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Medsci 204 > Drug Targets > Flashcards

Drug Targets Flashcards

1
Q

What are 2 examples of extracts from plants and herbs?

A
  • Morphine from opium poppies => pain killer, induces euphoria
  • Digitalis/Digoxin from foxglove => reversible inhibitor of Na/K ATPase, treats congestive heart failure
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2
Q

Digoxin

A

Reversible inhibitor of Na/K ATPase

Treats congestive heart failure

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3
Q

Penicillin

A

B-lactam antibiotic

Interferes with bacterial wall synthesis

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4
Q

What are 3 examples of endogenous drugs?

A

Insulin
Thyroxine
Growth hormone

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5
Q

What are some examples of endogenous compounds that have been chemically modified?

A

HORMONAL
Ethinyl estradiol - more stable form of oestrogen
Prednisolone - synthetic steroid, glucocorticoid-like action

ANTI-CANCER
6-mercaptopurine
6-thioguanine
(alternate base pairs, effect cancer cells most due to rapid repliction)

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6
Q

What are 4 examples of chemically synthesised drugs?

A

Indomethacin, celecoxib - COX inhibitors (NSAIDs)
Cimetidine - histamine reseptor modulator
Simvastatin - HMG-CoA reductase inhibtor

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7
Q

Some drugs discovered by chance are…

A

Viagra
Antidepressants monoamine oxidases (Tb) and tricyclic (pre-anaesthetic agents)
Cisplatin - effects of electrical fields on bacterial growth

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Medsci 204 (2 decks)

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