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Year 3 > Drug Revision > Flashcards

Drug Revision Flashcards

1
Q

Name some cytochrome P450 inhibitors

A 
SOFA ACCCA
sodium valporate
omeprazole (ppi)
fluoxitine (SSRIs)
Antibiotics (erythromycin, ciprofloxacin, clarithromycin, isonizaid, metronidazole)
anti-fungals (fluconazole, miconazole)
calcium channel blockers e.g. diltiazem
cranberry and grapefruit juice
cimetidine
Amiodarone
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2
Q

The most important P450 inhibitors

A 
clarithromycin
ciprofloxacin
erythromycin
miconazole
sodium valporate
juice
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3
Q

Substrates of cytochrome p450

A 
CCCOW PATS PLODS
corticosteroids
carbamezapine
clopidogrel
OCP
warfarin

phenytoin
amitryptaline (and ssri)_
theophylline
statins

painkillers- paracetamol, NSAIDs, opioids, benzodiazepines
losartan
omeprazole
donepazil
sodium valporate
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4
Q

Most important P450 substrates

A 
warfarin
OCP
theophylline
carbamezapine
phenytoin
corticosteroids
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5
Q

Inducers of cytochrome P450

A 
CRAPS GBS
Carbamezapine
Rifampicin
Alcohol
Phenytoin

Gliclazides (sulphonylureas)
Barbituates
St John’s Wort

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6
Q

Drugs that can cause a flare of gout

A 
beta-blockers
aspirin
niacin
diuretics
ACE inhibitors

BANDA

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7
Q

Drugs that can lower folate level and cause macrocytic anaemia

A

MAT D
methotrexate
anti-epileptics
trimethoprim

drugs

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8
Q

Nephrotoxic drugs

A 
DIAMOND HAL
diuretics
iv contrast (iodine)
ace-inhibitor
metformin
opioids
Nsaids
Digoxin

Heparin
Aminoglycosides
Lithium

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9
Q

Drugs that cause HYPOkalaemia

A

Diuretics- loop and thiazide
corticosteroids (mainly mineral)
Combination of beta-2 agonists, theophylline and corticosteroids

stimulant laxatives- senna
Hypokalaemia causes digoxin toxicity

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10
Q

Drugs that cause HYPERkalaemia

A 
PAPATs
potassium
ACE-i
Postassium sparing diuretics
ARBs
Trimethoprim
spironolactone
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11
Q

Drugs that cause HYPOtension

A 
Tricylcic antidepressants
Nitrates
Diuretics
Adenosine
Amiodarone
ACE-i/ARBs
Alpha-blockers - doxazosin
Dopaminergic drugs- L-dopa
Fibrinolytics- aletplase
Phosphodiesterase inhibitors- sildanefil

SANDAL DATA

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12
Q

drugs that lower the seizure threshold

A 
opioids
SSRI's
tricyclics
quinlones (ciprofloxacin)
cephalosporins
carbapenems
metronidazole -SE
methotrexate- SE
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13
Q

Drugs that prolong the QT interval

A 
SSRIs
Tricyclic anti-depressants
antifungals
macrolides- erythro and clarithro
Quinolones- ciprofloxacin
Hypokalaemia
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14
Q

Drugs that raise blood glucose

A 
barbituates
thiazide diuretics
corticosteroids
birth control
niacin
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15
Q

Drugs that have a low therapeutic index

A 
guys with large dongles totally make perfect internet connection
gentamicin
warfarin
lithium
digoxin
theophylline
methotrexate
phenytoin
insulin
ciclosporin
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Year 3 (2 decks)

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