Drug Reactions

Question 1

what characterizes Stevens-Johnson Syndrome and TENS

Answer 1

invasion into the dermis with some necrosis of tissue

Question 2

When does a Type I hypersensitivity reaction occur?

Answer 2

Immediately - less than one hour of last administered dose

urticaria, anaphylaxis, edema

Question 3

how do you treat a suspected drug allergy

Answer 3

stop offending agent: don’t know which one, stop them ALL

antihistamines

+/- systemic steroids

Question 4

what is dermatographism?

Answer 4

scratching the surface of the skin, raised mark (a form of wheal) - sign of skin allergies

Question 5

what is the difference between SJS and TENS?

Answer 5

The body surface area involved

Question 6

What is the mortality for SJS? For TENS?

Answer 6

5-12% for SJS

>20% for TENS

Question 7

how long from drug exposure to the development of SJS?

Answer 7

within 8 weeks

Question 8

What is Niklosky’s sign?

Answer 8

skin has sloughs down all the way to dermis (superficial epithelium gone)

Question 9

What is a significant sequlae of SJS/TENS?

Answer 9

blindness from scarring of the cornea

Question 10

what should you NEVER use with a SJS/TENS patient?

Answer 10

chlorohexidine-impregnated patch