Drug Receptors Flashcards
What does an agonist do?
Produces/promotes a similar response to the intended chemical
(acts like the ligand on the target receptor)
What does an antagonist do?
Blocks the effect of the ligand on the target receptor
How can two different drugs have the same result for a patient? Example: pt with COPD and pt with Asthma, both have constricted bronchioles but two different drugs could treat them.
One drug (sympathetic beta2 activation) causes bronchial dilation and one drug (parasympathetic m3 antagonism) blocks constriction….both lead to the same end result of opening bronchioles
What does pharmacology study?
At the receptor level, what is the mechanism of action?
Ex: Beta 2 agonist, M3 antagonist
What does pharmacodynamics (PD) study?
What is the physiological effect of the drug on the body?
Ex: dilates bronchial tubes, increases HR
What does pharmacokinetics (PK) study?
What does the body do to the drug?
ADME
What does pharmacotherapy study?
Choosing which drug is best for the pt
What does a modulator drug do?
Has both agonist and antagonist effects
What channels have quick acting effects?
Ligand-gated ion channels and G protein-coupled receptors
5 protein subunits form the _____ of a ion channel
Pore
T/F a specific ion channel let ions flow in and out of a cell
False. Ion channels either allow ions into a cell OR out of a cell (one way flow)
How are voltage gated ion channels activated?
By a charge, activation of one leads to activation of the next one and so on
T/F Voltage gated ion channels are specific for one ion
True
Voltage gated ion channels do not require a _____
Ligand
Where are voltage-gated ion channels found?
On nerves
What is an example of a drug that uses a voltage-gated channel?
Lidocaine (antagonist) it blocks voltage-gated Na+ receptors which blocks Na+ permeability
How do ligand gated ion channels work?
A endogenous ligand binds to a subunit of the pore which causes the permeability of the channel and allows ions to flow through it