytoin, reserpine and methydopa

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16
Q

hand foot syndrome - erythema, numbness, and desquamation of palms and soles

A

5-fluorouracil

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17
Q

hemolytic anemia in G6PD deficiency

A

Hemolysis IS D PAIN:

Isoniazid, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

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18
Q

hemorrhagic cystitis

A

cyclophosphamide, ifosfamide

-prophylaxis with Mesna and treat with acetylcysteine bladder wash

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19
Q

hepatitis

A

isoniazid

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20
Q

cutaneous flushing

A

VANC - Vancomycin, Adenosine, Niacin, Ca2+ channel blockers

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21
Q

postural hypertension

A

prazosin

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22
Q

rebound hypertension

A

clonidine withdrawal

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23
Q

increased intracranial tension

A

amiodarone, hypervitaminosis A, OCPs, tetracycline, quinolones

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24
Q

Inducers of CP450

A

barbituates, phenytoin, carbamazepine, rifampin

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25
Q

Inhibitors of CP450

A

cimetidine, erythromycin, ketoconazole, isoniazid

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26
Q

Interstitial nephritis

A

methicillin, NSAIDs (except aspirin), furosemide, sulfonamides

27
Q

milk alkali syndrome

A

calcium carbonate

28
Q

Monday disease - headache, tachycardia, and dizziness upon re-exposure to drug

A

nitroglycerin industrial exposure

29
Q

nephrotoxicity

A

cephaloridine, gentamicin, amphotericin B

30
Q

orange body fluids

A

rifampin

31
Q

osteoporosis

A

heparin, corticosteroids

32
Q

pancreatitis

A

Drugs Causing A Lengthy Violent Abdominal Distress:

Didanosine, Corticosteroids, Alcohol, L-asparaginase, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ)

33
Q

photosensitivity

A

SAT For Photo Quietly: Sulfonamides, Amiodarone, Tetracyclines, 5-FU, Quinolones (lomefloxacin, pefloxacin)

34
Q

Direct Coombs-positive hemolytic anemia

A

methyldopa, penicillin

35
Q

pulmonary fibrosis

A

bleomycin, amiodarone

36
Q

Rabbit syndrome - perioral tremors

A

phenothiazine

37
Q

red man syndrome

A

vancomycin (rapid IV)

38
Q

severe hypertension with tyramine ingestion

A

MAOIs

39
Q

Drug-induced lupus (anti-histone antibody characteristic of this condition)

A

Q-CHIMPPP So Eager: Quinidine, Chlorpromazine, Hydralazine, Isoniazid, Methyldopa, Procainamide, Penicillamine, Phenytoin, Sulfa drugs, Etanercept

40
Q

Tardive dyskinesia

A

antipsychotics with long-term use, metoclopramide

41
Q

tinnitus

A

aspirin, quinidine

42
Q

torsades de pointes

A

terfenadine, Class III (sotalol) and Class IA (quinidine) antiarrhythmics, macrocodes, antipsychotics, TCAs

43
Q

coronary vasospasm

A

cocaine, sumatriptan, ergot alkaloids

44
Q

Adrenocortical insufficiency

A

HPA suppression secondary to glucocorticoid withdrawal

45
Q

hot flashes

A

tamoxifen, clomiphene

46
Q

hyperglycemia

A

Take Pills Necessitates Having Blood Checked:

Tacrolimus, Protease Inhibitors, Niacin, HCTZ, Beta blockers, Corticosteroids

47
Q

hypothyroidism

A

lithium, amiodarone, sulfonamides

48
Q

Acute cholestatic hepatitis and jaundice

A

erythromycin

49
Q

diarrhea

A

Might Excite Colon On Accident: Metformin, Erythromycin, Colchicine, Orlistat, Acarbose

50
Q

Pseudomembranous colitis

A

clindamycin, ampicillin, cephalosporins –> predispose to superinfection by resistant C. difficile

51
Q

agranulocytosis

A

Drugs CCCrush Myeloblasts and Promyelocytes:

Dapsone, Clozapine, Carbamezepine, Colchicine, Methimazole, Propylthiouracil

52
Q

MegaloBLASTic anemia

A

Having a BLAST with PMS:

Phenytoin, Methotrexate, Sulfa drugs

53
Q

Thrombocytopenia

A

heparin, cimetidine

54
Q

Thrombotic complications

A

OCPs (estrogens)

55
Q

Fat redistribution

A

Fat PiG: Protease inhibitors, Glucocorticoids

56
Q

Hyperuricemia/Gout

A

Painful Tophi and Feet Need Care:

Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine

57
Q

myopathy

A

fibrates, niacin, colchicine, hydroxychloroquine, interferon-alpha, penicillamine, statins, glucocorticoids

58
Q

Rash (Stevens-Johnson syndrome)

A

Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin: Anti-epileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital), Allopurinol, Sulfa drugs, Penicillin

59
Q

teeth discoloration

A

tetracyclines

60
Q

tendonitis, tendon rupture, cartilage damage

A

fluoroquinolones

61
Q

Parkinson-like syndrome

A

cogwheel rigidity of ARM: Antipsychotics, Reserpine, Metoclopramide

62
Q

Seizures

A

With seizures, I BITE My tongue: Isoniazid (B6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide

63
Q

SIADH

A

Can’t Concentrate Serum Sodium:

Carbamazepine, Cyclophosphamide, SSRIs

Study Group Pharmacology (16 decks)

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