Drug Receptor Interaction

Question 1

Define Agonist, Antagonist, Potency, Affinity, Efficacy, Full agonist, Partial agonist, Selectivity

Answer 1

Look at lecture - pretty straight forward

Question 2

Describe the drug target sites

Answer 2

1. Receptors :
2. Ion channels
3. Transport system
4. Enzymes

LOOK AT LECTURE NOTES FOR EXAMPLES

Question 3

Describe the structure activity relationship and the graph

Answer 3

Emphasises the relationship between the structure of the drug and its activity.

LOOK at graph

Question 4

Explain the difference between competitive and irreversible antagonists

Answer 4

1. Competitive: binds to same site so by increasing agonist you reduce the effect of the antagonist (Eg Atropine and propanalol)
2. Irreversible: tightly bound to same sight or not the same (covalently) (Eg hexamethanium blocks nicotine ion channel)

EFFECT OF ANTAGONIST GRAPHS