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Specialities > Drug Reactions, Interactions and Side Effects > Flashcards

Drug Reactions, Interactions and Side Effects Flashcards

1
Q

What are the characteristic side effects of methotrexate?

A
  • Myelosuppression
  • Liver cirrhosis
  • ILD/Pneumonitis
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2
Q

What are the characteristic side effects of sulfasalazine?

A
  • Rashes
  • Oligospermia
  • Heinz body/Megaloblastic anaemia
  • Intersitial lung disease
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3
Q

What are the characteristic side effects of Leflunomide?

A
  • Liver impairment
  • Interstitial lung disease
  • HTN
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4
Q

What are the characteristic side effects of hydroxychloroquine?

A
  • Retinopathy

- Corneal deposits

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5
Q

What are the characteristic side effects of prednisolone?

A
  • Cushingoid features
  • Osteoporosis
  • Impaired glucose tolerance
  • HTN
  • Cataracts
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6
Q

What are the characteristic side effects of Gold?

A
  • Proteinuria
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7
Q

What are the characteristic side effects of penicillamine?

A
  • Proteinuria

- Exacerbation of myasthenia gravis

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8
Q

What are the characteristic side effects of infliximab?

A
  • Reactivation of TB, HBV

- Demyelinating disease

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9
Q

What are the characteristic side effects of azothiaprine?

A
  • SCC
  • Lymphoma
  • Gout
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10
Q

What are the characteristic side effects of axomicillin?

A

Rash with infectious mononucleosis

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11
Q

What are the characteristic side effects of co-amoxiclav?

A

Cholestasis

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12
Q

What are the characteristic side effects of flucloxacillin?

A

Cholestasis (usually several weeks after use)

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13
Q

What are the characteristic side effects of erythromycin?

A

GI upset

Prolonged QT

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14
Q

What are the characteristic side effects of ciproflaxacin?

A
  • Lowers seizure threshold

- Tendonitis

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15
Q

What are the characteristic side effects of metronidazole?

A
  • Reaction following alcohol ingestion
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16
Q

What are the characteristic side effects of doxycycline?

A
  • Photosensitivity
17
Q

What are the characteristic side effects of trimethoprim?

A
  • Rashes, inc photosensitivity
  • Pruritus
  • Suppression of haematopoiesis
18
Q

What is the mechanism of action of sildenafil?

A

Phosphodiesterase type V inhibitor

19
Q

CIs of sildenafil?

A
  • Taking nitrates and related drugs e.g. nicorandil
  • Hypotension
  • Recent stroke or MI (wait 6 months)
20
Q

SE of sildenafil?

A
  • Visual disturbances (blue discolouration, non-arteritic anterior ischaemic neuropathy
  • Nasal congestion
  • Flushing
  • GI SE
  • Headaches

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