Drug Therapy

Question 1

What are the two types of antipsychotics?

Answer 1

Typical and Atypical

Question 2

What do typicals aim to do?

Answer 2

Reduce positive symptoms

Question 3

How do typicals reduce positive symptoms?

Answer 3

Reducing the effect of dopamine, by binding (not stimulating) the D2 receptors. This stops it reaching the limbic system.

Question 4

Whats the side effects of typicals? (3)

Answer 4

Tardive dyskinesia
Effects motor control (due to effect on extrapyramidal area)
Affects nigostriatial pathway.

Question 5

AO3 point for Typicals?

Answer 5

Davies et al.

Question 6

What did Davies do?

Answer 6

Meta analysis

Looked at relapse rate

Question 7

What did Davies find?

Answer 7

Placebos - 55% relapse rate

Typicals - 19% relapse rate

Question 8

Davies is a strength because…

Answer 8

he concluded that typicals were more effective than placebos

Question 9

Discussion for Davies et al.?

Answer 9

Ross and Reed

Question 10

Ross and Reed said that:

Answer 10

Prescribing medicine implies something is wrong with the individual
Creates a negative stigma
May lead to not addressing family issues that may go on to trigger relapse

Question 11

Ross and Reed is PRS for Drug therapy as:

Answer 11

It devalues the cognitive therapies and could go on to cause other symptoms of SZ because of the stigma.

Question 12

Atypicals aim to

Answer 12

reduce positive symptoms AND claims to reduce negative symptoms

Question 13

What do atypicals do?

Answer 13

Temporarily bind to D2 receptors
Rapidly dissassociate causing normal dopamine uptake
Atypicals have a higher affinity to serotonin 5-HT2A receptors
Excess serotonin linked to negative symptoms

Question 14

Side effects of Atypicals (4)

Answer 14

Reduction in WBC
Drooling
Weight gain
Reduction in apathy

Question 15

AO3 for atypicals

Answer 15

Awad and Vorgunanti

Question 16

Awad and Vogunanti found..

Answer 16

85% success rate in atypicals

65% in typicals

Question 17

Awad and Vorgunanti is a strength because

Answer 17

they concluded atypicals were more effective than typicals

Question 18

Discussion for Awad and Vorgunanti

Answer 18

Patients must remember to take meds
If not may relapse
Skew data on relapse rate and effectiveness

Question 19

AO3+

Answer 19

Leucht et al

Question 20

Leucht conducted a —- to assess

Answer 20

meta analysis

to assess 4 atypicals

Question 21

Leucht found…

Answer 21

all more effective than placebo

Risperidone was the most effective

Question 22

This is GRS for drug therapy as it

Answer 22

suggests that atypicals can in fact treat SZ effectively