Drug Therapy For Substace Abuse Flashcards

1
Q

What is substance abuse?

A

Maladaptive pattern of substance use, leading to clinically significant impairment or distress

Involves self administration of drug for prolonged periods, or an excessive amounts

There is no cure for addiction

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2
Q

What is psychological dependence?

A

Overwhelming desire to repeat drug use: either to produce pleasure or avoid the discomfort

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3
Q

Define intoxication

A

Reversible substance specific syndrome caused by recent ingestion, or exposure to a substance

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4
Q

What is physical dependence?

A

Chronic use of a drug to avoid withdrawal symptoms

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5
Q

Define withdrawal

A

Unpleasant symptoms when drug is stopped

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6
Q

Define tolerance

A

Increased doses are required to achieve desired effects

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7
Q

What is the drug of choice to treat alcohol withdrawal

A

Benzodiazepine

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8
Q

What the prototype of benzodiazepine for treatment of alcohol withdrawal

A

Chlordiazepoxide

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9
Q

Nursing considerations for chlordiazepoxide

A

Goal is to take drug while abstaining from alcohol to reduce withdrawal symptoms

BBW for combined use with opioids

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10
Q

What is the reversal agent for benzodiazepine?

A

Flumazenil

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11
Q

BBW for flumazenil

A

Risk of seizures

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12
Q

What is disulfiram?

A

Maintain state of alcohol sobriety

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13
Q

Nursing considerations for disulfiram

A

If patient consumes alcohol, side effects may include:

Headache, chest pain, seizures, N/V heart failure, myocardial infarction, death

BBW:

Patient must know what they are taking this medication

Not for patients who consumed alcohol in past 12 hours, or patients with heart conditions

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14
Q

How do you treat opioid abuse?

A

With an opioid agonist

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15
Q

What is the prototype opioid agonist for treating opiate abuse?

A

Methadone

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16
Q

What is the use for methadone?

A

Detoxification/maintenance therapy for opioid addiction

17
Q

Nursing considerations for methadone

A

BBW:

Only for use with an approved opioid addiction treatment program

Monitor for QT prolongation

18
Q

What is the prototype for an opioid antagonist/agonist for treatment of opioid abuse?

A

Buprenophine - naloxone

19
Q

Uses for buprenorphine - naloxone

A

Maintenance therapy for short acting opioid dependence

20
Q

Side effects for buprenorphine naloxone

A

BBW: buccal and transdermal routes have higher risk of addiction, abuse, and misuse leading to respiratory depression.

21
Q

Why can’t naloxone reverse the effects of buprenorphine

A

Buprenorphine has a (stronger binding) higher affinity to the opioid receptors

22
Q

MOA for buprenorphine naloxone

A

Buprenorphine block the opiate receptors to reduce urges; naloxone reverses effects of opioids