Drug Safety Issues

Question 1

What drugs should you avoid if cancer is present?

Answer 1

pioglitazone, dapagliflozin (bladder CA), GLP-1 RAs (thyroid, incl. medullary thyroid CA (MTC))

Question 2

What drugs should you avoid if the patient is elderly?

Answer 2

Sulfonylureas, due to risk of hypoglycemia

Question 3

What drugs should you avoid if gastroparesis, GI disorders are present?

Answer 3

GLP-1 RAs, pramlintide

Question 4

What drugs should you avoid if genital infxn/UTI’s are present?

Answer 4

SGLT2i

Question 5

What drugs should you avoid if heart failure is present?

Answer 5

TZDs, alogliptin, saxagliptin

Question 6

What drugs should you avoid if hepatotoxicity is present?

Answer 6

TZDs, alogliptin

Question 7

What drugs should you avoid if hypolgycemia is a concern?

Answer 7

insulin, SU, meglinitides if the dose is taken but the meal is skipped

Question 8

What drugs should you avoid if hypotension/dehydration is a concern?

Answer 8

SGLT2i

Question 9

What drugs should you avoid if hyperkalemia is a concern?

Answer 9

canagliflozin

Question 10

What drugs should you avoid if hypokalemia is a concern?

Answer 10

insulin

Question 11

What drugs should you avoid if hypersensitivity is a concern?

Answer 11

DPP-4i

Question 12

What drugs should you avoid if ketoacidosis is a concern?

Answer 12

SGLT2i (RF are acute illness, dehydration, renal impairment)

Question 13

What drugs should you avoid if lactic acidosis is a concern?

Answer 13

metformin

Question 14

What drugs should you avoid if osteopenia/osteoporosis is a concern?

Answer 14

canagliflozin, TZDs

Question 15

What drugs should you avoid if pancreatitis is a concern?

Answer 15

DPP-4i and GLP-1 RAs

Question 16

What drugs should you avoid if peripheral neuropathy, PAD, and foot ulcers are a concern?

Answer 16

canagliflozin

Question 17

What drugs should you avoid if retinopathy is a concern?

Answer 17

semaglutide injection

Question 18

What drugs should you avoid if sulfa allergy, severe is a concern?

Answer 18

SU’s, or use it cautiously

Question 19

What drugs should you avoid if renal insufficiency is a concern?

Answer 19

metformin, SGLT2i, exenatide, glyburide

Question 20

What drugs should you avoid if weight gain is a concern?

Answer 20

risk with sulfonylureas, meglitinides, TZDs, and insulin