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Study Group Pharmacology > Drug Toxicities > Flashcards

Drug Toxicities Flashcards

1
Q

Aplastic anemia

A

Can’t Make New Blood Cells Properly: Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil

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2
Q

Atropine-like Side Effects

A

Tricyclics

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3
Q

Dilated cardiomyopathy

A

Doxorubicin, Daunorubicin

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4
Q

Cinchonism

A

quinidine, quinine

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5
Q

Coronary steal phenomenon

A

dipyridamole

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6
Q

Corneal micro deposits

A

amiodarone, chlorpromazine

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7
Q

Cough

A

ACE inhibitors

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8
Q

Diabetes insipidus

A

lithium, demeclocycline

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9
Q

difsulfiram-like effect

A

metronidazole, sulfonylureas 1st generation

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10
Q

Extrapyramidal side effects

A

Antipsychotics (HIGH potency - Haloperidol; LOW potency - Chlorpromazine, Thioridazine)

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11
Q

Fanconi’s Syndrome - disease of proximal renal tubules –> glucose, amino acids, uric acid, phosphate, bicarbonate passed into urine and not reabsorbed

A
  • expired tetracycline
  • HIV drug regimen with tenofovir and didanosine
  • lead poisoning
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12
Q

Focal to massive hepatic necrosis

A

“Liver HAVAc”: Halothane, Amanita phalloides (death cap), Valproic acid, Acetaminophen

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13
Q

gingival hyperplasia

A

Very Pink Chunky Nums (gums):

Verapimil, Phenytoin, Cyclosporine, Nifedipine

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14
Q

grey baby syndrome

A

chloramphenicol

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15
Q

gynecomastia

A

cimetidine, azoles, spironolactone, digitalis, estrogen&testosterone, isoniazid and ethionamide, clomiphene, phenytoin, reserpine and methydopa

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16
Q

hand foot syndrome - erythema, numbness, and desquamation of palms and soles

A

5-fluorouracil

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17
Q

hemolytic anemia in G6PD deficiency

A

Hemolysis IS D PAIN:

Isoniazid, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

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18
Q

hemorrhagic cystitis

A

cyclophosphamide, ifosfamide

-prophylaxis with Mesna and treat with acetylcysteine bladder wash

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19
Q

hepatitis

A

isoniazid

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20
Q

cutaneous flushing

A

VANC - Vancomycin, Adenosine, Niacin, Ca2+ channel blockers

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21
Q

postural hypertension

A

prazosin

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22
Q

rebound hypertension

A

clonidine withdrawal

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23
Q

increased intracranial tension

A

amiodarone, hypervitaminosis A, OCPs, tetracycline, quinolones

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24
Q

Inducers of CP450

A

barbituates, phenytoin, carbamazepine, rifampin

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25
Inhibitors of CP450
cimetidine, erythromycin, ketoconazole, isoniazid
26
Interstitial nephritis
methicillin, NSAIDs (except aspirin), furosemide, sulfonamides
27
milk alkali syndrome
calcium carbonate
28
Monday disease - headache, tachycardia, and dizziness upon re-exposure to drug
nitroglycerin industrial exposure
29
nephrotoxicity
cephaloridine, gentamicin, amphotericin B
30
orange body fluids
rifampin
31
osteoporosis
heparin, corticosteroids
32
pancreatitis
Drugs Causing A Lengthy Violent Abdominal Distress: | Didanosine, Corticosteroids, Alcohol, L-asparaginase, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ)
33
photosensitivity
SAT For Photo Quietly: Sulfonamides, Amiodarone, Tetracyclines, 5-FU, Quinolones (lomefloxacin, pefloxacin)
34
Direct Coombs-positive hemolytic anemia
methyldopa, penicillin
35
pulmonary fibrosis
bleomycin, amiodarone
36
Rabbit syndrome - perioral tremors
phenothiazine
37
red man syndrome
vancomycin (rapid IV)
38
severe hypertension with tyramine ingestion
MAOIs
39
Drug-induced lupus (anti-histone antibody characteristic of this condition)
Q-CHIMPPP So Eager: Quinidine, Chlorpromazine, Hydralazine, Isoniazid, Methyldopa, Procainamide, Penicillamine, Phenytoin, Sulfa drugs, Etanercept
40
Tardive dyskinesia
antipsychotics with long-term use, metoclopramide
41
tinnitus
aspirin, quinidine
42
torsades de pointes
terfenadine, Class III (sotalol) and Class IA (quinidine) antiarrhythmics, macrocodes, antipsychotics, TCAs
43
coronary vasospasm
cocaine, sumatriptan, ergot alkaloids
44
Adrenocortical insufficiency
HPA suppression secondary to glucocorticoid withdrawal
45
hot flashes
tamoxifen, clomiphene
46
hyperglycemia
Take Pills Necessitates Having Blood Checked: | Tacrolimus, Protease Inhibitors, Niacin, HCTZ, Beta blockers, Corticosteroids
47
hypothyroidism
lithium, amiodarone, sulfonamides
48
Acute cholestatic hepatitis and jaundice
erythromycin
49
diarrhea
Might Excite Colon On Accident: Metformin, Erythromycin, Colchicine, Orlistat, Acarbose
50
Pseudomembranous colitis
clindamycin, ampicillin, cephalosporins --> predispose to superinfection by resistant C. difficile
51
agranulocytosis
Drugs CCCrush Myeloblasts and Promyelocytes: | Dapsone, Clozapine, Carbamezepine, Colchicine, Methimazole, Propylthiouracil
52
MegaloBLASTic anemia
Having a BLAST with PMS: | Phenytoin, Methotrexate, Sulfa drugs
53
Thrombocytopenia
heparin, cimetidine
54
Thrombotic complications
OCPs (estrogens)
55
Fat redistribution
Fat PiG: Protease inhibitors, Glucocorticoids
56
Hyperuricemia/Gout
Painful Tophi and Feet Need Care: | Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine
57
myopathy
fibrates, niacin, colchicine, hydroxychloroquine, interferon-alpha, penicillamine, statins, glucocorticoids
58
Rash (Stevens-Johnson syndrome)
Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin: Anti-epileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital), Allopurinol, Sulfa drugs, Penicillin
59
teeth discoloration
tetracyclines
60
tendonitis, tendon rupture, cartilage damage
fluoroquinolones
61
Parkinson-like syndrome
cogwheel rigidity of ARM: Antipsychotics, Reserpine, Metoclopramide
62
Seizures
With seizures, I BITE My tongue: Isoniazid (B6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide
63
SIADH
Can't Concentrate Serum Sodium: | Carbamazepine, Cyclophosphamide, SSRIs

Study Group Pharmacology (16 decks)

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